Paper Details 
Original Abstract of the Article :
Centrally acting adrenergic agonists, by decreasing peripheral adrenergic activity, are effective antihypertensive agents. The older agents, however, especially methyldopa, have been associated with weight gain, clinical edema, and antihypertensive tolerance when used as monotherapy. While acute stu...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2417046

データ提供:米国国立医学図書館(NLM)

Effects of Alpha-2 Agonists on Renal Function in Hypertensive Humans

This study explores the effects of alpha-2 agonists, a class of medications used to treat hypertension, on renal function in humans. The researchers examined the potential impact of these drugs on renal blood flow, glomerular filtration rate, and sodium and water balance. The researchers focused on understanding the complex interplay between alpha-2 agonists and renal function.

The study found that alpha-2 agonists, while effective in reducing blood pressure, can have varying effects on renal function. While some studies have suggested that these drugs may lead to sodium retention and weight gain, other studies have shown that chronic administration can result in weight loss and a decrease in plasma volume. The researchers proposed that these seemingly contradictory effects could be explained by a balance between hypotension-related antinatriuresis and natriuretic activity due to reduced renal sympathetic tone.

Alpha-2 Agonists: Navigating the Complexities of Renal Function

This study highlights the complex relationship between alpha-2 agonists and renal function. While these drugs can be effective in treating hypertension, it's important to carefully consider the potential impact on renal function and to monitor patients closely for any adverse effects.

Understanding the Role of Alpha-2 Agonists in Hypertension

Alpha-2 agonists are a class of medications used to treat hypertension by reducing peripheral adrenergic activity. This study explores the potential effects of these drugs on renal function and provides valuable insights into the mechanisms involved. It's important to consult with a qualified healthcare professional to determine the appropriate treatment for your individual needs and to discuss any potential risks and benefits.

Dr.Camel's Conclusion

This research sheds light on the intricate relationship between alpha-2 agonists and renal function, reminding us that even seemingly simple interventions can have complex effects on the body. This research underscores the importance of understanding the mechanisms of action of medications to optimize treatment strategies and minimize potential risks.

Date :
  1. Date Completed 1986-02-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2417046

DOI: Digital Object Identifier

2417046

Related Literature

SNS
PICO Info
in preparation
Languages

English

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