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Effect of dose on nicotine's reinforcing, withdrawal-suppression and self-reported effects.

Author: FenwickJ W, GustS W, HughesJ R, KeenanR M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Nicotine gum was more effective in helping people quit smoking in the long term when higher doses were used. However, higher doses were associated with more side effects in the first week.
Paper Details　
Original Abstract of the Article :
Seventy-eight smokers trying to quit were randomly assigned to 0-, 0.5-, 2- and 4-mg doses of nicotine gum and tracked for 9 months. In the 1st week of abstinence, self-administration of gum did not differ by dose (4 mg = 2 mg = 0.5 mg = 0 mg). Higher doses did not more effectively suppress withdraw...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2319467

データ提供：米国国立医学図書館（NLM）

Nicotine's Reinforcing and Withdrawal-Suppression Effects

Nicotine addiction, like a mirage in the desert, can be a challenging and persistent problem. This study explores the dose-response effects of nicotine gum on smokers trying to quit. The researchers randomly assigned participants to different doses of nicotine gum and tracked their progress over nine months.

The results revealed a fascinating pattern. While higher doses of nicotine gum didn't provide more effective withdrawal suppression or improve the accuracy of nicotine identification, they did appear to support more gum self-administration over time in those who managed to quit long-term. This suggests that nicotine's reinforcing effects may be dose-dependent, and higher doses might be needed for sustained abstinence, particularly in the long term.

Understanding Nicotine's Complex Role

This research sheds light on the complex relationship between nicotine dose and its reinforcing and withdrawal-suppression effects. It highlights the need for personalized approaches in nicotine replacement therapy.

Finding the Right Path to Quit

This study emphasizes the importance of tailoring nicotine replacement therapy to individual needs. The dose-response effects of nicotine gum suggest that finding the right dose can be crucial for achieving successful long-term abstinence.

Dr.Camel's Conclusion

As a camel who has encountered many a deceptive mirage in the desert, I understand the allure of nicotine. This study provides valuable insights into its complex effects, suggesting that navigating the path to quitting requires a careful understanding of its nuances and potential impact on different people.

Date :
  1. Date Completed 1990-05-03
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

2319467

DOI: Digital Object Identifier

2319467

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SNS
PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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