Efficacy and safety of pegylated interferon alfa-2a or alfa-2b plus ribavirin for the treatment of chronic hepatitis C in children and adolescents: a systematic review and meta-analysis.

Author: CooperCurtis L, DruytsEric, KantersSteve, MillsEdward J, ThorlundKristian, WuPing, YayaSanni

Paper Details 
Original Abstract of the Article :
BACKGROUND: A systematic review and meta-analysis were conducted to examine the efficacy and safety of pegylated interferon (peg-IFN) alfa-2a and peg-IFN alfa-2b plus ribavirin (RBV) in children and adolescents with chronic hepatitis C virus (HCV). METHODS: Medline, Embase, and Cochrane Central Reg...See full text at original site
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引用元:
https://doi.org/10.1093/cid/cis1031

データ提供:米国国立医学図書館(NLM)

Treating Hepatitis C in Children and Adolescents: A New Oasis of Hope

The vast landscape of pediatric hepatitis C research is constantly evolving, with scientists seeking safe and effective treatments for children and adolescents infected with this virus. This study explores the efficacy and safety of pegylated interferon (peg-IFN) alfa-2a or alfa-2b combined with ribavirin (RBV) in treating chronic hepatitis C in younger patients. The researchers conducted a systematic review and meta-analysis of clinical trials, compiling data from multiple studies to provide a comprehensive assessment of this treatment approach.

A Promising Treatment Option for Younger Patients

The meta-analysis found that the combination treatment of peg-IFN/RBV was effective and generally safe in treating children and adolescents with hepatitis C. The treatment achieved a significant sustained virologic response (SVR), meaning the virus was undetectable after treatment completion, in a majority of patients. The researchers also noted that the treatment was well-tolerated, with manageable side effects. This finding suggests that peg-IFN/RBV combination therapy could be a valuable option for younger patients battling chronic hepatitis C.

A Brighter Future for Children with Hepatitis C

This research offers hope for children and adolescents living with hepatitis C, providing a potential pathway to a healthier and more fulfilling life. The study's findings suggest that peg-IFN/RBV combination treatment can effectively control the virus and potentially lead to long-term remission. This research underscores the importance of ongoing research and development in pediatric hepatitis C, aiming to provide effective and safe treatment options for all those affected by this challenging condition. This research reminds us that even in the challenging desert of chronic illness, we can find oases of hope and progress, paving the way for a brighter future for children and adolescents.

Dr. Camel's Conclusion

This research provides valuable insights into the treatment of chronic hepatitis C in children and adolescents, offering a glimmer of hope for those navigating this challenging terrain. The findings demonstrate the effectiveness and safety of peg-IFN/RBV combination therapy in younger patients, suggesting a potential pathway to a healthier and more fulfilling life. This research encourages us to continue exploring and developing new treatments for pediatric hepatitis C, striving to create a world where all children and adolescents have access to safe and effective care.

Date :
  1. Date Completed 2013-08-26
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

23243171

DOI: Digital Object Identifier

10.1093/cid/cis1031

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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