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Urodynamic effects of the combination of tamsulosin and daily tadalafil in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia: a randomized, placebo-controlled clinical trial.

Author: CerqueiraJoão Batista Gadelha, JamacaruFrancisco Vagnaldo F, JosinoIatagan Rocha, NogueiraEmmanuel Almeida, RegadasRommel Prata, RegesRicardo, SilvaLúcio Flávio Gonzaga, SucupiraDaniel Gabrielle, de MoraesManoel Odorico

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The association of tamsulosin/tadalafil reduces detrusor pressure at maximum flow without changing the maximum flow rate during micturition and significantly improves lower urinary tract symptoms compared with the isolated use of tamsulosin.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To evaluate the effect of association of tamsulosin/tadalafil taken daily compared with tamsulosin/placebo in the lower urinary tract with urodynamic study (UDS). METHODS: All patients underwent baseline UDS before randomization to tamsulosin 0.4 mg/tadalafil 5 mg (Group 1; n = 20) or t...See full text at original site
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引用元：
https://doi.org/10.1007/s11255-012-0317-7

データ提供：米国国立医学図書館（NLM）

Tamsulosin and Tadalafil: A Dynamic Duo for Lower Urinary Tract Symptoms

Lower urinary tract symptoms (LUTS) can be a common and often embarrassing issue, particularly in men. This study investigates the combined effect of tamsulosin and tadalafil, two medications commonly used to treat LUTS, on urodynamic parameters. Imagine a camel struggling to navigate a narrow desert passage, this combination of medications acts like a powerful team to clear the path! The researchers compared the effects of the combination treatment with tamsulosin alone in men with LUTS secondary to benign prostatic hyperplasia. They found that the combination treatment significantly reduced detrusor pressure at maximum flow, a key indicator of bladder function, without affecting the flow rate. Additionally, the combination treatment led to significant improvements in overall LUTS severity.

Tamsulosin and Tadalafil: A Synergistic Approach to LUTS Management

The study's findings demonstrate the potential benefits of combining tamsulosin and tadalafil for managing LUTS in men. This synergistic approach can lead to improved bladder function and a significant reduction in symptom severity.

Managing LUTS: A Comprehensive Approach for Improved Quality of Life

The study highlights the importance of a comprehensive approach to managing LUTS. By combining medications and addressing individual patient needs, we can effectively alleviate symptoms and improve quality of life. Just as a camel adapts its gait to navigate different desert terrains, men with LUTS can find relief and regain control over their bladder function through tailored treatment strategies.

Dr.Camel's Conclusion

The study demonstrates the effectiveness of combining tamsulosin and tadalafil for managing lower urinary tract symptoms. This synergistic approach can lead to improved bladder function and a significant reduction in symptom severity, offering a more comprehensive and effective solution for men with LUTS.

Date :
  1. Date Completed 2013-08-26
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23108604

DOI: Digital Object Identifier

10.1007/s11255-012-0317-7

Related Literature

Article Analysis
・Effects of tamsulosin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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