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[Tacrine and its derivatives in the therapy of Alzheimers disease].

Author: BenekOndřej, KorábečnýJan, KučaKamil, MusílekKamil, SoukupOndřej, SpilovskáKatarína

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cholinesterase inhibitors are the main drugs used to treat Alzheimer's disease. Tacrine, the first cholinesterase inhibitor approved for treatment, had significant side effects. This review summarizes research on newer tacrine analogues, which aim to provide similar benefits with fewer side effects.
Paper Details　
Original Abstract of the Article :
Cholinesterase inhibitors have beneficial effects on the cognitive, functional, and behavioural symptoms of Alzheimers disease (AD). Up to date, they represent almost the only drugs approved by the U.S. Food and Drug Administration agency for AD treatment. The group involves donepezil, rivastigmine ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/23256654

データ提供：米国国立医学図書館（NLM）

Tacrine and Its Derivatives: A Journey Through Alzheimer's Therapy

Alzheimer's disease, a devastating neurodegenerative disorder, presents a formidable challenge for researchers seeking effective treatments. This study explores the potential of tacrine and its derivatives as therapeutic agents for Alzheimer's disease.

Tacrine's Legacy: A Path Towards New Therapies

This study delves into the history and evolution of tacrine, a pioneering cholinesterase inhibitor used in Alzheimer's treatment. While tacrine's use has been limited due to side effects, the study highlights the ongoing efforts to develop novel tacrine analogues with improved efficacy and safety profiles. These efforts offer hope for developing new drugs that can effectively combat Alzheimer's disease and improve the lives of patients.

Alzheimer's Disease: A Long and Winding Road

Alzheimer's disease is a complex and challenging condition that requires a multi-pronged approach to treatment and management. This study's exploration of tacrine and its derivatives underscores the ongoing research efforts to develop new therapies that can effectively address the cognitive decline and other symptoms associated with this devastating disease. Remember, early detection and timely intervention are crucial for managing Alzheimer's disease and maximizing treatment success.

Dr.Camel's Conclusion

This study, like a camel trekking across a vast desert of scientific knowledge, provides a valuable glimpse into the ongoing journey to develop effective treatments for Alzheimer's disease. The research highlights the potential of tacrine and its derivatives, offering hope for new therapies that can combat this debilitating condition and improve the quality of life for patients.
Date :
  1. Date Completed 2013-03-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23256654

DOI: Digital Object Identifier

39300

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Article Analysis
・Side Effects of rivastigmine
SNS
PICO Info
in preparation
Languages

Czech

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