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Glucocorticoid-induced osteoporosis: an update on effects and management.

Author: BinkleyNeil, BuehringBjoern, BusseWilliam, ViswanathanRavi

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the epidemiology and pathophysiology of glucocorticoid-induced osteoporosis (GIO) and its management in patients with asthma. Glucocorticoids can impact bone health, and effective options for detection and management of GIO exist.
Paper Details　
Original Abstract of the Article :
Glucocorticoids remain a cornerstone of guideline-based management of persistent asthma and allergic diseases. Glucocorticoid-induced osteoporosis (GIO) is the most common iatrogenic cause of secondary osteoporosis and an issue of concern for physicians treating patients with inhaled or oral glucoco...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaci.2013.08.040

データ提供：米国国立医学図書館（NLM）

Glucocorticoid-Induced Osteoporosis: A Bone-Weakening Threat

The human skeletal system, like the strong and sturdy bones of a desert camel, plays a crucial role in maintaining our mobility and overall health. This study explores the risks and management strategies for glucocorticoid-induced osteoporosis (GIO), a common side effect of long-term glucocorticoid therapy. The researchers examine the underlying mechanisms of GIO and review the latest guidelines for diagnosis and treatment.

Understanding the Mechanism of GIO

The study reveals that glucocorticoids can negatively impact bone health by affecting the activity of osteoclasts, osteoblasts, and osteocytes, leading to bone loss and increased risk of fractures. The researchers emphasize the importance of early detection and management of GIO to prevent potentially debilitating fractures.

Implications for Osteoporosis Management

This research highlights the importance of considering bone health when prescribing long-term glucocorticoid therapy. Healthcare providers should carefully monitor bone mineral density in patients receiving these medications and implement preventative measures to minimize the risk of GIO.

Dr.Camel's Conclusion

The desert of osteoporosis research is a vital area of focus, as bone health is essential for overall well-being. This study underscores the importance of recognizing and managing the risks associated with GIO, ensuring that patients receiving glucocorticoids receive appropriate care and maintain strong and resilient bones.

Date :
  1. Date Completed 2014-01-07
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

24176682

DOI: Digital Object Identifier

10.1016/j.jaci.2013.08.040

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English

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