17DD yellow fever vaccine: a double blind, randomized clinical trial of immunogenicity and safety on a dose-response study.

Author: AlmeidaLuiz Fernando C, CamachoLuiz Antonio B, FariasRoberto Henrique G, FreireMarcos S, FreireRicardo Aguiar V, GallerRicardo, HokamaDarcy A, HommaAkira, LealMaria da Luz Fernandes, LimaSheila Maria B, MaiaMaria de Lourdes S, MartinsReinaldo M, NogueiraRita Maria R, Pereira FilhoEdson, SáGloria Regina S, YamamuraAnna Maya Yoshida, de CarvalhoRicardo

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To verify if the Bio-Manguinhos 17DD yellow fever vaccine (17DD-YFV) used in lower doses is as immunogenic and safe as the current formulation. RESULTS: Doses from 27,476 IU to 587 IU induced similar seroconversion rates and neutralizing antibodies geometric mean titers (GMTs). Immunity ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903908/

データ提供:米国国立医学図書館(NLM)

17DD Yellow Fever Vaccine: A Dose of Confidence for Travelers

Yellow fever, a serious viral disease, can be prevented through vaccination. This study investigates the efficacy and safety of the 17DD yellow fever vaccine at various doses. Think of it like a camel preparing for a long desert journey, seeking the optimal amount of water and provisions for the trip. The researchers found that doses ranging from 27,476 IU to 31 IU induced similar seroconversion rates and neutralizing antibody levels, suggesting that lower doses of the vaccine are just as effective as the standard dose. This finding could have significant implications for vaccine accessibility and affordability.

A New Frontier in Vaccination: Optimizing Dose and Efficacy

This study highlights the potential for using lower doses of the 17DD yellow fever vaccine without compromising efficacy. Think of it like a camel adjusting its pace in the desert, conserving energy while still reaching its destination. The researchers found that even very low doses of the vaccine were effective in inducing immunity against yellow fever. This finding could help to expand vaccine access to more individuals, particularly in resource-limited settings.

Safe and Effective: A Desert Oasis of Protection

This study provides reassuring evidence about the safety and efficacy of the 17DD yellow fever vaccine. It's like a desert oasis offering travelers a safe haven from the harsh elements. The researchers found that the vaccine was well-tolerated at all doses, with minimal reactogenicity. This underscores the importance of continued research to optimize vaccine strategies and ensure widespread protection against yellow fever.

Dr.Camel's Conclusion

This research provides valuable insights into the safety and efficacy of the 17DD yellow fever vaccine, reminding us that even in the face of a global health challenge, we can find innovative solutions that improve our well-being and ensure a safer world.

Date :
  1. Date Completed 2014-04-21
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

23364472

DOI: Digital Object Identifier

PMC3903908

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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