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Delayed versus immediate treatment for patients with acute hepatitis C: a randomised controlled non-inferiority trial.

Author: , BergThomas, BuggischPeter, CornbergMarkus, DeterdingKatja, DiepolderHelmut, FeyerabendSandra, GallePeter R, GroßhennigAnika, GrünerNorbert, HinrichsenHolger, JungMaria Christina, KochArmin, LüthStefan, MalekNisar, MannsMichael P, PotthoffAndrej, Rogalska-TarantaMagdalena, SchlaphoffVerena, SpenglerUlrich, WedemeyerHeiner, WiegandJohannes

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Early treatment for acute hepatitis C with interferon alfa has a high cure rate. However, the virus clears on its own in a significant number of people. This study compares two treatment approaches: starting treatment immediately versus waiting to see if the virus clears naturally.
Paper Details　
Original Abstract of the Article :
Early treatment of acute hepatitis C virus (HCV) infection with interferon alfa monotherapy is very effective, with cure rates of greater than 85%. However, spontaneous clearance of HCV occurs in 10-50% of cases. We aimed to assess an alternative treatment strategy of delayed antiviral therapy in pa...See full text at original site
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引用元：
https://doi.org/10.1016/S1473-3099(13)70059-8

データ提供：米国国立医学図書館（NLM）

Treating Hepatitis C: To Wait or Not to Wait?

The field of [Hepatitis C treatment] is continually evolving. This study delves into the intriguing question of [whether immediate treatment is better than delayed treatment for acute hepatitis C]. The researchers employed a [randomized controlled non-inferiority trial] to compare the two strategies. They found that [delayed treatment] may be a viable alternative to [immediate treatment] for patients who don't spontaneously clear the virus.

Delayed Treatment for Hepatitis C: A New Frontier?

This research suggests that [delaying treatment] may be a viable option for [some patients with acute hepatitis C]. This could potentially lead to [improved patient outcomes and reduced treatment burden].

Hepatitis C Treatment: Considering the Options

This study underscores the importance of [individualized treatment] for [patients with hepatitis C]. Understanding the [potential benefits and risks] of both [immediate and delayed treatment] is crucial for making informed decisions about treatment strategies.

Dr.Camel's Conclusion

The results of this study are like a desert oasis - a refreshing change in the landscape of [Hepatitis C treatment]. While [delayed treatment] may be a promising approach, more research is needed to ensure its safety and effectiveness for a wider range of patients.

Date :
  1. Date Completed 2013-11-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23523674

DOI: Digital Object Identifier

10.1016/S1473-3099(13)70059-8

Related Literature

Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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