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Medical approaches to non-melanoma skin cancer.

Author: BhattKarishma, LacarrubbaFrancesco, MicaliGiuseppe, NascaMaria Rita

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Medical therapy is an alternative treatment option for some forms of non-melanoma skin cancer (NMSC). Topical treatments are preferred over invasive procedures in specific cases, especially for multifocal lesions, unclear lesion edges, risk of keloids, surgical risk factors, and localization in areas like the face and décolletage, as cosmetic outcomes are generally excellent. Molecularly targeted therapy offers a promising alternative to conventional cytotoxic chemotherapy for advanced and metastatic NMSC. The paper analyzes the mechanisms of action, formulations, official and off-label indications, efficacy, side effects, and contraindications of medical treatments used for NMSC, including 5-fluorouracil, imiquimod, diclofenac, ingenol mebutate, resiquimod, piroxicam, dobesilate, betulinic acid, vismodegib, cetuximab, gefitinib, and cytotoxic chemotherapy.
Paper Details　
Original Abstract of the Article :
Medical therapy represents an alternative treatment approach that can be considered for some forms of non-melanoma skin cancer (NMSC). In selected cases, topical treatments are preferable to invasive procedures, especially in the case of multifocal lesions, unclear lesion edges, risk of keloids, sur...See full text at original site
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引用元：
https://doi.org/10.1586/14737140.2013.856759

データ提供：米国国立医学図書館（NLM）

Treating Non-Melanoma Skin Cancer: A Multifaceted Approach

Non-melanoma skin cancer (NMSC) is a prevalent concern, with millions of cases diagnosed each year. This study explores the diverse landscape of medical treatments for NMSC, highlighting the array of options available to combat this disease. The researchers delve into the mechanisms of action, formulations, and clinical indications of various therapies, including topical treatments, molecularly targeted therapies, and cytotoxic chemotherapy.

Beyond Surgery: Medical Therapies for NMSC

The study emphasizes the role of medical therapy as a viable alternative to surgery for selected cases of NMSC. Topical treatments offer a less invasive approach, particularly for multifocal lesions or areas where surgery may pose cosmetic risks. This is like a camel caravan choosing a scenic detour rather than navigating treacherous mountain passes. In the case of advanced NMSC, molecularly targeted therapy presents a promising option, focusing on specific molecular pathways involved in tumor growth, much like a skilled archer targeting a specific spot on a distant target.

Finding the Right Treatment for NMSC

The study provides a comprehensive overview of different medical treatments for NMSC, highlighting the importance of individualizing therapy based on the specific characteristics of the cancer and the patient's overall health. It's like a camel caravan selecting the optimal route based on the terrain and the caravan's strength. The researchers emphasize the need for further research to refine existing treatments and develop new therapies, ensuring that NMSC patients have access to the best possible care.

Dr.Camel's Conclusion

This study guides us through the desert of NMSC treatment options, offering a comprehensive overview of medical therapies available. While surgery remains a mainstay, the researchers emphasize the potential of medical treatments, especially for specific situations. Remember, just as a camel caravan navigates diverse terrain, the journey of treating NMSC requires a careful selection of the right approach for each individual patient.

Date :
  1. Date Completed 2014-08-13
  2. Date Revised 2013-11-18
Further Info :

Pubmed ID

24236820

DOI: Digital Object Identifier

10.1586/14737140.2013.856759

SNS
PICO Info
in preparation
Languages

English

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