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The relationship between N-acetylcysteine, hyperbaric oxygen, and inflammation in a rat model of acetaminophen-induced nephrotoxicity.

Author: AgilliMehmet, AlpBilal Firat, AltayliErtan, AydinFevzi Nuri, AydinIbrahim, CayciTuncer, CermikHakan, OzkanEsin, TaslipinarMine Yavuz, ToygarMehmet, UcarFatma

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the effects of hyperbaric oxygen (HBO) alone and in combination with N-acetylcysteine (NAC) on inflammatory cytokines in a rat model of acetaminophen (APAP) toxicity. The findings suggest that both HBO and NAC, particularly in combination, can reduce renal damage and inflammation.
Paper Details　
Original Abstract of the Article :
An overdose of acetaminophen (APAP) produces acute tubular necrosis. The aim of this study was to observe the effects of hyperbaric oxygen (HBO) only and combined with N-acetylcysteine (NAC) on inflammatory cytokines in kidney. Thirty-two male Sprague-Dawley rats were divided into four groups: sham,...See full text at original site
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引用元：
https://doi.org/10.1007/s10753-013-9649-4

データ提供：米国国立医学図書館（NLM）

Acetaminophen Toxicity: A Desert of Renal Damage

The [treatment of acetaminophen overdose] is a critical area of medicine, as [acute tubular necrosis] can be a serious complication. This research investigates the effects of [hyperbaric oxygen (HBO) and N-acetylcysteine (NAC)] on [inflammatory cytokines] in a rat model of acetaminophen-induced nephrotoxicity. The authors explored the potential benefits of [HBO and NAC] in [reducing renal damage] and [mitigating inflammation] following acetaminophen overdose. Key findings include [the reduction of serum creatinine and urea levels] in rats treated with HBO and NAC, suggesting their potential therapeutic value.

A Oasis of Recovery: Fighting Acetaminophen-Induced Nephrotoxicity

This research offers hope for patients experiencing [acetaminophen-induced nephrotoxicity]. The study demonstrates that [HBO and NAC treatment] can [significantly reduce renal damage] and [mitigate inflammation] in rats exposed to acetaminophen overdose. The authors suggest that [combining HBO and NAC therapy] may offer a [more effective approach] to treating this condition. This research provides valuable insights into the [potential benefits of HBO and NAC] in the management of acetaminophen-induced nephrotoxicity.

A Sandstorm of Toxicity: Protecting the Kidneys

This research highlights the importance of [early intervention] and [appropriate treatment] in managing [acetaminophen overdose]. Understanding the potential benefits of [HBO and NAC] in reducing renal damage and mitigating inflammation can empower healthcare providers to [make informed decisions about patient care]. This research underscores the importance of [continuing to explore new therapeutic options] for patients experiencing acetaminophen-induced nephrotoxicity.

Dr.Camel's Conclusion

This research demonstrates the potential of HBO and NAC in mitigating acetaminophen-induced nephrotoxicity. The study highlights the need for further research to optimize treatment strategies and improve patient outcomes in this potentially life-threatening condition.

Date :
  1. Date Completed 2014-04-22
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23624663

DOI: Digital Object Identifier

10.1007/s10753-013-9649-4

Related Literature

Article Analysis
・Effects of acetylcysteine oral inhalation
SNS
PICO Info
in preparation
Languages

English

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