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Effects of a non-focal plasticity protocol on apathy in moderate Alzheimer's disease: a randomized, double-blind, sham-controlled trial.

Author: ApolinarioDaniel, BruckiSonia Maria, FregniFelipe, LeiteRenata Elaine Paraizo, LopesLeonardo, MagaldiRegina Miksian, MorilloLilian Shafirovitz, Nakamura-PalaciosEster Miyuki, NitriniRicardo, SalesManuela Castro, SuemotoClaudia Kimie

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of repetitive transcranial direct current stimulation (tDCS) on apathy in moderate Alzheimer's disease (AD) patients. The study found that tDCS had no effect on apathy in elderly patients with moderate AD.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Apathy is the most common neuropsychiatric symptom in Alzheimer's disease (AD) and it is associated with changes in prefrontal neural circuits involved with generation of voluntary actions. To date no effective treatment for apathy has been demonstrated. OBJECTIVE: We aimed to investiga...See full text at original site
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引用元：
https://doi.org/10.1016/j.brs.2013.10.003

データ提供：米国国立医学図書館（NLM）

Apathy in Alzheimer's Disease: A Desert of Motivation

Alzheimer's disease (AD), a neurodegenerative disorder, casts a long shadow over the desert of cognitive decline. This research explores the debilitating symptom of apathy, a common feature of AD, and investigates the potential of repetitive transcranial direct current stimulation (tDCS) as a therapeutic intervention. The authors, like intrepid explorers seeking to illuminate the dark corners of AD, delve into the neural mechanisms underlying apathy, seeking to identify effective treatments for this challenging symptom.

A Search for Relief in the Desert of Apathy

The study, involving 40 patients with moderate AD, found that tDCS, a non-invasive brain stimulation technique, did not have a significant effect on apathy. This finding suggests that, with the parameters used in this study, tDCS may not be a viable treatment option for apathy in AD. While this research may not have yielded the desired results, it provides valuable insights into the complexities of apathy and the ongoing quest for effective treatments.

Navigating the Desert of Alzheimer's Disease

Apathy is a challenging symptom of AD, but there are other strategies that may be helpful in managing this condition. Consult with a healthcare professional to discuss personalized approaches for managing apathy, including behavioral therapies, medication, and lifestyle interventions.

Dr.Camel's Conclusion

This study highlights the complexity of apathy in AD and the ongoing search for effective treatments. While tDCS did not demonstrate significant benefits in this particular study, the research continues to shed light on the neural mechanisms underlying apathy, paving the way for future research and potential breakthroughs. Like a desert traveler facing a challenging terrain, researchers continue to explore new paths and strategies in the fight against AD and its debilitating symptoms.

Date :
  1. Date Completed 2015-05-08
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

24262299

DOI: Digital Object Identifier

10.1016/j.brs.2013.10.003

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・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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