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Administration of chromium(III) and manganese(II) as a potential protective approach against daunorubicin-induced cardiotoxicity: in vitro and in vivo experimental evidence.

Author: LiuYang, WangDebin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the interaction between daunorubicin (DNR) and cardiac myosin (CM) in the presence of chromium(III) (Cr(3+)) and manganese(II) (Mn(2+)).
Paper Details　
Original Abstract of the Article :
Daunorubicin (DNR) is a widely used antitumor drug, but its application is limited because of its cardiotoxic side effects. The present study was designed to investigate the interaction between DNR and cardiac myosin (CM) in the presence of chromium(III) (Cr(3+)) and manganese(II) (Mn(2+)) using flu...See full text at original site
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引用元：
https://doi.org/10.1007/s12011-013-9851-0

データ提供：米国国立医学図書館（NLM）

Protecting the Heart in the Desert of Cancer Treatment

The journey through cancer treatment can be a challenging one, with the side effects of chemotherapy often mirroring the harsh conditions of a desert. This study, like a search for a hidden oasis in this vast landscape, explores the potential protective effects of chromium(III) and manganese(II) against daunorubicin-induced cardiotoxicity. The study sought to understand whether these elements could help mitigate the heart damage associated with this powerful cancer drug.

A Shield Against Cardiotoxicity

The study found that both chromium(III) and manganese(II) significantly decreased the binding force between daunorubicin and cardiac myosin, alleviating the cardiotoxicity caused by the drug. These findings offer a glimmer of hope for protecting the heart during cancer treatment, potentially reducing the risk of long-term cardiac damage.

A More Manageable Journey

This study provides a potential roadmap for navigating the challenges of cancer treatment, suggesting that chromium(III) and manganese(II) could play a valuable role in protecting the heart from the damaging effects of chemotherapy. While further research is needed to confirm these findings in humans, this study offers a promising avenue for developing strategies that can make the journey through cancer treatment a bit more manageable.

Dr.Camel's Conclusion

This study provides a promising oasis in the desert of cancer treatment, highlighting the potential protective effects of chromium(III) and manganese(II) against daunorubicin-induced cardiotoxicity. While more research is needed to confirm these findings in humans, this study offers a glimmer of hope for those facing the challenges of cancer treatment. The desert of cancer research is vast, but this study provides a valuable roadmap for navigating the complex terrain and finding solutions that can make the journey a bit more manageable.

Date :
  1. Date Completed 2014-07-21
  2. Date Revised 2013-12-02
Further Info :

Pubmed ID

24189981

DOI: Digital Object Identifier

10.1007/s12011-013-9851-0

Related Literature

Article Analysis
・Side Effects of daunorubicin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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