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Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients.

Author: BoussemartL, FavreM, Kamsu-KomN, LacroixL, MateusC, OpletalovaK, RobertC, RoutierE, SebilleG, ThomasM, TomasicG, VagnerS, WechslerJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vemurafenib, a BRAF inhibitor used to treat metastatic melanoma, is associated with numerous adverse skin reactions, including verrucous papillomas, hand-foot skin reaction, and keratoacanthomas. Management of these side effects relies on symptomatic measures and sun photoprotection.
Paper Details　
Original Abstract of the Article :
BACKGROUND: BRAF inhibitors are being developed for the treatment of metastatic melanoma harboring a V600E mutation. The use of vemurafenib significantly increases progression-free survival (PFS) and overall survival (OS) in this population of patients, but is associated with numerous adverse skin r...See full text at original site
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引用元：
https://doi.org/10.1093/annonc/mdt015

データ提供：米国国立医学図書館（NLM）

Vemurafenib and Cutaneous Side Effects: A Dermatologic Study

This study explores the landscape of oncology and its impact on patients' skin health. The researchers are investigating the cutaneous side effects of vemurafenib, a BRAF inhibitor used to treat metastatic melanoma. They conducted a systematic dermatologic study, observing 42 patients undergoing vemurafenib treatment to document the various skin reactions associated with this medication.

Navigating the Side Effects of Vemurafenib

The study revealed that vemurafenib is associated with a range of cutaneous side effects, including verrucous papillomas, hand-foot skin reaction, and hyperkeratotic perifollicular rash. Furthermore, the researchers observed a significant incidence of keratoacanthomas and squamous cell carcinoma, highlighting the potential for skin malignancy with vemurafenib treatment.

Dr. Camel's Conclusion

This study emphasizes the importance of vigilant dermatologic monitoring in patients undergoing vemurafenib treatment. It highlights the potential for serious skin complications, emphasizing the need for early detection and management of these side effects.
Date :
  1. Date Completed 2013-11-18
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

23406731

DOI: Digital Object Identifier

10.1093/annonc/mdt015

Related Literature

Article Analysis
・Effects of vemurafenib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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