Paper Details

  1. Home
  2. Paper Details

Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor.

Author: BarbhaiyaR H, GleasonC R, PittmanK A, ShuklaU A, ShyuW C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cefprozil and cefaclor are oral cephalosporin antibiotics. This study evaluated the effect of food on their pharmacokinetics. Food did not significantly affect the pharmacokinetics of cefprozil. However, food significantly reduced the peak concentration and prolonged the time to reach peak concentration of cefaclor.
Paper Details　
Original Abstract of the Article :
The objective of this study was to assess the effects of food on the pharmacokinetics of cefprozil and cefaclor. A group of 12 healthy male volunteers received a single 250-mg dose of cefprozil or cefaclor under fasting conditions as well as after the intake of food. There was a 1-week washout perio...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1128/AAC.34.6.1210

データ提供：米国国立医学図書館（NLM）

Cefprozil and Cefaclor: A Culinary Adventure in the Desert of Pharmacology

Antibiotics are essential tools in the fight against bacterial infections. This study, like a discerning desert gourmand, examines the effects of food on the pharmacokinetics of cefprozil and cefaclor. The researchers found that cefprozil's absorption was not significantly affected by food, while cefaclor's absorption was significantly reduced. This suggests that cefprozil can be taken with or without food, while cefaclor might be better taken on an empty stomach. It's like choosing the right desert delicacy - some flavors are best enjoyed alone, while others pair well with a hearty meal.

Understanding Food-Drug Interactions

This research highlights the importance of considering food-drug interactions. The study demonstrates that the presence of food can affect the absorption of certain antibiotics. It's a reminder that even the simplest desert meal can have a profound impact on the journey of a drug through the body.

Optimizing Antibiotic Therapy

This study provides valuable insights into the optimal administration of cefprozil and cefaclor. It emphasizes the importance of considering food-drug interactions and tailoring administration based on individual needs and the specific drug involved. It's like finding the perfect balance in a desert oasis - understanding the impact of different factors is essential for achieving the best possible outcomes.

Dr.Camel's Conclusion

This research, like a camel caravan navigating a diverse desert landscape, reveals the intricate interplay of food and medication. By understanding these interactions, we can optimize antibiotic therapy and ensure its effectiveness in the fight against bacterial infections.

Date :
  1. Date Completed 1990-10-02
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

2393283

DOI: Digital Object Identifier

10.1128/AAC.34.6.1210

Related Literature

Article Analysis
・Effects of cefprozil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.