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Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

Author: GroothuisTom, HuijgensPeter, JanssenJeroen, JanssenLennert, KerkhovenRon, NeefjesJacques, NieuwlandMarja, OvaaHuib, PangBaoxu, QiaoXiaohang, RottenbergSven, VeldsArno, ZwartWilbert, van TellingenOlaf

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anthracycline drugs, a class of DNA topoisomerase II inhibitors, were found to promote histone eviction from open chromosomal areas, which can attenuate DNA repair and deregulate the transcriptome.
Paper Details　
Original Abstract of the Article :
DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a novel activity for the anthracycline class of DNA topoisomerase II inhibitors: histone eviction from open chromosomal ar...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674280/

データ提供：米国国立医学図書館（NLM）

Doxorubicin: A Powerful Anticancer Drug with a Novel Mechanism of Action

In the fight against [cancer], we constantly seek new and effective treatments. [Doxorubicin] is a well-established chemotherapy drug, and this research explores a novel mechanism by which it exerts its therapeutic effects.

This research delves into the unexpected activity of [anthracyclines], a class of DNA topoisomerase II inhibitors, including doxorubicin. The study reveals that anthracyclines can [promote histone eviction] from open chromosomal areas, independent of their ability to induce DNA double-strand breaks.

Unlocking a New Mechanism of Action

This research offers a deeper understanding of the complex interactions between doxorubicin and chromatin, suggesting a novel mechanism by which this drug exerts its therapeutic effects.

New Insights into Cancer Treatment

This research adds to our understanding of the intricate dance between cancer cells and chemotherapy drugs. It highlights the importance of exploring novel mechanisms of action for established drugs, potentially leading to more effective and targeted treatments in the future.

Dr. Camel's Conclusion

This study reveals a fascinating new mechanism of action for doxorubicin, highlighting its ability to promote histone eviction from open chromatin. This discovery sheds light on the complex interplay between chemotherapy drugs and chromatin, offering potential opportunities for more effective and targeted cancer therapies.

Date :
  1. Date Completed 2013-12-30
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

23715267

DOI: Digital Object Identifier

PMC3674280

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Article Analysis
・Side Effects of daunorubicin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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