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A randomized, double-blind, controlled trial of the 17D yellow fever virus vaccine given in combination with immune globulin or placebo: comparative viremia and immunogenicity.

Author: , AhmedRafi, AkondyRama S, BarrettAlan, CetronMartin, EdupugantiSrilatha, EidexRachel B, KeyserlingHarry, LanciottiRobert, LipmanHarvey, MulliganMark J, OrensteinWalter, PanYi, QuerecTroy, TeuwenDirk, del RioCarlos

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effect of co-administering yellow fever vaccine with human immunoglobulin containing neutralizing antibodies. It found no difference in viremia, immunogenicity, or adverse events between the two groups.
Paper Details　
Original Abstract of the Article :
We evaluated whether coadministration of the yellow fever (YF) virus vaccine with human immunoglobulin (Ig) that contained YF virus-neutralizing antibodies would reduce post-vaccination viremia without compromising immunogenicity and thus, potentially mitigate YF vaccine-associated adverse events. W...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541731/

データ提供：米国国立医学図書館（NLM）

Yellow Fever Vaccine: Exploring the Role of Immunoglobulin in Mitigation

The [yellow fever vaccine] is a vital tool for protecting travelers from this potentially deadly disease. This study delves into the complex interplay between the vaccine and [human immunoglobulin (Ig)], investigating the potential impact of Ig on viremia and immunogenicity. Imagine a desert caravan preparing for a challenging journey, seeking to optimize their protection against potential threats.

A Quest for Enhanced Protection

The researchers hypothesized that co-administering the yellow fever vaccine with Ig containing anti-yellow fever virus antibodies could mitigate the risk of post-vaccination viremia without compromising immunogenicity. It's like a caravan leader seeking to reinforce their defenses against the dangers of the desert, ensuring a safe and successful journey. The results of the study, however, found no significant differences between the groups receiving Ig and those receiving a placebo. It's like discovering that a seemingly protective measure doesn't significantly impact the overall outcome.

Navigating Uncertainties in Vaccine Strategies

This research offers valuable insights into the complex relationship between the yellow fever vaccine and Ig. It's like a desert explorer encountering an unexpected twist in their journey, prompting a re-evaluation of existing strategies. The findings raise important questions about the role of Ig in yellow fever vaccination and provide a foundation for further research into potential mitigation strategies. It's a reminder that the journey to optimal vaccine effectiveness is an ongoing exploration, requiring ongoing research and careful consideration of all potential factors.

Dr.Camel's Conclusion

This study highlights the importance of rigorous research and careful analysis in the world of vaccine development and administration. It's a testament to the ongoing quest for safe and effective vaccines, ensuring the protection of travelers and safeguarding global health.

Date :
  1. Date Completed 2013-02-26
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23208880

DOI: Digital Object Identifier

PMC3541731

Related Literature

Article Analysis
・Side Effects of yellow fever vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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