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Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode.

Author: AmmermanDiane, BakerRoss A, CarlsonBerit X, FountoulakisKonstantinos N, FyansPaula, MarlerSabrina V, RahmanZia, YathamLakshmi N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

People with bipolar disorder who experience manic or mixed episodes (both mania and depression) may respond differently to treatment. This study looks at how effective the medication aripiprazole is in preventing relapses in people with bipolar disorder who had either manic or mixed episodes, when combined with either lithium or valproate.
Paper Details　
Original Abstract of the Article :
Differences in response to treatment have been observed for bipolar disorder (BPD) patients with manic or mixed episodes. This post-hoc analysis examined the maintenance effect of aripiprazole in combination with lithium or valproate in subpopulations of patients entering a relapse prevention study ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2012.11.042

データ提供：米国国立医学図書館（NLM）

Tailoring Treatment for Bipolar Disorder: Aripiprazole's Role

This study ventures into the complex world of

psychiatry

, specifically focusing on the treatment of bipolar disorder (BPD). The researchers, like detectives piecing together clues in a vast desert of mental health, examined the effectiveness of aripiprazole in combination with lithium or valproate for relapse prevention in patients with BPD. The study focused on two distinct subpopulations: those with manic episodes and those with mixed episodes. The researchers found that aripiprazole was effective in preventing relapse in both subgroups, suggesting a potential benefit across different presentations of BPD.

Aripiprazole: A Powerful Tool for Relapse Prevention

This study highlights the effectiveness of aripiprazole in preventing relapse in patients with bipolar disorder, demonstrating its potential as a valuable tool for managing this complex condition. The research, like a compass guiding a traveler through the desert, shows that aripiprazole may be a useful tool for navigating the challenges of BPD and improving long-term outcomes.

Understanding the Unique Needs of Bipolar Patients

This study emphasizes the importance of understanding the diverse presentations of bipolar disorder and tailoring treatment strategies accordingly. The researchers found that aripiprazole was effective in both manic and mixed episodes, suggesting that it may be a valuable treatment option for a wider range of BPD patients. This research highlights the need for individualized treatment approaches to meet the unique needs of those struggling with bipolar disorder.

Dr.Camel's Conclusion

This research provides valuable insights into the effectiveness of aripiprazole in preventing relapse in patients with bipolar disorder, highlighting its potential as a valuable treatment option for managing this challenging condition. The study underscores the importance of individualized treatment approaches to meet the unique needs of those with bipolar disorder, ensuring they receive the most appropriate care for their specific needs.

Date :
  1. Date Completed 2013-12-30
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23290791

DOI: Digital Object Identifier

10.1016/j.jad.2012.11.042

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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