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New pharmacological approaches to the cholinergic system: an overview on muscarinic receptor ligands and cholinesterase inhibitors.

Author: GreigNigel H, RealeMarcella, TataAda M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the cholinergic system and its modulation by pharmacological drugs. It focuses on recent developments in muscarinic receptor ligands and cholinesterase inhibitors, highlighting their potential in treating nervous system diseases, including Alzheimer's disease, Sjogren's syndrome, and cancer.
Paper Details　
Original Abstract of the Article :
The cholinergic system is expressed in neuronal and in non-neuronal tissues. Acetylcholine (ACh), synthesized in and out of the nervous system can locally contribute to modulation of various cell functions (e.g. survival, proliferation). Considering that the cholinergic system and its functions are ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23597304

データ提供：米国国立医学図書館（NLM）

The Cholinergic System: A Journey Through the Nervous System

The intricate world of the nervous system is a fascinating and complex one, with countless pathways and interconnected systems working together to regulate our thoughts, actions, and bodily functions. This study explores the cholinergic system, a vital component of the nervous system that relies on the neurotransmitter acetylcholine. The authors examine recent advancements in understanding the cholinergic system and its role in various physiological processes and diseases, including Alzheimer's disease and cancer.

New Pharmacological Approaches to the Cholinergic System

The study explores the potential of new pharmacological approaches to modulate the cholinergic system, focusing on muscarinic receptor ligands and cholinesterase inhibitors. These drugs can either stimulate or block the activity of muscarinic receptors or inhibit the breakdown of acetylcholine, potentially impacting a wide range of functions within the nervous system. The researchers also discuss the potential implications of muscarinic receptors in various diseases, including cancer and pain.

Navigating the Complexities of the Nervous System

The nervous system is like a vast desert, filled with intricate pathways and hidden wonders. This study highlights the importance of exploring new ways to understand and modulate the cholinergic system, a critical component of this complex network. The research underscores the potential of these new pharmacological approaches to improve the lives of individuals suffering from a range of neurological and other diseases.

Dr.Camel's Conclusion

This research sheds light on the exciting field of cholinergic pharmacology, highlighting the potential of new drug targets to address a range of neurological and other diseases. The study underscores the importance of ongoing research to better understand the complex workings of the cholinergic system and to develop effective therapies for individuals suffering from these conditions.
Date :
  1. Date Completed 2014-09-30
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23597304

DOI: Digital Object Identifier

NIHMS837218

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Languages

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