Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine.

Author: BarrAlasdair M, BoydaHeidi N, HawkesErin, HonerWilliam G, JinChen Helen, PangCatherine C Y, ProcyshynRic M, WongDaniel

Paper Details 
Original Abstract of the Article :
The second generation antipsychotic (SGA) drugs are widely used in psychiatry due to their clinical efficacy and low incidence of neurological side-effects. However, many drugs in this class cause deleterious metabolic side-effects. Animal models accurately predict metabolic side-effects for SGAs wi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541274/

データ提供:米国国立医学図書館(NLM)

Second-Generation Antipsychotics: A Camel's Journey Through the Desert of Metabolic Side-Effects

The field of mental health is a vast and challenging desert, with many hurdles to overcome. This study explores the metabolic side effects of second-generation antipsychotic drugs, a class of medications widely used to treat psychiatric disorders. The researchers compare the effects of asenapine and iloperidone to olanzapine, a well-established antipsychotic, using preclinical models to assess glucose intolerance and insulin resistance. These findings are crucial, as they provide insights into the potential metabolic risks associated with these medications, information that can guide future clinical practice and improve patient outcomes.

Second-Generation Antipsychotics: A Balancing Act in the Desert

The study found that asenapine and iloperidone, like two camels traversing the desert, each had their own unique metabolic profiles. While these drugs are generally well-tolerated, they can pose metabolic risks, particularly for individuals with pre-existing metabolic conditions. The study highlights the importance of carefully monitoring patients for these potential side effects and adjusting treatment strategies accordingly. It's a reminder that balancing the benefits and risks of medication is a crucial aspect of medical practice.

Second-Generation Antipsychotics: A Desert of Opportunities and Challenges

This research underscores the importance of carefully considering the metabolic risks associated with second-generation antipsychotics, particularly for individuals with pre-existing metabolic conditions. It's like navigating a desert landscape, where the path can be unpredictable and potential pitfalls must be avoided. By carefully monitoring patients and adjusting treatment strategies as needed, we can help ensure their safety and optimal well-being.

Dr.Camel's Conclusion

This research highlights the importance of considering the potential metabolic side effects of second-generation antipsychotics. It's a reminder that the use of any medication involves a delicate balance of benefits and risks. As we continue to explore the complexities of mental health, we must strive to develop medications that are both effective and safe, ensuring that patients receive the best possible care.

Date :
  1. Date Completed 2013-07-02
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

23326434

DOI: Digital Object Identifier

PMC3541274

Related Literature

SNS
PICO Info
in preparation
Languages

English

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