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Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal.

Author: BrownVictoria L, CinciripiniPaul M, EngelmannJeffrey M, Karam-HageMaher, LamCho, MinnixJennifer A, RobinsonJason D, VersaceFrancesco, WetterDavid W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study compared the efficacy of varenicline, bupropion, and placebo for smoking cessation. Both varenicline and bupropion were significantly more effective than placebo at the end of treatment and 3-month follow-up. Varenicline was more effective at 6-month follow-up. Varenicline was associated with a decrease in depression symptoms.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: Given the actions of varenicline tartrate and bupropion hydrochloride sustained-release (SR) on neurobiological targets related to affect and reward, it is thought that the modulation of nicotine withdrawal symptoms may contribute to their effectiveness. OBJECTIVE: To assess the relativ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23536105

データ提供：米国国立医学図書館（NLM）

Varenicline and Bupropion: A head-to-head comparison for smoking cessation

Ah, the quest to quit smoking - a journey fraught with challenges and temptations. It's like navigating a treacherous sandstorm - a constant battle against the urge to light up. This study examines the effectiveness of two medications, varenicline and bupropion, in aiding smokers to break free from their nicotine addiction. The researchers sought to find the best tools to navigate this sandstorm, leading smokers towards a smoke-free oasis. They compared the effectiveness of these medications in helping smokers achieve long-term abstinence and their impact on emotional well-being.

Varenicline emerges as a champion

The study revealed that both varenicline and bupropion, when combined with intensive counseling, were significantly more effective than placebo in promoting prolonged abstinence from smoking. It's like finding a hidden oasis with two different paths - both lead to the same destination, a life free from the shackles of nicotine. However, varenicline proved to be more effective in the long run, with its effects on abstinence persisting for six months after the treatment ended. This is like discovering a path that not only leads to the oasis but also provides a stable route to stay there. Varenicline also demonstrated a remarkable ability to suppress depression and reduce smoking reward, suggesting that it might be particularly beneficial for those struggling with emotional and psychological dependence on nicotine.

A brighter future for smokers

This study provides valuable insights for smokers seeking to quit. Both varenicline and bupropion, combined with counseling, can significantly increase the chances of success. However, if you are struggling with depression or emotional dependence on nicotine, varenicline might be a better option for you. It's like choosing the right camel to navigate the treacherous desert - some are better suited for the journey than others. This research offers a ray of hope for those seeking to break free from the grip of nicotine addiction, providing a pathway to a healthier and more fulfilling life.

Dr.Camel's Conclusion

This study provides valuable insights for smokers seeking to quit. Both varenicline and bupropion, combined with counseling, can significantly increase the chances of success. However, if you are struggling with depression or emotional dependence on nicotine, varenicline might be a better option for you. It's like choosing the right camel to navigate the treacherous desert - some are better suited for the journey than others. This research offers a ray of hope for those seeking to break free from the grip of nicotine addiction, providing a pathway to a healthier and more fulfilling life.
Date :
  1. Date Completed 2013-06-27
  2. Date Revised 2022-04-19
Further Info :

Pubmed ID

23536105

DOI: Digital Object Identifier

NIHMS581695

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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