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Aqueous humor penetration of ketorolac formulated in DuraSite or DuraSite 2 delivery systems compared to Acular LS in rabbits.
Author: BowmanLyle M, HosseiniKamran, HouEddie, ShafieeAfshin
Original Abstract of the Article :
PURPOSE: To evaluate the ocular penetration of ISV-304 (ketorolac tromethamine) formulated in DuraSite(®) or DuraSite(®) 2 compared to Acular LS(®) (0.4% ketorolac ophthalmic solution) in rabbits. METHODS: The left eye of rabbits received a single topical instillation of either ISV-304 (0.2% and 0....See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1089/jop.2013.0016
データ提供:米国国立医学図書館(NLM)
DuraSite: Enhancing Ketorolac's Ocular Penetration
We're delving into the realm of ophthalmology, specifically the delivery of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), for treating eye conditions. This study focused on comparing the effectiveness of different formulations of ketorolac, employing a rigorous approach that involved testing on rabbits. Imagine a group of camels, each carrying a different type of load, carefully traversing a challenging desert landscape.
DuraSite: A Superior Delivery System
The study found that DuraSite and DuraSite 2 formulations of ketorolac significantly improved the drug's ability to penetrate the eye compared to the traditional Acular LS formulation. This means patients could potentially experience better treatment outcomes with less frequent dosing. Think of it as a well-constructed camel saddle, designed to optimize the distribution of weight, leading to a smoother and more efficient journey across the desert.
Better Treatment, Fewer Side Effects
These findings suggest that the DuraSite formulations could potentially reduce side effects associated with topical NSAIDs. This is a significant advancement, as eye drops are often associated with some discomfort or irritation. Just as a camel adapts to the desert's harsh conditions, this innovation allows for a more comfortable experience for patients.
Dr. Camel's Conclusion
This research offers a compelling argument for DuraSite formulations of ketorolac. It's a testament to the ongoing quest for better, safer, and more effective treatments. Like a camel caravan diligently making its way across the desert, we continue to refine our approaches, driven by a desire to improve patient outcomes.
Date :
- Date Completed 2014-08-01
- Date Revised 2022-03-17
Further Info :
Related Literature
English
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