Clinical, functional, and radiographic implications of time to treatment response in patients with early rheumatoid arthritis: a posthoc analysis of the PREMIER study.

Author: GuéretteBenoît, HaraouiBoulos, KavanaughArthur, KeystoneEdward C, LiuShufang, MozaffarianNeelufar

Paper Details 
Original Abstract of the Article :
Rheumatoid arthritis (RA) treatment recommendations suggest target attainment within the first 3 months of therapy, yet delayed clinical responses can occur. This analysis assessed the longterm clinical, functional, and radiographic outcomes associated with delayed responses to methotrexate (MTX) mo...See full text at original site
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引用元:
https://doi.org/10.3899/jrheum.121468

データ提供:米国国立医学図書館(NLM)

Time to Treatment Response in Early Rheumatoid Arthritis: Navigating the Desert of Chronic Inflammation

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can significantly impact the quality of life. This study delves into the complex landscape of RA treatment, exploring the importance of timely and effective responses to therapy. Researchers analyzed data from the PREMIER study, focusing on the long-term clinical, functional, and radiographic outcomes associated with delayed responses to methotrexate (MTX) monotherapy or the combination of adalimumab (ADA) + MTX. The results revealed that delayed responses to treatment can have significant implications for long-term outcomes, emphasizing the importance of achieving target attainment within the first three months of therapy.

Early Treatment Response: A Key to Navigating the Desert of RA

The findings of this study highlight the importance of early and effective treatment in managing RA. Delaying treatment response can have long-term consequences for joint damage, functional limitations, and overall health. The study reinforces the current recommendations for achieving target attainment within the first three months of therapy, underscoring the importance of timely and effective intervention in combating the relentless march of chronic inflammation.

Understanding the Time Factor: A Journey Through the Desert of RA

The study provides valuable insights into the importance of time in RA treatment. It emphasizes the need for close monitoring and prompt intervention to ensure optimal outcomes for patients. By understanding the implications of delayed responses, patients and their healthcare providers can work together to navigate the desert of RA and achieve the best possible results.

Dr.Camel's Conclusion

This research highlights the importance of early treatment response in achieving optimal outcomes for patients with early RA. It emphasizes the need for timely and effective interventions to prevent long-term joint damage and functional limitations. The findings provide valuable information for both patients and healthcare providers, enabling them to work together to navigate the complex terrain of RA and create a more fulfilling journey through the desert of chronic inflammation.

Date :
  1. Date Completed 2014-09-30
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

24293583

DOI: Digital Object Identifier

10.3899/jrheum.121468

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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