Paper Details

  1. Home
  2. Paper Details

Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction.

Author: CohenKaren, MaartensGary, de WaalReneé

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

A systematic review of 27 studies found clear evidence of a causal relationship between nucleoside reverse transcriptase inhibitors (NRTIs), especially thymidine analogues, and lipoatrophy. Central fat gain, however, appears to be a consequence of treating HIV infection, not a specific antiretroviral drug.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Lipoatrophy and/or central fat gain are observed frequently in patients on antiretroviral therapy (ART). Both are assumed to be antiretroviral adverse drug reactions. METHODS: We conducted a systematic review to determine whether fat loss or gain was more common in HIV-infected patients...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665842/

データ提供：米国国立医学図書館（NLM）

Antiretroviral Therapy: Navigating the Shifting Sands of HIV Treatment

The treatment of HIV/AIDS is a constant journey through a shifting desert landscape, where new challenges and discoveries constantly emerge. This study delves into the potential side effects of antiretroviral therapy (ART), exploring the impact of these medications on fat distribution in individuals with HIV.

The researchers conducted a systematic review of studies examining the relationship between ART and lipodystrophy, a condition characterized by fat loss or redistribution. The results were like a shifting sand dune, revealing that ART was associated with lipoatrophy, a loss of fat in the limbs, but not with central fat gain.

Finding Stability in the Shifting Sands: Understanding ART's Effects on Fat Distribution

This review emphasizes the importance of understanding the potential side effects of ART. It's like navigating a shifting desert landscape – it's essential to be aware of the potential hazards and find ways to mitigate them.

A Constant Journey: Managing ART's Side Effects

The findings of this review highlight the need for continued monitoring and management of potential side effects associated with ART. It's a reminder that the desert of HIV treatment is a constant journey, requiring ongoing vigilance and adaptation.

Dr.Camel's Conclusion

This review explores the complex relationship between ART and fat distribution, highlighting the need for careful monitoring and management of potential side effects. It's a reminder that the desert of HIV treatment is a constant journey, requiring ongoing vigilance and adaptation to ensure the best possible outcomes.

Date :
  1. Date Completed 2014-01-10
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

23723990

DOI: Digital Object Identifier

PMC3665842

Related Literature

Article Analysis
・Side Effects of stavudine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.