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A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch.
Author: ChanYiong-Huak, HahnGary S, NattkemperLeigh A, PapoiuAlexandru D P, Valdes-RodriguezRodrigo, YosipovitchGil
Original Abstract of the Article :
The aim of this double-blinded, vehicle-controlled study was to test the antipruritic efficacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered...See full text at original site
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引用元:
https://doi.org/10.2340/00015555-1564
データ提供:米国国立医学図書館(NLM)
Strontium: A New Hope for Itch Relief?
Chronic itch can be a debilitating condition that significantly impacts quality of life. The field of dermatology is always searching for new and effective therapies to alleviate itch. This research explores the potential of topical strontium, a mineral commonly found in seawater, as a novel antipruritic agent. It focuses on its efficacy in relieving cowhage-induced itch, a non-histaminergic form of itch relevant to conditions like atopic dermatitis.
Strontium vs. Itch: A Head-to-Head Showdown
The researchers conducted a double-blinded, vehicle-controlled study comparing a topical strontium hydrogel formulation to two common antipruritic agents: hydrocortisone and diphenhydramine. They found that strontium significantly reduced the intensity and duration of cowhage-induced itch compared to the control group and was superior to the other two antipruritic agents. This finding suggests that strontium may hold promise as a treatment for chronic pruritus, particularly those not mediated by histamine.
A New Approach to Itch Relief
This research offers a potential breakthrough in the treatment of itch. Strontium has shown efficacy against both histamine-mediated and non-histaminergic forms of itch. Its potential benefits could extend to a wide range of chronic pruritic conditions. While further research is needed, this study paves the way for a novel, effective, and potentially safer approach to itch management.
Health Implications and Daily Life
For individuals suffering from chronic itch, this research offers a glimmer of hope. A topical strontium formulation could offer a new alternative to existing treatments, potentially providing relief from debilitating itch. However, it is essential to consult with a healthcare professional before using any new treatment, as strontium might interact with other medications or have unintended side effects.
Dr. Camel's Conclusion
Imagine the feeling of itch as a persistent desert wind, constantly irritating your skin. While some traditional anti-itch remedies are like a fleeting oasis, strontium might offer a more permanent solution, a sturdy sand dune shielding you from the wind’s relentless sting.
Date :
- Date Completed 2014-03-31
- Date Revised 2013-09-04
Further Info :
Related Literature
English
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