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Total or Partial Knee Arthroplasty Trial - TOPKAT: study protocol for a randomised controlled trial.

Author: ArdenNigel, BeardDavid, CampbellHelen, CampbellMarion, CarrAndrew, CookJonathan, CooperCushla, DaviesLoretta, DollHelen, FitzpatrickRay, MurrayDavid, PriceAndrew

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Most knee osteoarthritis affects the inner part of the knee. There are two different surgical approaches for this: replacing the entire knee (total knee replacement, TKR) or just the affected part (unicompartmental knee replacement, UKR). While both are established procedures, there's limited evidence to determine which approach is best. This study aims to compare the effectiveness and cost of TKR vs. UKR for patients with osteoarthritis in the inner knee compartment.
Paper Details　
Original Abstract of the Article :
In the majority of patients with osteoarthritis of the knee the disease originates in the medial compartment. There are two fundamentally different approaches to knee replacement for patients with unicompartmental disease: some surgeons feel that it is always best to replace both the knee compartmen...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848560/

データ提供：米国国立医学図書館（NLM）

Total vs. Partial Knee Arthroplasty: A Tale of Two Procedures

Osteoarthritis (OA) is a degenerative joint disease that can cause significant pain and disability. Researchers in the field of orthopedics are constantly working to develop and refine surgical procedures that effectively address OA, aiming to alleviate pain, restore function, and improve patient quality of life. This study protocol outlines a randomized controlled trial comparing total knee replacement (TKR) to unicompartmental knee replacement (UKR) for patients with medial compartment OA. The study seeks to determine the relative clinical and cost-effectiveness of these two common surgical procedures.

A Comparative Approach to Knee Replacement

This study protocol highlights the need for a comparative approach to knee replacement surgery, recognizing that there is a lack of conclusive evidence regarding the relative effectiveness of TKR and UKR for patients with medial compartment OA. The study aims to address this knowledge gap by conducting a randomized controlled trial, comparing the clinical outcomes and costs associated with these two procedures. This research will provide valuable insights into the best surgical approach for patients with medial compartment OA, ultimately guiding clinicians in making more informed treatment decisions and improving patient care.

Implications for Knee Replacement Surgery

The results of this study will have important implications for knee replacement surgery, providing evidence-based guidance for clinicians when selecting the most appropriate procedure for patients with medial compartment OA. This research will also contribute to understanding the cost-effectiveness of these procedures, helping to inform healthcare resource allocation and optimize patient care. By providing a robust comparison of TKR and UKR, this study will help to advance the field of knee replacement surgery and improve patient outcomes.

Dr.Camel's Conclusion

This study protocol is like a well-planned caravan route, carefully navigating the complex landscape of knee replacement surgery. By comparing TKR and UKR in a controlled setting, the study aims to shed light on the best path forward for patients with medial compartment OA, ultimately leading to better outcomes and a smoother journey back to mobility.

Date :
  1. Date Completed 2014-11-04
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

24028414

DOI: Digital Object Identifier

PMC3848560

Related Literature

Article Analysis
・Effective treatment of knee replacement
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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