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A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach.

Author: CitromeLeslie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Newly approved oral antipsychotics, including iloperidone, asenapine, and lurasidone, offer potential benefits over existing agents but differ in their side effect profiles. Lurasidone appears to minimize weight gain and metabolic abnormalities, while other agents have varying effects on QT interval, akathisia, and sedation.
Paper Details　
Original Abstract of the Article :
Evidence-based medicine (EBM) is a broad concept, but the key elements include the incorporation of clinical judgment (which requires clinical experience) together with relevant scientific evidence while remaining mindful of the individual patient's values and preferences. Using the framework and ph...See full text at original site
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引用元：
https://doi.org/10.1007/s40263-013-0105-7

データ提供：米国国立医学図書館（NLM）

A New Generation of Antipsychotics: Navigating the Landscape of Mental Health Treatment

Antipsychotic medications are crucial for the management of mental health conditions. This systematic review provides a comprehensive overview of the pharmacology, efficacy, and tolerability of recently approved and upcoming oral antipsychotics. The authors use an evidence-based medicine approach to critically evaluate the available data on these agents, focusing on clinically relevant issues such as weight gain, metabolic abnormalities, sedation, extra-pyramidal side effects, and drug-drug interactions. The review highlights the potential advantages and disadvantages of these new antipsychotics compared to existing medications, providing valuable insights for clinicians prescribing these medications.

A New Era in Antipsychotic Treatment: Balancing Benefits and Risks

The review identifies lurasidone as a promising new antipsychotic, potentially best in class in terms of minimizing weight gain and metabolic changes. However, the review also highlights important considerations regarding the dosing frequency, titration requirements, and potential side effects associated with other newly approved or upcoming antipsychotics, such as iloperidone, asenapine, and cariprazine.

Making Informed Choices: Understanding the Nuances of Antipsychotic Treatment

This review provides a valuable resource for clinicians navigating the complex landscape of antipsychotic treatment. The comprehensive overview of the pharmacology, efficacy, and tolerability of recently approved and upcoming oral antipsychotics empowers clinicians to make informed decisions about prescribing these medications, considering both the potential benefits and risks.

Dr.Camel's Conclusion

This systematic review offers a comprehensive analysis of the evolving landscape of antipsychotic medications. It provides valuable insights into the pharmacology, efficacy, and tolerability of recently approved and upcoming oral antipsychotics, equipping clinicians with the knowledge to make informed decisions about prescribing these medications, considering both the potential benefits and risks.

Date :
  1. Date Completed 2014-06-02
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

24062193

DOI: Digital Object Identifier

10.1007/s40263-013-0105-7

SNS
PICO Info
in preparation
Languages

English

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