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Topical application of recombinant platelet-derived growth factor increases the rate of healing and the level of proteins that regulate this response.

Author: BlalockTimothy D, ChinGloria, GandhiKavita, GowdaSantosh, MastBruce A, SchultzGregory S, WeinsteinDavid A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Platelet-derived growth factor (PDGF) accelerated wound healing in both normal and ischemic wounds in rats, suggesting its potential in promoting wound healing in conditions like ischemia.
Paper Details　
Original Abstract of the Article :
A bipedicle ischaemic rat skin flap model was used to study the effects of daily topical applications of platelet-derived growth factor (PDGF) on the healing of ischaemic wounds. Levels of tumour necrosis factor-alpha (TNFA), interleukin 1-beta (IL1B) and both the latent and active forms of matrix m...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950648/

データ提供：米国国立医学図書館（NLM）

Topical PDGF: A Beacon of Hope in the Desert of Wound Healing

Wound healing is a complex process that can be impaired by factors like ischemia. This study investigates the effects of topical application of recombinant platelet-derived growth factor (PDGF) on wound healing in a rat model of ischemic wounds. The researchers examined the impact of PDGF on wound healing rates and the expression of key proteins involved in the healing process. This research is like searching for a way to restore life to a barren desert, seeking solutions to promote healing and regeneration.

PDGF: A Potential Oasis in the Desert of Ischemic Wounds

The study found that topical PDGF significantly accelerated wound healing in both normal and ischemic wounds. It also reduced the levels of inflammatory cytokines and matrix metalloproteinases, which are associated with impaired healing. This research is like discovering a hidden oasis in the desert, providing the necessary resources to restore health and vitality.

Navigating the Desert of Wound Healing: The Promise of Topical PDGF

This study highlights the potential of topical PDGF as a therapeutic agent for promoting wound healing, particularly in the context of ischemia. The researchers' findings suggest that PDGF could be a valuable tool for treating chronic wounds and promoting tissue regeneration.

Dr.Camel's Conclusion

This study explores the potential of topical platelet-derived growth factor (PDGF) for accelerating wound healing in a rat model of ischemic wounds. It's like discovering a hidden oasis in the desert, providing the necessary resources to promote healing and regeneration. This research offers hope for developing new and effective treatments for chronic wounds, particularly those associated with impaired blood flow.
Date :
  1. Date Completed 2016-07-07
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24118782

DOI: Digital Object Identifier

PMC7950648

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Languages

English

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