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Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients.

Author: LinJianxin, LoweRobert S, SchaeferErnst J, ShahArvind K, TershakovecAndrew M, ThongtangNuntakorn, TomassiniJoanne E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study examines whether adding ezetimibe to existing statin treatment is the most effective way to lower "bad" cholesterol (LDL-C) in people already taking high-dose statins. The study also investigates how these medications might affect cholesterol absorption and production.
Paper Details　
Original Abstract of the Article :
Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23040830

データ提供：米国国立医学図書館（NLM）

Decoding the Complex Dance of Cholesterol: Statins and Ezetimibe

In the realm of cardiovascular health, the quest for effective cholesterol management is an ongoing pursuit. Statins, powerful inhibitors of cholesterol synthesis, are often the first line of defense. But their effects can be complex, as they can also increase cholesterol absorption. This study delves into the intricate interplay between statins and ezetimibe, a drug that inhibits cholesterol absorption. The authors investigate the potential synergy between these two medications in lowering LDL-cholesterol (LDL-C), a critical factor in cardiovascular disease.

A Duet of Medications for Cholesterol Control

This research explores the combined effects of statins and ezetimibe in patients with hyperlipidemia. The authors focus on the impact of these medications on key markers of cholesterol absorption (β-sitosterol) and synthesis (lathosterol), providing valuable insights into their intricate interaction within the body. The study's findings will shed light on the effectiveness of this combined approach in lowering LDL-C, a crucial step in preventing cardiovascular complications.

Optimizing Cholesterol Management for a Healthier Heart

The results of this study have significant implications for patients with high cholesterol levels. By understanding the complex interplay between statins and ezetimibe, healthcare professionals can tailor treatment strategies to achieve optimal cholesterol control, reducing the risk of cardiovascular disease. This research reinforces the importance of personalized medicine, where treatment is tailored to the unique needs of each patient.

Dr.Camel's Conclusion

Just as a camel navigates the complex and diverse landscape of the desert, researchers are navigating the intricate world of cholesterol management. This research provides a deeper understanding of the synergistic effects of statins and ezetimibe, paving the way for more effective and personalized approaches to lowering LDL-C and promoting cardiovascular health.

Date :
  1. Date Completed 2013-05-02
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23040830

DOI: Digital Object Identifier

NIHMS493752

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Languages

English

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