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Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis.
Author: HanakSusan, Iglesias-BregnaDeborah, JiZhongqi, LiuLi, McMonagle-StruckoKathleen, PettyMargaret, ZhangDonghui
Original Abstract of the Article :
Teriflunomide is a once-daily oral immunomodulatory agent recently approved in the United States for the treatment of relapsing multiple sclerosis (RMS). This study investigated neurophysiological deficits in descending spinal cord motor tracts during experimental autoimmune encephalomyelitis (EAE; ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1124/jpet.113.205146
データ提供:米国国立医学図書館(NLM)
Teriflunomide's Impact on Motor-Evoked Potentials in Experimental Autoimmune Encephalomyelitis
Multiple sclerosis (MS) is a complex and debilitating neurological condition, like a desert storm that disrupts the delicate pathways of the brain. This study investigates the effects of teriflunomide, an immunomodulatory agent, on motor function in a rat model of experimental autoimmune encephalomyelitis (EAE), a model of MS. The researchers examined the impact of both prophylactic and therapeutic teriflunomide treatment on motor-evoked potentials, a measure of nerve function. The study found that teriflunomide significantly reduced EAE disease scores and prevented deficits in descending spinal cord motor tracts, suggesting its potential for treating MS.
Fighting the Desert Storm: Teriflunomide's Potential in Treating Multiple Sclerosis
The study highlights the potential of teriflunomide in treating MS, specifically its ability to mitigate motor function deficits. The findings suggest that teriflunomide could be a valuable tool for managing MS, potentially slowing disease progression and improving quality of life. It's like a desert traveler finding a resilient camel breed, able to withstand the harsh conditions and navigate the challenging terrain.
Navigating the Desert of MS: Understanding Treatment Options and Research
MS is a complex and challenging condition. This study highlights the importance of ongoing research in finding effective treatments. Teriflunomide shows promise as a potential therapeutic agent for MS, offering hope for individuals struggling with this debilitating disease. It's like discovering a hidden oasis in the desert, providing a respite from the harsh realities of MS.
Dr. Camel's Conclusion
This study explores the potential of teriflunomide in treating MS and provides valuable insights into the complex mechanisms underlying this neurological condition. It emphasizes the importance of ongoing research and the search for effective treatments for MS. As a wise camel traveler, I always encourage individuals facing MS to seek the best possible care and support.
Date :
- Date Completed 2013-11-25
- Date Revised 2022-03-10
Further Info :
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