In vitro evidence for mycophenolic acid dose-related cytotoxicity in human retinal cells.

Author: AcquestaFelipe B, DamicoFrancisco Max, GasparinFabio, KenneyMaria C, KuppermannBaruch D, TakahashiWalter Y, VenturaDora F, ZachariasLeandro C

Paper Details 
Original Abstract of the Article :
Mycophenolic acid (MPA) is an immunosuppressive agent that controls noninfectious uveitis. Intravitreal MPA delivery may be a potential adjuvant therapy in patients who have to discontinue steroid or immunosuppressive systemic therapy because of side effects. The aims of this study are to evaluate t...See full text at original site
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引用元:
https://doi.org/10.1097/IAE.0b013e31828b91e6

データ提供:米国国立医学図書館(NLM)

Evaluating the Cytotoxicity of Mycophenolic Acid in Retinal Cells

This research investigates the potential impact of mycophenolic acid (MPA), an immunosuppressive agent used to treat noninfectious uveitis, on retinal cells. The authors conducted in vitro studies to assess the cytotoxicity of MPA on human retinal pigment epithelium (ARPE-19) and human Muller cells (MIO M-1). This research provides valuable insights into the safety and efficacy of MPA in treating ophthalmic conditions.

Understanding the Potential Risks of MPA in Retinal Cells

This research highlights the importance of understanding the potential risks of MPA in treating ophthalmic conditions. The study found evidence of dose-related cytotoxicity of MPA in retinal cells, suggesting the need for careful monitoring and dosage adjustments to minimize potential adverse effects. This research emphasizes the importance of balancing therapeutic benefits with potential risks.

Navigating the Use of MPA in Ophthalmic Treatment

This research underscores the need for further investigation into the safety and efficacy of MPA in treating ophthalmic conditions. The findings provide a foundation for developing more targeted and personalized treatment approaches, minimizing potential risks while maximizing therapeutic benefits. This research highlights the importance of ongoing research and monitoring in ophthalmic drug development.

Dr. Camel's Conclusion

Imagine a vast desert, where delicate flora and fauna rely on a delicate balance for survival. MPA, like a desert wind, can have both beneficial and potentially harmful effects. This research is like a careful observation of this wind, understanding its impact on the delicate ecosystem of the retina. By understanding the potential risks and benefits of MPA, we can better navigate its use in treating ophthalmic conditions, ensuring the well-being of our patients.

Date :
  1. Date Completed 2014-03-05
  2. Date Revised 2013-10-24
Further Info :

Pubmed ID

23615344

DOI: Digital Object Identifier

10.1097/IAE.0b013e31828b91e6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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