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Influence of cimetidine and its metabolites on Cisplatin--investigation of adduct formation by means of electrochemistry/liquid chromatography/electrospray mass spectrometry.

Author: BrauckmannChristine, FaberHelene, KarstUwe, Lanvers-KaminskyClaudia, SperlingMichael

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cimetidine may reduce the side effects of Cisplatin in cancer chemotherapy. This study investigated the interaction between Cisplatin and cimetidine at the molecular level. Cisplatin-cimetidine adducts were detected. However, no significant interactions were observed between Cisplatin and cimetidine metabolites. In the presence of cimetidine, Cisplatin's affinity for the model protein β-lactoglobulin A appears to be increased.
Paper Details　
Original Abstract of the Article :
Cimetidine has been studied as an additive in cancer chemotherapy. It is claimed to reduce the side effects of Cisplatin. This study focuses on possible interactions between Cisplatin and cimetidine on the molecular level. Due to the fact that cimetidine is metabolized in the liver, interactions bet...See full text at original site
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引用元：
https://doi.org/10.1016/j.chroma.2012.12.069

データ提供：米国国立医学図書館（NLM）

Cimetidine and Cisplatin: Investigating Potential Interactions

The field of oncology is constantly striving to optimize cancer treatment strategies, including the use of chemotherapy agents. This study investigates the potential interactions between cimetidine, a histamine H2 receptor antagonist, and cisplatin, a widely used chemotherapy drug. The authors employed a combination of electrochemical and liquid chromatography/electrospray mass spectrometry techniques to examine the molecular interactions between these medications. This study provides valuable insights into the potential for drug interactions between cimetidine and cisplatin, highlighting the importance of considering these factors in cancer treatment.

Potential for Drug Interactions Between Cimetidine and Cisplatin

This study suggests that cimetidine may interact with cisplatin at the molecular level, potentially influencing its efficacy and toxicity. The authors observed the formation of adducts between cimetidine and cisplatin, indicating a potential for these medications to interact within the body. The study highlights the importance of careful consideration of potential drug interactions when prescribing cimetidine and cisplatin concurrently.

Optimizing Cancer Treatment Strategies Through Understanding Drug Interactions

This research underscores the importance of understanding drug interactions in cancer treatment. The authors' findings suggest that cimetidine may influence the activity of cisplatin, highlighting the need for careful consideration of these factors in treatment planning. This study emphasizes the importance of ongoing research to identify potential drug interactions and optimize cancer treatment strategies.

Dr. Camel's Conclusion

This study on cimetidine and cisplatin is like a desert sandstorm, revealing the hidden dangers of potential drug interactions. The researchers employed advanced techniques to examine the molecular interactions between these medications, uncovering the potential for unexpected consequences. This study, like a beacon warning of hidden hazards, reminds us of the importance of careful consideration of drug interactions in cancer treatment.

Date :
  1. Date Completed 2013-07-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23352827

DOI: Digital Object Identifier

10.1016/j.chroma.2012.12.069

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Languages

English

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