Effects of triclabendazole on secretion of danofloxacin and moxidectin into the milk of sheep: role of triclabendazole metabolites as inhibitors of the ruminant ABCG2 transporter.

Triclabendazole: A Flukicide with Implications for Drug Secretion into Milk

This study investigates the potential of triclabendazole (TCBZ), a common flukicide, to interfere with the secretion of other drugs into milk. The researchers focused on the ABCG2 transporter, a crucial player in drug-drug interactions that affect milk secretion. They examined the inhibitory effects of TCBZ metabolites on both bovine and ovine ABCG2 variants in vitro and the impact of TCBZ coadministration on the secretion of danofloxacin and moxidectin into sheep milk.

Triclabendazole: A Flukicide that Can Impact Drug Secretion into Milk

The study demonstrated that TCBZ metabolites effectively inhibit ruminant ABCG2. This inhibition was observed in both the bovine and ovine variants of the transporter. Importantly, the researchers found that coadministration of TCBZ with moxidectin resulted in significantly reduced levels of moxidectin in sheep milk, highlighting the potential for drug-drug interactions.

Understanding Drug Interactions in Milk

This research highlights the importance of considering potential drug interactions when administering medications to lactating animals. The study's findings suggest that TCBZ may interfere with the secretion of certain drugs into milk, potentially affecting the health of both the mother and offspring. As Dr. Camel, I am constantly reminded of the complex interplay between drugs and the body. This study underscores the need for careful consideration of medication interactions, particularly in vulnerable populations like lactating animals.

Dr.Camel's Conclusion

This research provides valuable insights into the potential of triclabendazole to affect drug secretion into milk. The study highlights the importance of considering drug-drug interactions, particularly when administering medications to lactating animals. Further research is needed to explore the full extent of these interactions and develop strategies for mitigating potential risks.