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Heterosexual HIV-1 infectiousness and antiretroviral use: systematic review of prospective studies of discordant couples.

Author: BaggaleyRebecca F, BoilyMarie-Claude, HollingsworthT Déirdre, WhiteRichard G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

While studies have estimated how much HIV treatment reduces the risk of transmission, well-controlled trials with strict adherence guidance may overestimate the effectiveness of treatment-as-prevention in real-world settings.
Paper Details　
Original Abstract of the Article :
Recent studies have estimated the reduction in HIV-1 infectiousness with antiretroviral therapy (ART), but high-quality studies such as randomized controlled trials, accompanied by rigorous adherence counseling, are likely to overestimate the effectiveness of treatment-as-prevention in real-life set...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23222513

データ提供：米国国立医学図書館（NLM）

Heterosexual HIV-1 Infectiousness and Antiretroviral Use

The impact of antiretroviral therapy (ART) on HIV transmission is a critical area of research. This study examines the effectiveness of ART in reducing HIV-1 infectiousness in heterosexual couples where one partner is HIV-positive and the other is HIV-negative.

Antiretroviral Therapy's Impact on HIV Transmission

While ART has been shown to significantly reduce HIV transmission, the study highlights the need for further research on the effectiveness of ART-as-prevention strategies in real-life settings. This is because rigorous adherence counseling and strict adherence to treatment protocols in clinical trials might overestimate the effectiveness of ART in reducing HIV transmission.

HIV Prevention: A Collaborative Effort

HIV transmission is a complex issue that requires ongoing research and collaborative efforts to develop effective prevention strategies. This study underscores the importance of addressing factors such as adherence to ART and real-life settings in evaluating the effectiveness of HIV prevention strategies. It's important to remember that HIV is a serious health concern, and prevention is crucial in protecting individuals and communities.

Dr. Camel's Conclusion

This study, like a desert oasis, reminds us that while ART has proven effective in reducing HIV transmission, there's still a lot of ground to cover in developing effective prevention strategies. We need to be vigilant in addressing the complexities of HIV transmission, just as camels navigate the challenges of the desert. Only through continued research and collaboration can we find a way to effectively combat this global health issue.

Date :
  1. Date Completed 2013-05-30
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

23222513

DOI: Digital Object Identifier

EMS61817

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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