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Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder.

Author: CiprianiAndrea, GeddesJohn, MacritchieKarine, ReidKeith, YoungAllan H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Bipolar disorder is a recurring mental illness that ranks among the top 30 causes of disability globally. Treatment focuses on preventing episodes and minimizing side effects. While lithium is often used, it doesn't work well for 20-40% of people. Valproate, an anticonvulsant drug, is also used and can help manage manic episodes. When choosing long-term treatment, effectiveness and side effects are important considerations.
Paper Details　
Original Abstract of the Article :
Bipolar disorder is a recurrent illness that is amongst the top 30 causes of disability worldwide and is associated with significant healthcare costs. In the past, emphasis was placed solely on the treatment of acute episodes of bipolar disorder; recently, the importance of episode prevention and of...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599863/

データ提供：米国国立医学図書館（NLM）

Valproic Acid for Bipolar Disorder: A Balancing Act

Bipolar disorder is a complex mental illness characterized by mood swings, and this study examines the effectiveness of valproic acid, a mood stabilizer, in the long-term management of this condition. The researchers conducted a comprehensive review of existing studies to evaluate the efficacy and safety of valproic acid in maintaining stability for individuals with bipolar disorder. Their goal was to provide evidence-based guidance for clinicians on the appropriate use of valproic acid in this patient population.

A Potential Solution for Bipolar Disorder: Valproic Acid's Role

The review found that valproic acid is effective in preventing mood episodes in individuals with bipolar disorder, particularly in those who do not respond adequately to lithium, a traditional mood stabilizer. However, the review also highlighted potential side effects associated with valproic acid, such as liver problems, weight gain, and hair loss. The researchers emphasize the importance of carefully considering the potential benefits and risks of valproic acid before prescribing it to patients with bipolar disorder.

Managing Bipolar Disorder: A Journey of Balance

This research underscores the importance of individualized treatment approaches for bipolar disorder, a condition that requires careful monitoring and personalized management. Just as a camel caravan adapts to the changing terrain of the desert, patients with bipolar disorder need to work closely with their physicians to find the most effective treatment strategies. This includes considering lifestyle changes, medication adjustments, and regular therapy sessions to maintain mental well-being.

Dr.Camel's Conclusion

This comprehensive review of literature examines the use of valproic acid in the maintenance treatment of bipolar disorder. The researchers, like seasoned guides navigating the complex desert of mental health, provide valuable insights into the potential benefits and risks of this mood stabilizer. The review emphasizes the importance of personalized treatment approaches for bipolar disorder, considering the individual needs and preferences of each patient.
Date :
  1. Date Completed 2014-04-28
  2. Date Revised 2023-10-12
Further Info :

Pubmed ID

24132760

DOI: Digital Object Identifier

PMC6599863

Related Literature

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・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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