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Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS).

Author: BrownB Greg, KraussRonald M, MarcovinaSantica M, WilliamsPaul T, ZhaoXue-Qiao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigated the association between LDL-subclass cholesterol concentrations and coronary artery stenosis and cardiovascular events in patients with coronary artery disease. Higher concentrations of small LDL subfractions (LDL-IIIb and LDL-IVa) were associated with increased coronary artery stenosis and a greater odds for cardiovascular events.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Test whether angiographically-documented changes in percent stenosis and clinical endpoints (coronary-related deaths, myocardial infarctions, stroke, revascularization for worsening ischemia) in the HDL-Atherosclerosis Treatment Study (HATS) were attributable to specific LDL-subclasses. ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584097/

データ提供：米国国立医学図書館（NLM）

Navigating the Labyrinth of LDL Subclasses: Understanding Atherosclerosis Progression

Atherosclerosis, a major contributor to cardiovascular disease, is like a labyrinth of complex pathways that lead to heart problems. This study explores the role of different LDL subclasses in atherosclerosis progression and the risk of coronary heart disease (CHD). It is like deciphering the intricate map of a desert labyrinth, searching for clues to guide us through its twists and turns.

The Hidden Dangers of Small LDL Particles

The study reveals that higher concentrations of small LDL subfractions, specifically LDL-IIIb and LDL-IVa, are associated with increased atherosclerosis progression and an elevated risk of CHD events. This is like discovering a hidden trap in the desert labyrinth, a potential danger that needs to be avoided to reach the heart of the problem.

Finding the Right Path: Targeting Small LDL Particles

This study highlights the importance of focusing on specific LDL subclasses in managing atherosclerosis risk. This is like finding a safer path through the labyrinth, avoiding the traps and obstacles that can lead to heart disease. The study also emphasizes the role of therapeutic interventions, like simvastatin and niacin, in modifying LDL subclasses and reducing CHD risk.

Dr. Camel's Conclusion

This study sheds light on the critical role of specific LDL subclasses in atherosclerosis progression and CHD risk. It is like finding a new key to unlocking the secrets of the desert labyrinth, providing a more targeted approach to managing cardiovascular health. This research underscores the importance of understanding the intricate mechanisms of atherosclerosis and developing strategies to minimize its impact.
Date :
  1. Date Completed 2013-09-03
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

23460815

DOI: Digital Object Identifier

PMC3584097

Related Literature

Article Analysis
・Effective treatment of atherosclerosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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