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Cathodal iontophoresis of treprostinil induces a sustained increase in cutaneous blood flux in healthy volunteers.

Author: BlaiseSophie, CracowskiJean-Luc, HellmannMarcin, MilletClaire, RoustitMatthieu

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prostacyclin analogues are effective for treating scleroderma digital ulcers, but their side effects limit their use. This study explored whether applying these drugs to the skin using iontophoresis, a method of delivering drugs using electric currents, could achieve sustained vasodilation, a widening of blood vessels, without causing significant side effects.
Paper Details　
Original Abstract of the Article :
Prostacyclin analogues are the most effective drugs to treat sclerodermic digital ulcers, but their systemic use is limited by their frequent side effects. The authors tested whether the prostacyclin analogues treprostinil and iloprost, delivered by cutaneous iontophoresis, induce sustained vasodila...See full text at original site
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引用元：
https://doi.org/10.1177/0091270011434352

データ提供：米国国立医学図書館（NLM）

Cathodal Iontophoresis of Treprostinil: A Novel Approach to Vasodilation

The [treatment of sclerodermic digital ulcers] is a challenging area in [rheumatology]. [Prostacyclin analogues], such as [treprostinil] and [iloprost], are effective but their [systemic administration] is often limited by [side effects]. This study investigates the potential of [cutaneous iontophoresis] to deliver [treprostinil] and [iloprost] directly to the skin, aiming to induce [sustained vasodilation].

Iontophoresis: A Targeted Delivery System

The researchers found that [cathodal iontophoresis] of [treprostinil] effectively induced [sustained increases in cutaneous blood flux] in healthy volunteers. These findings suggest that [iontophoresis] could be a valuable tool for delivering [prostacyclin analogues] locally, potentially reducing systemic side effects and improving treatment outcomes.

A New Horizon for Scleroderma Treatment

This study offers a glimmer of hope for individuals with [scleroderma]. By exploring novel delivery methods like [iontophoresis], we may be able to harness the power of [prostacyclin analogues] while minimizing [side effects]. It's like discovering a hidden oasis in the desert of scleroderma – a potential source of relief and improved treatment.

Dr. Camel's Conclusion

Cathodal iontophoresis of treprostinil effectively induces sustained vasodilation in the skin, offering a potential new approach for treating sclerodermic digital ulcers. This innovative delivery method could improve treatment outcomes while minimizing systemic side effects. It's like discovering a hidden oasis in the desert of scleroderma – a potential source of relief and improved treatment for individuals with this challenging condition.

Date :
  1. Date Completed 2013-07-30
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

23400744

DOI: Digital Object Identifier

10.1177/0091270011434352

Related Literature

Article Analysis
・Side Effects of iloprost
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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