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Effects of dalcetrapib in patients with a recent acute coronary syndrome.

Author: , AbtMarkus, BallantyneChristie M, BarterPhilip J, BrummJochen, ChaitmanBernard R, HolmeIngar M, KallendDavid, LeiterLawrence A, LeitersdorfEran, McMurrayJohn J V, MundlHardi, NichollsStephen J, OlssonAnders G, SchwartzGregory G, ShahPrediman K, TardifJean-Claude, WrightR Scott

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Higher levels of high-density lipoprotein (HDL) cholesterol have been linked to a lower risk of coronary heart disease. However, whether raising HDL cholesterol levels through medication actually reduces cardiovascular risk is uncertain. Inhibition of cholesteryl ester transfer protein (CETP) increases HDL cholesterol levels, which may lead to improved cardiovascular outcomes.
Paper Details　
Original Abstract of the Article :
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl est...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa1206797

データ提供：米国国立医学図書館（NLM）

Dalcetrapib: A Quest for Heart Health in the Desert

High-density lipoprotein (HDL) cholesterol, often referred to as 'good' cholesterol, is associated with reduced risk of heart disease. This study delves into the potential of dalcetrapib, a drug that raises HDL cholesterol levels, to improve cardiovascular outcomes in patients who have experienced a recent acute coronary syndrome. The researchers aimed to investigate whether increasing HDL cholesterol levels therapeutically could translate to better outcomes for these patients.

The Promise of HDL Cholesterol

The study examined the effects of dalcetrapib on patients with a recent acute coronary syndrome. However, the results did not show a significant benefit for patients who received dalcetrapib compared to those who received a placebo. This is a reminder that the journey to improve heart health is complex and multifaceted. It's like searching for a hidden oasis in a vast desert – simply raising HDL cholesterol levels may not be enough to achieve the desired outcome.

The Need for Continued Research

This study underscores the need for continued research to understand the complex interplay between HDL cholesterol and cardiovascular health. It's like navigating a desert – finding the right path to achieve a desired outcome often requires a deeper understanding of the terrain. Further research is needed to explore the potential benefits of HDL-raising therapies and develop more effective strategies for preventing and managing heart disease.

Dr. Camel's Conclusion

The search for effective therapies to improve cardiovascular health is an ongoing journey, much like navigating a vast desert. This study explored the potential of dalcetrapib, a drug that raises HDL cholesterol levels, to reduce cardiovascular risk. While the results did not show a significant benefit, they emphasize the need for further exploration to understand the complex role of HDL cholesterol in heart health. This journey requires continued research and a multifaceted approach to find the right path to a healthier heart.

Date :
  1. Date Completed 2012-12-12
  2. Date Revised 2023-01-20
Further Info :

Pubmed ID

23126252

DOI: Digital Object Identifier

10.1056/NEJMoa1206797

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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