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Eradication of hepatitis C virus infection and the development of hepatocellular carcinoma: a meta-analysis of observational studies.

Author: BaackBrittney, Falck-YtterYngve, MorganRebecca L, PitasiMarc, SmithBryce D, YartelAnthony

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The systematic review assessed the association between sustained virologic response (SVR) to hepatitis C virus (HCV) therapy and hepatocellular carcinoma (HCC) development. SVR was associated with a reduced risk of HCC among HCV-infected persons at any stage of fibrosis and those with advanced liver disease.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma (HCC). In the United States, this form of cancer occurs in approximately 15 000 persons annually. A systematic review of the evidence is needed to assess the benefits of treatment of HCV-infected persons on developmen...See full text at original site
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引用元：
https://doi.org/10.7326/0003-4819-158-5-201303050-00005

データ提供：米国国立医学図書館（NLM）

Hepatitis C Virus Eradication and Hepatocellular Carcinoma Risk

This meta-analysis examines the association between [hepatitis C virus (HCV) eradication] and the development of [hepatocellular carcinoma (HCC)] in infected individuals. The authors analyzed data from multiple observational studies, finding a strong association between achieving [sustained virologic response (SVR)] after HCV treatment and a reduced risk of HCC development. This study reinforces the importance of HCV treatment in preventing HCC, particularly in individuals with advanced liver disease.

Preventing Liver Cancer: The Power of HCV Treatment

This research highlights the critical role of [HCV treatment] in preventing [liver cancer] (HCC). It's like building a protective barrier against a desert sandstorm, safeguarding the liver from the destructive forces of HCV infection. The findings strongly suggest that achieving SVR through treatment can significantly reduce the risk of developing HCC, emphasizing the importance of early diagnosis and intervention for HCV-infected individuals.

Navigating the Desert of Liver Disease: HCV Treatment and HCC Prevention

Imagine the liver as a delicate oasis, vulnerable to the harsh environment of HCV infection. This research emphasizes the importance of effective treatment to protect this oasis from the threat of HCC. The findings underscore the power of HCV treatment in preventing liver cancer, highlighting the critical role of medical intervention in safeguarding liver health.

Dr. Camel's Conclusion

This meta-analysis reveals a strong association between HCV eradication and a reduced risk of HCC development. It's like discovering a hidden well of protection in the desert of liver disease, offering a powerful weapon against the threat of liver cancer.
Date :
  1. Date Completed 2013-05-06
  2. Date Revised 2022-12-22
Further Info :

Pubmed ID

23460056

DOI: Digital Object Identifier

10.7326/0003-4819-158-5-201303050-00005

Related Literature

Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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