Disparate effects of the prostaglandin synthesis inhibitors, meclofenamate, and flurbiprofen on monkey luteal tissue in vitro.

Author: MolsknessT A, SargentE L, StoufferR L, Zelinski-WootenM B

Paper Details 
Original Abstract of the Article :
Intraluteal infusion of the prostaglandin (PG) synthesis inhibitor, sodium meclofenamate (Mec) causes premature luteolysis in rhesus monkeys. To evaluate further the actions of PG synthesis inhibitors in primate luteal function, we examined the in vitro effects of Mec and another inhibitor, flurbipr...See full text at original site
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引用元:
https://doi.org/10.1210/endo-126-3-1380

データ提供:米国国立医学図書館(NLM)

Prostaglandin Synthesis Inhibitors: A Tale of Two Compounds

This research explores the effects of two prostaglandin (PG) synthesis inhibitors, meclofenamate (Mec) and flurbiprofen (Flur), on primate luteal tissue in vitro. The authors meticulously examined the impact of these inhibitors on PG synthesis, cAMP production, and progesterone (P) production by macaque luteal cells. Their findings reveal distinct mechanisms of action for these two inhibitors, highlighting the importance of understanding the specific effects of individual PG synthesis inhibitors on luteal function.

Navigating the Desert of Luteal Function

This research, like a caravan traversing the diverse landscape of luteal function, delves into the complex effects of prostaglandin synthesis inhibitors. The authors meticulously examine the impact of meclofenamate (Mec) and flurbiprofen (Flur) on primate luteal cells, revealing distinct mechanisms of action for these two inhibitors. The findings highlight the importance of understanding the specific effects of individual compounds within this class of drugs, particularly in the context of luteal function and reproductive health.

A New Horizon in Luteal Function Research

This study, like a desert explorer uncovering new frontiers in luteal function research, reveals the distinct mechanisms of action of two commonly used prostaglandin synthesis inhibitors. The findings underscore the importance of considering the specific effects of individual compounds within this class of drugs, particularly in the context of luteal function and reproductive health. This research encourages further exploration of these compounds, aiming to better understand their role in regulating luteal function and improving reproductive outcomes.

Dr.Camel's Conclusion

This research, like a journey through the desert of luteal function, reveals the distinct mechanisms of action of two prostaglandin synthesis inhibitors, meclofenamate and flurbiprofen. The findings underscore the importance of considering the specific effects of individual compounds within this class of drugs, particularly in the context of luteal function and reproductive health. This research encourages further exploration of these compounds, aiming to better understand their role in regulating luteal function and improving reproductive outcomes.

Date :
  1. Date Completed 1990-04-05
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

2307110

DOI: Digital Object Identifier

10.1210/endo-126-3-1380

Related Literature

SNS
PICO Info
in preparation
Languages

English

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