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Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial.

Author: , BrodmerkelCarrie, DoyleMittie K, GottliebAlice B, KavanaughArthur, LiShu, McInnesIain B, MendelsohnAlan M, PuigLluís, RahmanProton, RitchlinChristopher, WangYuhua

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the safety and effectiveness of ustekinumab, a medication targeting a specific protein involved in inflammation, in treating active psoriatic arthritis, a condition affecting joints, tendons, and ligaments in people with psoriasis.
Paper Details　
Original Abstract of the Article :
Many patients with psoriasis develop psoriatic arthritis, a chronic inflammatory disease that afflicts peripheral synovial, axial, and entheseal structures. The fully human monoclonal antibody ustekinumab is an efficacious treatment for moderate-to-severe plaque psoriasis. We did a randomised, place...See full text at original site
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引用元：
https://doi.org/10.1016/S0140-6736(13)60594-2

データ提供：米国国立医学図書館（NLM）

Ustekinumab: A Promising Treatment for Psoriatic Arthritis

Psoriatic arthritis, a debilitating inflammatory disease, affects many people who also have psoriasis. This study investigates the safety and efficacy of ustekinumab, a fully human monoclonal antibody, as a treatment for active psoriatic arthritis.

Positive Results for Ustekinumab in Psoriatic Arthritis

The results of this phase 3 clinical trial show that ustekinumab is effective in treating active psoriatic arthritis. The study found that ustekinumab, when compared to placebo, demonstrated significant improvements in various measures of disease activity, including joint pain, swelling, and stiffness. This provides strong evidence for the effectiveness of ustekinumab in managing this challenging condition.

Hope for Patients with Psoriatic Arthritis

The study's findings offer hope for patients with psoriatic arthritis who are seeking effective treatment options. This research suggests that ustekinumab could be a valuable tool for managing the symptoms and improving the quality of life for individuals living with this condition. This discovery underscores the importance of ongoing research in developing innovative therapies for autoimmune diseases.

Dr.Camel's Conclusion

This study presents compelling evidence for the effectiveness of ustekinumab in treating active psoriatic arthritis. The positive findings offer hope for patients seeking relief from the debilitating symptoms of this inflammatory condition. The research provides a strong foundation for future investigations into the use of ustekinumab as a viable therapeutic option for psoriatic arthritis.

Date :
  1. Date Completed 2013-09-16
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

23769296

DOI: Digital Object Identifier

10.1016/S0140-6736(13)60594-2

Related Literature

Article Analysis
・Effective treatment of psoriatic arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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