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Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.

Author: CrumrineDebra, EliasPeter M, FeingoldKenneth R, GschwandtnerMaria, HupeMelanie, LeeHae-Jin, LinTzu-Kai, ManMao-Qiang, OdaYuko, ParkKyungho, RoelandtTruus, SantiagoJuan-Luis, ThyssenJacob P, TrullasCarles, TschachlerErwin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study investigated the effects of topical histamine type 1 and 2 receptor (H1/2r) antagonists on inflammatory dermatoses in mice. The results showed that topical H1/2r antagonists enhanced permeability barrier homeostasis, reduced inflammation, and improved barrier function.
Paper Details　
Original Abstract of the Article :
Systemic antagonists of the histamine type 1 and 2 receptors (H1/2r) are widely used as anti-pruritics and central sedatives, but demonstrate only modest anti-inflammatory activity. Because many inflammatory dermatoses result from defects in cutaneous barrier function, and because keratinocytes expr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23014339

データ提供：米国国立医学図書館（NLM）

Topical Antihistamines: A New Approach for Inflammatory Dermatoses

Systemic antihistamines are commonly used for treating allergic reactions and inflammation, but their effectiveness in treating inflammatory dermatoses is limited. This study investigates the potential benefits of topical antihistamines for treating inflammatory dermatoses. It explores the anti-inflammatory activity of topical antihistamines, which targets the histamine type 1 and 2 receptors (H1/2r) in the skin.

Topical Antihistamines: Enhancing Skin Barrier Function

The study found that topical antihistamines not only provide anti-inflammatory benefits but also enhance skin barrier function, which is crucial for protecting the skin from external irritants and allergens. This suggests that topical antihistamines could offer a more effective approach for treating inflammatory dermatoses.

Skin Care: A Holistic Approach

This study underscores the importance of a holistic approach to skin care, emphasizing the need to address both inflammation and compromised barrier function. It suggests that topical antihistamines could provide a more effective and targeted approach to treating a variety of inflammatory dermatoses.

Dr. Camel's Conclusion

Just as a camel's thick coat protects it from the desert sun, this study reveals the importance of a healthy skin barrier in protecting against inflammation. It highlights the potential of topical antihistamines for effectively treating inflammatory dermatoses by both reducing inflammation and enhancing barrier function.

Date :
  1. Date Completed 2013-03-12
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23014339

DOI: Digital Object Identifier

NIHMS399937

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Languages

English

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