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A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: challenges and therapeutic opportunities.

Author: CitromeLeslie, JamesSteven, LindenmayerJean-Pierre, NasrallahHenry, PucciMichael

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study examines the potential use of psychostimulants in treating negative symptoms of schizophrenia. While these drugs may show promise, their use requires careful consideration due to the risk of triggering psychotic symptoms.
Paper Details　
Original Abstract of the Article :
Primary negative symptoms of schizophrenia (NSS) contribute heavily to functional disability and treatment of these symptoms continues to be a major unmet need even when the positive (psychotic) symptoms are controlled. The modified dopamine (DA) hypothesis posits that positive symptoms are associat...See full text at original site
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引用元：
https://doi.org/10.1016/j.schres.2013.03.019

データ提供：米国国立医学図書館（NLM）

Psychostimulants: A Potential Oasis in the Desert of Negative Symptoms

This research explores the potential role of [psychostimulants] in treating the [negative symptoms of schizophrenia], which often contribute significantly to functional disability. The study reviews evidence suggesting that psychostimulants may have a therapeutic role in addressing negative symptoms, but also highlights the potential risks, including the possibility of triggering psychotic symptoms. The researchers propose that psychostimulants, when used cautiously and in combination with appropriate antipsychotics, may offer a promising avenue for improving the lives of individuals with schizophrenia.

Navigating the Complex Terrain of Schizophrenia: Addressing Negative Symptoms

Schizophrenia is a complex mental illness, often characterized by both positive and negative symptoms. While traditional antipsychotics effectively address positive symptoms, negative symptoms remain a significant challenge. This study explores the potential role of psychostimulants in addressing these persistent negative symptoms, potentially providing a much-needed oasis of relief for individuals struggling with this debilitating condition.

Unlocking the Potential of Psychostimulants: A New Approach to Schizophrenia

The study's findings offer a glimmer of hope for individuals with schizophrenia, particularly those struggling with persistent negative symptoms. Psychostimulants, when used cautiously and in combination with appropriate antipsychotics, may offer a promising approach for managing these challenging symptoms, potentially improving quality of life and promoting greater functional independence. Further research is crucial to fully understand the therapeutic potential of psychostimulants in addressing negative symptoms and optimizing treatment strategies.

Dr.Camel's Conclusion

This study explores the potential role of psychostimulants in treating the negative symptoms of schizophrenia. While further research is needed to establish their safety and efficacy, the findings suggest that psychostimulants, when used cautiously and in combination with appropriate antipsychotics, may offer a promising avenue for improving the lives of individuals with schizophrenia.

Date :
  1. Date Completed 2014-01-17
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

23619055

DOI: Digital Object Identifier

10.1016/j.schres.2013.03.019

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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