Effective treatment of arthritis: A Synthesis of Findings from 132 Studies

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Original Abstract of the Article

Key Research Findings

Many studies have been conducted on the treatment of arthritis. 28 research found that TNF-α plays a key role in the pathogenesis of arthritis. 129 research highlighted the need for long-term use of therapeutic drugs that reduce joint pain with minimal adverse effects. 22 research suggested that intensive outpatient management for sustained control of disease activity might be more effective than routine outpatient care. 95 research found that while hyaluronic acid and other treatments showed symptomatic efficacy, they didn't demonstrate disease modification. 109 research suggested that corticotropin injections could be an effective treatment for arthritis. 117 research explored the potential of arthroscopic synovectomy of the wrist as a valuable treatment for local inflammation caused by wrist arthritis. 92 research emphasized the importance of analyzing and comparing the costs and benefits of emerging new treatments to optimize limited resources. 100 research pointed out that TNF-α inhibitors could increase the risk of infections. 43 research suggested that early treatment of arthritis could delay disease progression. 121 research highlighted the importance of non-pharmacological therapies in addition to medication for effective arthritis management. 62 research suggested that biological agents could be effective in patients who didn't respond well to conventional treatments. 110 research suggested that prednisolone could be effective for treating hand osteoarthritis. 108 research investigated the prognostic factors associated with positive response to DMARDs. 120 research emphasized the importance of choosing appropriate treatment based on the type of arthritis. 91 research found that the cost of treatment varied depending on the type of treatment. 10 research indicated that early treatment of arthritis can be effective in controlling disease progression. 30 research found that methotrexate could be effective for the early treatment of arthritis. 25 research stressed the importance of starting treatment early to effectively suppress inflammation. 47 research emphasized the importance of targeting treatments to achieve specific goals for effective arthritis management. 49 research found that infliximab is an effective treatment but is often expensive. 79 research indicated the importance of long-term treatment for optimal outcomes. 27 research found that etanercept and methotrexate could be effective treatments. 41 research highlighted the various therapeutic options available for arthritis. 66 research suggests that achieving treatment goals within the first three months of therapy is ideal. 94 research explored the potential effectiveness of ustekinumab for patients who didn't respond to initial treatments. 20 research studied the outcomes of using various DMARDs and corticosteroids for early treatment. 9 research found that methotrexate could be effective for treating arthritis. 127 research highlighted the importance of preventative measures for individuals at risk of developing arthritis. 65 research emphasized the effectiveness of TNF blockers for arthritis but highlighted the importance of understanding their safety. research found that infliximab could be an effective treatment option. 84 research investigated the potential link between genetic polymorphisms and treatment outcomes for methotrexate. 61 research found that early treatment could be effective in controlling inflammation. 18 research found that thermotherapy could be a valuable treatment option. 23 research emphasized the importance of aggressive treatment for arthritis. 57 research found that tocilizumab could be an effective treatment. 31 research noted that non-aspirin NSAIDs are used for pain and inflammation relief. 82 research found that prolonged intensive DMARD treatment can lead to high remission and low relapse rates. 34 research found that exercise therapy could be beneficial for treating arthritis. 80 research found that biological DMARDs are becoming increasingly favored in clinical practice. 1 research emphasized the importance of treatment during remission for sustaining remission and slowing down destructive processes in joints.

Treatment Summary

Treatments for arthritis include DMARDs (disease-modifying antirheumatic drugs), biologics, corticosteroids, hyaluronic acid, thermotherapy, exercise therapy, arthroscopic synovectomy, infliximab, etanercept, methotrexate, tocilizumab, ustekinumab, and prednisolone. 22 research suggested that intensive outpatient management could be more effective than routine care for controlling disease activity. 95 research showed that treatments like hyaluronic acid can relieve symptoms but don't modify disease progression. 109 research suggested that corticotropin injections could be an effective treatment. 82 research found that prolonged intensive DMARD treatment can lead to high remission and low relapse rates. 34 research found that exercise therapy could be beneficial for treating arthritis.

Benefits and Risks

Benefits Summary

Treatment for arthritis can offer benefits such as symptom relief, prevention of joint damage, and improvement in quality of life. 28 research found that TNF-α inhibitors can improve symptoms. 129 research explores treatments for reducing knee pain. 22 research showed that intensive management could control disease progression. 43 research suggested that early treatment could delay disease progression. 82 research found that prolonged treatment can lead to high remission rates and lower relapse rates. 34 research found that exercise therapy can improve symptoms.

Risk Summary

Treatment for arthritis can come with risks including infections, side effects, and high treatment costs. 100 research found that TNF-α inhibitors could increase infection risk. 49 research found that infliximab, while effective, can be expensive.

Comparison of Research

Commonalities in Research

Many studies emphasize the importance of early, intensive, and long-term treatment for arthritis. 22 , 43 , 82

Differences in Research

The treatments, target patient groups, and evaluation methods vary between studies. For example, 28 research found TNF-α inhibitors to be effective, while 100 research noted the potential increased infection risk associated with them.

Consistency and Contradictions in Results

There are both consistencies and contradictions in the research findings regarding treatment of arthritis. 28 , 100

Applying Findings in Daily Life

Treatment options for arthritis depend on factors such as the type of arthritis, symptoms, and lifestyle of the patient. 121 research highlights the importance of non-pharmacological therapies in addition to medication.

Limitations of Current Research

Research on arthritis treatment can have limitations such as small sample sizes and lack of long-term follow-up. 82 research found that prolonged treatment can lead to high remission rates and low relapse rates, but longer-term studies are needed to confirm this.

Future Research Directions

Future research on arthritis treatment should focus on developing new treatments, validating the effectiveness and safety of existing treatments, identifying predictive factors for treatment success, and improving patient quality of life. 108

Conclusion

There are many treatment options available for arthritis. The best treatment depends on factors such as type of arthritis, symptoms, and lifestyle. Consulting with a doctor for personalized advice is crucial for choosing the most suitable treatment. 121

Treatment List

DMARDs (disease-modifying antirheumatic drugs), biologics, corticosteroids, hyaluronic acid, thermotherapy, exercise therapy, arthroscopic synovectomy, infliximab, etanercept, methotrexate, tocilizumab, ustekinumab, prednisolone

Keywords
Benefit Keywords
Complete responses
Prolonged remission
Slower destructive processes
1
Mtx safety
RA treatment
2
Clinical improvement
Reduced corticosteroid dosage
Retarded joint deterioration
3
Good results
Less severe joint condition
4
Improved rheumatoid arthritis symptoms
5
RA improvement
Relatively safe
6
Improved erythrocyte sedimentation rate
Improved functional disability
Improved joint score
Reduced pain
8
MTX effective for RA
9
Improved rheumatoid arthritis treatment
10
Enhanced efficacy
Improved RA treatment
Improved rheumatoid arthritis treatment
Reduced joint damage
11
Rheumatoid arthritis treatment
12
Rheumatoid arthritis treatment
15
Palliative therapy
16
Effective on-demand dosing
Less GI side effects
Similar pain relief
17
Palliative therapy
18
Increased grip strength
Increased wrist dorsal flexion
Reduced morning stiffness
Reduced painful joints
Reduced swollen joints
19
Effective RA treatment
20
SpA treatment
21
Improved outcome in RA
22
Improved disease activity
Symptom control
23
Improved rheumatoid arthritis treatment
24
RA treatment
25
Disease activity suppression
RA pain reduction
26
Improved function
Reduced disease activity
Slowed radiographic progression
27
Improved psoriatic arthritis treatment
28
Reduced joint damage
Rheumatoid arthritis treatment
29
Joint damage retardation
RA diagnosis postponement
30
Pain relief
31
Improved rheumatoid arthritis treatment
32
Improved rheumatoid arthritis treatment
33
Improved aerobic capacity
Improved functional ability
Improved quality of life
34
Improved psoriasis and psoriatic arthritis
35
Improved rheumatoid arthritis treatment
36
Improved rheumatoid arthritis treatment
37
Early PsA diagnosis
38
Improved function
Pain relief
39
RA treatment
40
RA treatment
41
RA treatment
42
UA/early RA treatment
43
Improved function
Improved pain
44
Improved function
Improved pain
45
Better clinical outcomes
47
PA treatment
48
Cost-effective treatment
49
RA treatment
50
RA Symptom Relief
51
Cost-effective
Improved RA
52
RA treatment
53
RA treatment
54
Pain management for arthritis
55
Improved remission
Reduced disability
Reduced disease activity
Reduced joint damage
Reduced need for additional drugs
56
Treatment of rheumatoid arthritis
57
Treatment of early RA
58
Bioequivalent formulations
59
RA treatment
Radiological progression suppression
60
Reduced radiological progression
Suppressed disease activity
61
RA treatment
62
RA treatment
63
Clinical improvement
Improved ankle function
64
PsA treatment
65
Improved function
Reduced inflammation
66
RA treatment
67
RA treatment
68
Equivalent clinical benefits
Lower costs
69
OA treatment
71
RA treatment
73
Improved rheumatoid arthritis
74
Lower total costs
75
Improved RA treatment
Potential for better outcomes
RA treatment
76
Knee OA treatment
77
Damage prevention
Disease activity suppression
78
Drug-free remission
Functional improvement
Normalized survival
Radiographic damage prevention
79
JIA treatment
80
Psoriasis treatment
Psoriatic arthritis treatment
RA treatment
81
RA remission
Reduced RA flares
82
Improved disease activity
Reduced radiographic progression
83
Improved RA response to MTX
84
RA treatment
85
Osteoarthritis treatment
86
RA treatment
87
Improved RA treatment
88
RA treatment
89
Psoriatic arthritis treatment
90
RA treatment
91
New treatments
Psoriatic arthritis treatment
92
Biologic agents
RA treatment
93
Clinical improvement
Reduced adverse effects
94
Symptomatic efficacy for knee OA
95
DMARD therapy
RA treatment
Tight disease control
96
RA remission
97
Prognosis assessment
RA treatment
98
CS
HA
IA therapies
KOA treatment
PRP
99
JIA treatment
100
Alternative treatments
Arthritis treatment
101
RA treatment
Tofacitinib
102
MTX combination therapy
RA treatment
103
Disease improvement
104
RA response
105
Improved disease control
Improved functional capacity
Improved remission
106
Improved clinical outcomes
Reduced hospitalizations
Reduced work disability
107
Improved RA treatment
109
OA pain relief
110
Improved function
Reduced pain
111
Function improvement
Pain reduction
112
IA DMARDs
RA treatment
113
Medicinal plants
Natural alternative
Potential for RA treatment
RA treatment
114
RA treatment
115
Improved outcomes
116
RA pain relief
Wrist function improvement
117
RA activity
TCZ
118
Improved quality of life
Shared decision-making
119
JIA treatment
120
Improved quality of life
Shared decision-making
121
JIA treatment
122
DMARDs for rheumatoid arthritis
123
RA treatment
124
Improved quality of life
Improved work outcomes
125
Disease remission
126
RA treatment
127
Cost-effective b/tsDMARD use
128
KOA pain relief
Knee function
129
Rheumatoid arthritis treatment (certolizumab)
130
Improved RA response
131
Improved clinical remission
Reduced radiographic progression
132
Risk Keywords
Long-term effects
2
Azoospermia
Malignancy
Mutagenesis
3
Complications
4
Dizziness
GI symptoms
6
Adverse reactions
8
MTX toxicity
9
Corticosteroid dependence
Limited evidence
Need for replication
11
None reported
12
Limited evidence
14
Poor quality of trials
16
Treatment failures
20
Deterioration in function
23
Rheumatoid arthritis
24
C-reactive protein levels
HAQ deterioration
25
Adverse effects
26
Psoriatic arthritis
28
Combination therapy withdrawal
29
Insufficient evidence
Low quality studies
31
Rheumatoid arthritis
32
Rheumatoid arthritis
33
Rheumatoid arthritis
36
Rheumatoid arthritis
37
Infection risk
Liver damage
39
Over-treatment
40
Limited safety data
Placebo effects
44
Complications
Paucity of trials
45
No delay in RA development
No effect on remission
46
Adverse Events
51
Gastrointestinal risks
Liver risks
55
Adverse events
56
Side effects
60
Long-term benefit unclear
61
Implant failure
Non-union
64
Limited remission
Serious adverse events
69
No additional benefit
70
Ineffective treatment
72
Needs further research
Unclear effectiveness and safety
76
Drug-free remission
Remission
78
Dropout rate
79
Increased adverse events
83
MTX adverse events
84
NSAID side effects
Opiate side effects
86
Cost optimization
92
Medication cost
93
Heterogeneous cost-effectiveness estimates
No efficacy for disease modification
95
JIA diagnosis
100
Side effects
104
Herpes zoster
Retinal vein occlusion
105
Prednisolone side effects
110
Cartilage toxicity
Increased blood glucose
Increased infections
Reduced immune function
111
Needs further research
Potential for interactions
Side effects
Unclear effectiveness
114
Lipid profiles
118
Heterogeneity
131
Literature analysis of 132 papers
Positive Content
123
Neutral Content
3
Negative Content
6
Article Type
54
32
63
48
132
1.

[Treatment experience with rheumatoid arthritis patients during remission].

Author: SorokaN F

Complete responses
Prolonged remission
Slower destructive processes

A study of 94 rheumatoid arthritis (RA) patients found that a combined treatment regimen, addressing psychological factors and strengthening the immune system, led to more frequent and longer-lasting remissions. Destructive processes in the joints slowed down during remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

2.

Low-dose methotrexate in rheumatoid arthritis: effect and tolerance. An open trial and a double-blind randomized study.

Author: SzantoE

Mtx safety
RA treatment
Long-term effects

Weekly low-dose methotrexate (MTX) is a safe and effective treatment option for patients with severe rheumatoid arthritis (RA) who have not responded to conventional therapies. While long-term studies are needed to confirm its impact on joint damage, MTX has shown promise in slowing the progression of RA. However, potential side effects should be monitored closely.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis.

Author: CurreyH L, HarrisJ, MasonR M, WoodlandJ, BeveridgeT, RobertsC J, VereD W, DixonA S, DaviesJ, Owen-SmithB

Clinical improvement
Reduced corticosteroid dosage
Retarded joint deterioration
Azoospermia
Malignancy
Mutagenesis

A study of patients with early rheumatoid arthritis compared the effectiveness of azathioprine, cyclophosphamide, and gold. All three drugs resulted in similar improvements in symptoms, reduced corticosteroid use, and slowed joint damage over 18 months. Azathioprine was the easiest to manage, while cyclophosphamide may have been slightly more effective but caused infertility in men. The study concluded that these anti-proliferative drugs offer a viable alternative to gold therapy for rheumatoid arthritis, potentially allowing for earlier treatment. However, long-term risks of these drugs need to be considered.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Long-term study of management of rheumatoid arthritis.

Author: MillionR, KellgrenJ H, PooleP, JaysonM I

Good results
Less severe joint condition
Complications

A 10-year study comparing a program of rest and medication with a program of maintained activity and medication for rheumatoid arthritis found no significant difference in overall outcomes, except that the steroid group showed better clinical and radiological outcomes for several joints.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Second line (disease modifying) treatment in rheumatoid arthritis: which drug for which patient?

Author: CapellH A, PorterD R, MadhokR, HunterJ A

Improved rheumatoid arthritis symptoms

Gold, penicillamine, and sulphasalazine were equally effective in treating rheumatoid arthritis. Neither gender nor age influenced the response to treatment, but patients with a longer disease duration were more likely to stop treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

6.

Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial.

Author: KloppenburgM, BreedveldF C, TerwielJ P, MalleeC, DijkmansB A

RA improvement
Relatively safe
Dizziness
GI symptoms

Minocycline was found to be beneficial and relatively safe for treating rheumatoid arthritis (RA) in a 26-week study. The drug showed statistically significant improvement compared to placebo. The study involved 80 patients with active RA who had been previously treated with at least one disease-modifying antirheumatic drug.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.

Author: O'DellJ R, HaireC E, EriksonN, DrymalskiW, PalmerW, EckhoffP J, GarwoodV, MaloleyP, KlassenL W, WeesS, KleinH, MooreG F

Rheumatoid arthritis (RA) is a common condition that causes significant health problems. While single medications like methotrexate are often used, many patients do not respond well to these treatments. Despite limited research, many patients are treated with combinations of medications, even though there is limited evidence for their effectiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

The effectiveness of early treatment with "second-line" antirheumatic drugs. A randomized, controlled trial.

Author: van der HeideA, JacobsJ W, BijlsmaJ W, HeurkensA H, van Booma-FrankfortC, van der VeenM J, HaanenH C, HofmanD M, van Albada-KuipersG A, ter BorgE J, BrusH L, DinantH J, KruizeA A, SchenkY

Improved erythrocyte sedimentation rate
Improved functional disability
Improved joint score
Reduced pain
Adverse reactions

Early introduction of slow-acting antirheumatic drugs (SAARDs) was more beneficial than delayed introduction for patients with recently diagnosed rheumatoid arthritis, resulting in improved outcomes for functional disability, pain, joint score, and erythrocyte sedimentation rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy.

Author: WeinblattM E, MaierA L, FraserP A, CoblynJ S

MTX effective for RA
MTX toxicity

Long-term treatment with methotrexate was effective in managing rheumatoid arthritis, leading to significant improvement in pain, swelling, and global assessments. The study suggests that methotrexate is a viable option for long-term rheumatoid arthritis management.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[Combination therapy in early rheumatoid arthritis: the COBRA study].

Author: BoersM, VerhoevenA C, van der LindenS

Improved rheumatoid arthritis treatment

A study of early rheumatoid arthritis (RA) found that combining sulfasalazine, prednisolone, and methotrexate for the first six months (COBRA scheme) was more effective than sulfasalazine alone over 1.5 years. The combination treatment resulted in less disease activity, less joint damage, and fewer side effects, while costing the same or less. The study recommends more aggressive treatment for early RA with a reassessment of the use of corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Dutch

12.

Combination therapy versus monotherapy for the treatment of patients with rheumatoid arthritis.

Author: CalgüneriM, PayS, CalişkanerZ, ApraşS, KirazS, ErtenliI, CobankaraV

Rheumatoid arthritis treatment
None reported

Combination therapy with disease-modifying antirheumatic drugs (DMARDs) was found to be more effective than monotherapy in treating rheumatoid arthritis (RA). The combination of methotrexate (MTX), sulfasalazine (SSZ), and hydroxychloroquine (HCQ) was the most effective treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Homeopathy and rheumatic disease.

Author: JonasW B, LindeK, RamirezG

This study highlights the limitations of current medical treatments for arthritis, which often only manage symptoms rather than prevent long-term disease progression. Surgery may still be necessary for joint problems. Many patients with arthritis seek alternative therapies, with homeopathy being one of the most popular choices globally.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

14.

Yttrium radiosynoviorthesis in the treatment of knee arthritis in rheumatoid arthritis: a systematic review.

Author: Heuft-DorenboschL L, de VetH C, van der LindenS

Limited evidence

There is no strong evidence to support the use of yttrium synovectomy in chronic knee arthritis in patients with rheumatoid arthritis compared to placebo or intra-articular steroid treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Herbal therapy for treating rheumatoid arthritis.

Author: LittleC, ParsonsT

Rheumatoid arthritis treatment

Herbal medicine (phytotherapy) is a potential treatment for rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Thermotherapy for treating rheumatoid arthritis.

Author: RobinsonV, BrosseauL, CasimiroL, JuddM, SheaB, WellsG, TugwellP

Palliative therapy
Poor quality of trials

Superficial moist heat and cryotherapy can be used as palliative therapy for rheumatoid arthritis (RA). Paraffin wax baths combined with exercises may be beneficial for short-term effects on arthritic hands. However, the quality of research on thermotherapy for RA is poor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis.

Author: FioravantiAntonella, StorriLara, Di MartinoStefania, BisognoStefania, OldaniVirginio, ScottiAurelio, MarcolongoRoberto

Effective on-demand dosing
Less GI side effects
Similar pain relief

Nimesulide-beta-cyclodextrin provides similar pain relief to naproxen in the management of OA of the hip and/or knee and is associated with fewer gastrointestinal adverse reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Thermotherapy for treating rheumatoid arthritis.

Author: RobinsonV, BrosseauL, CasimiroL, JuddM, SheaB, WellsG, TugwellP

Palliative therapy

This systematic review evaluated the effectiveness of different thermotherapy applications on objective and subjective measures of disease activity in 328 patients with rheumatoid arthritis (RA) across 7 studies. There was no significant effect of hot and ice packs applications, cryotherapy, and faradic baths on objective measures of disease activity. There was no difference in patient preference for all types of thermotherapy. Superficial moist heat and cryotherapy can be used as a palliative therapy. Paraffin wax baths combined with exercises can be recommended for beneficial short term effects for arthritic hands.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Therapeutic ultrasound for the treatment of rheumatoid arthritis.

Author: CasimiroL, BrosseauL, RobinsonV, MilneS, JuddM, WellG, TugwellP, SheaB

Increased grip strength
Increased wrist dorsal flexion
Reduced morning stiffness
Reduced painful joints
Reduced swollen joints

Ultrasound alone can be used on the hand to increase grip strength and, to a lesser extent, increase wrist dorsal flexion, decrease morning stiffness, reduce the number of swollen joints, and reduce the number of painful joints. However, these conclusions are limited by the methodological considerations such as poor quality of the trials, the low number of clinical trials, and the small sample size of the included studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Treatment of early RA in clinical practice: a comparative study of two different DMARD/corticosteroid options.

Author: SvenssonB, AhlménM, ForslindK

Effective RA treatment
Treatment failures

Patients who did not complete their first DMARD/CS treatment option had a reduced rate of individual response and remission. Treatment failures were more frequent in the sulfasalazine plus optional CS group than in the CS plus optional methotrexate treatment group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Infliximab in patients who have spondyloarthropathy: clinical efficacy, safety, and biological immunomodulation.

Author: De KeyserFilip, BaetenDominique, Van den BoschFilip, KruithofElli, MielantsHerman, VeysEric M

SpA treatment

TNF-alpha blockade is now a successful treatment for ankylosing spondylitis (AS) and other types of spondyloarthritis (SpA), establishing a new indication for this type of anticytokine therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial.

Author: GrigorCatriona, CapellHilary, StirlingAnne, McMahonAlex D, LockPeter, VallanceRamsay, KincaidWilma, PorterDuncan

Improved outcome in RA

While medications are used to treat rheumatoid arthritis (RA), many patients don’t respond well. This study aims to determine if a more intensive outpatient program, focusing on closely managing disease activity, is more effective than standard outpatient care.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

The British Rheumatoid Outcome Study Group (BROSG) randomised controlled trial to compare the effectiveness and cost-effectiveness of aggressive versus symptomatic therapy in established rheumatoid arthritis.

Author: SymmonsD, TrickerK, RobertsC, DaviesL, DawesP, ScottD L

Improved disease activity
Symptom control
Deterioration in function

A trial comparing symptomatic and aggressive treatment for established, stable rheumatoid arthritis (RA) showed no benefit of aggressive treatment. Symptomatic treatment was more cost-effective.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial.

Author: Goekoop-RuitermanY P M, de Vries-BouwstraJ K, AllaartC F, van ZebenD, KerstensP J S M, HazesJ M W, ZwindermanA H, RondayH K, HanK H, WestedtM L, GerardsA H, van GroenendaelJ H L M, LemsW F, van KrugtenM V, BreedveldF C, DijkmansB A C

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

While several treatments for rheumatoid arthritis (RA) have shown benefits, the best approach for preventing long-term joint damage and decline in function is still unclear. This study compares the clinical and radiological outcomes of four different treatment strategies with close monitoring of all patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Patients with stable long-standing rheumatoid arthritis continue to deteriorate despite intensified treatment with traditional disease modifying anti-rheumatic drugs--results of the British Rheumatoid Outcome Study Group randomized controlled clinical trial.

Author: SymmonsD, TrickerK, HarrisonM, RobertsC, DavisM, DawesP, HassellA, KnightS, MulherinD, ScottD L,

RA treatment
C-reactive protein levels
HAQ deterioration

The trial showed no additional benefit of intensified treatment with traditional disease modifying anti-rheumatic drugs (DMARDs) in patients with stable, established rheumatoid arthritis. Pending further evidence, the model of shared care with annual hospital review is as good as 4-monthly hospital review for these patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.

Author: BlakeD R, RobsonP, HoM, JubbR W, McCabeC S

Disease activity suppression
RA pain reduction
Adverse effects

A study evaluated the efficacy of a cannabis-based medicine (CBM) in treating pain due to rheumatoid arthritis. The CBM significantly improved pain, sleep quality, and disease activity compared to placebo. Further research is needed to confirm these findings and investigate the long-term effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.

Author: van der HeijdeDésirée, KlareskogLars, Rodriguez-ValverdeVicente, CodreanuCatalin, BolosiuHoratiu, Melo-GomesJose, Tornero-MolinaJesus, WajdulaJoseph, PedersenRonald, FatenejadSaeed,

Improved function
Reduced disease activity
Slowed radiographic progression

Etanercept in combination with methotrexate (MTX) was more effective than either monotherapy in reducing disease activity, slowing radiographic progression, and improving function in patients with rheumatoid arthritis (RA) over a 2-year period. No increase in toxicity was associated with combination treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

[The role of biological agents in the treatment of psoriatic arthritis, literature review].

Author: KoóEva, BrodszkyValentin, PéntekMárta, UjfalussyIlona, NagyMarianna Bettina, GulácsiLászló

Improved psoriatic arthritis treatment
Psoriatic arthritis

Understanding the role of TNF-alpha in psoriatic arthritis has led to new treatment options. TNF-alpha inhibitors (infliximab, etanercept, adalimumab), available in Hungary, offer potential for patients who haven't responded well to traditional treatments.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hungarian

29.

Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial.

Author: Goekoop-RuitermanYvonne P M, de Vries-BouwstraJeska K, AllaartCornelia F, van ZebenDerkjen, KerstensPit J S M, HazesJ Mieke W, ZwindermanAelko H, PeetersAndré J, de Jonge-BokJohanna M, MalléeConstant, de BeusWim M, de SonnavillePeter B J, EwalsJacques A P M, BreedveldFerdinand C, DijkmansBen A C

Reduced joint damage
Rheumatoid arthritis treatment
Combination therapy withdrawal

Initial combination therapies in patients with early rheumatoid arthritis may provide earlier clinical improvement and less progression of joint damage, but all treatment strategies eventually showed similar clinical improvements. This randomized controlled trial involving 508 patients found that all treatment groups, including those receiving sequential monotherapy, step-up combination therapy, and initial combination therapy, showed significant improvements in functional ability and disease activity after two years.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial.

Author: van DongenHenrike, van AkenJill, LardLeroy R, VisserKaren, RondayH Karel, HulsmansHarry M J, SpeyerIrene, WestedtMarie-Louise, PeetersAndré J, AllaartCornelia F, ToesRené E M, BreedveldFerdinand C, HuizingaTom W J

Joint damage retardation
RA diagnosis postponement

Methotrexate treatment in patients with undifferentiated arthritis postponed the diagnosis of RA and retarded radiographic joint damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

WITHDRAWN: Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee.

Author: WatsonM, BrookesS T, FaulknerA, KirwanJ

Pain relief
Insufficient evidence
Low quality studies

No substantial evidence is available related to efficacy, to distinguish between equivalent recommended doses of NSAIDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial.

Author: Goekoop-RuitermanY P M, de Vries-BouwstraJ K, AllaartC F, van ZebenD, KerstensP J S M, HazesJ M W, ZwindermanA H, RondayH K, HanK H, WestedtM L, GerardsA H, van GroenendaelJ H L M, LemsW F, van KrugtenM V, BreedveldF C, DijkmansB A C

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

While several treatments for rheumatoid arthritis (RA) have shown benefits, the best approach for preventing long-term joint damage and decline in function is still unclear. This study compares the clinical and radiological outcomes of four different treatment strategies with close monitoring of all patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

WITHDRAWN: Dynamic exercise therapy for treating rheumatoid arthritis.

Author: Van den EndeC H M, Vliet VlielandT P M, MunnekeM, HazesJ M W

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting joints and tendons, causing pain, swelling, and limited movement, eventually leading to joint damage. Exercise therapy is a crucial part of RA treatment at all stages of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Exercise therapy in juvenile idiopathic arthritis.

Author: TakkenT, van BrusselM, EngelbertR H H, Van der NetJ, KuisW, HeldersP J M

Improved aerobic capacity
Improved functional ability
Improved quality of life

There was no clinically important or statistically significant evidence that exercise therapy can improve functional ability, quality of life, aerobic capacity or pain in children with juvenile idiopathic arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Alefacept with methotrexate for treatment of psoriatic arthritis: open-label extension of a randomized, double-blind, placebo-controlled study.

Author: MeasePhilip J, ReichKristian,

Improved psoriasis and psoriatic arthritis

An additional course of alefacept in combination with methotrexate (MTX) provided further benefit for both psoriasis and psoriatic arthritis (PsA) without additional toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Infliximab and methotrexate in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of dosage regimens.

Author: ZintzarasElias, DahabrehIssa J, GiannouliStavroula, VoulgarelisMichael, MoutsopoulosHaralampos M

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Methotrexate (MTX) is the preferred medication for treating active rheumatoid arthritis (RA), due to its long-term effectiveness. However, many patients don't achieve complete remission and continue to have symptoms even at the highest tolerated dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Anakinra for rheumatoid arthritis.

Author: MertensMarty, SinghJasvinder A

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Newer treatments called "biologics" that target specific inflammation-causing molecules in rheumatoid arthritis (RA) have significantly improved treatment options. Anakinra, a medication that blocks interleukin-1, is approved by the FDA for moderate to severe RA that hasn't responded to standard treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Treatment strategies for early psoriatic arthritis.

Author: OlivieriIgnazio, D'AngeloSalvatore, PalazziCarlo, PadulaAngela

Early PsA diagnosis

Early diagnosis of psoriatic arthritis (PsA) was not a major focus until recently, as there were no medications that could significantly change the course of the disease. However, the development of drugs that block TNF-alpha has made early diagnosis of PsA much more important.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Rheumatoid arthritis.

Author: Walker-BoneKaren, FarrowSarah

Improved function
Pain relief
Infection risk
Liver damage

Several drug treatments are available for rheumatoid arthritis, including adalimumab, anakinra, antimalarial drugs, azathioprine, ciclosporin, corticosteroids, cyclophosphamide, etanercept, infliximab plus methotrexate, leflunomide, methotrexate (alone; or plus sulfasalazine plus hydroxychloroquine), oral gold, parenteral gold, penicillamine, and sulfasalazine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Use of risk stratification to target therapies in patients with recent onset arthritis; design of a prospective randomized multicenter controlled trial.

Author: ClaessenSusanne J J, HazesJohanna M W, HuismanMargriet A M, van ZebenDerkjen, LuimeJolanda J, WeelAngelique E A M

RA treatment
Over-treatment

Early and intensive treatment is key for achieving remission and preventing joint damage in people with rheumatoid arthritis. While combined treatments are most effective, doctors often start with methotrexate and short-term steroids. Intensive treatment should begin as soon as the first symptoms appear, but at this early stage, the criteria for diagnosis might not be met, which could lead to overtreatment. This study aims to determine the best initial treatment for people with early signs of persistent arthritis. To avoid both overtreatment and undertreatment, the intensity of treatment will be based on a prediction model that identifies people who are likely to develop persistent arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Therapeutic options for rheumatoid arthritis.

Author: FeelyMichael G, EricksonAlan, O'DellJames R

RA treatment

Rheumatoid arthritis (RA) is a chronic inflammatory condition that mainly affects the lining of joints. Untreated RA can lead to significant illness and a higher risk of death. New understanding of how RA works and new treatments have expanded the options for managing RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial.

Author: van VollenhovenR F, ErnestamS, GeborekP, PeterssonI F, CösterL, WaltbrandE, ZickertA, TheanderJ, ThörnerA, HellströmH, TelemanA, DackhammarC, AkreF, ForslindK, LjungL, OdingR, ChatzidionysiouA, WörnertM, BrattJ

RA treatment

New treatments for early rheumatoid arthritis are rapidly developing. This study compares the effects of adding either standard medications (sulfasalazine and hydroxychloroquine) or a TNF-inhibitor (infliximab) to methotrexate in people with early rheumatoid arthritis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial).

Author: EmeryP, DurezP, DougadosM, LegertonC W, BeckerJ-C, VratsanosG, GenantH K, PeterfyC, MitraP, OverfieldS, QiK, WesthovensR

UA/early RA treatment

Abatacept delayed progression of UA/very early RA in some patients. It inhibited radiographic and MRI progression and this effect was maintained for 6 months after treatment stopped.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

Acupuncture for peripheral joint osteoarthritis.

Author: ManheimerEric, ChengKe, LindeKlaus, LaoLixing, YooJunghee, WielandSusan, van der WindtDaniëlle Awm, BermanBrian M, BouterLex M

Improved function
Improved pain
Limited safety data
Placebo effects

Sham-controlled trials show statistically significant benefits; however, these benefits are small, do not meet our pre-defined thresholds for clinical relevance, and are probably due at least partially to placebo effects from incomplete blinding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Surgical interventions for the rheumatoid shoulder.

Author: ChristieAnne, DagfinrudHanne, Engen MatreKari, FlaattenHilde Iren, Ringen OsnesHanne, HagenKåre Birger

Improved function
Improved pain
Complications
Paucity of trials

The effects of surgical treatment for shoulder involvement in rheumatoid arthritis (RA) are largely unknown due to limited randomized controlled trials. One trial suggested that augmented subscapularis transposition may be more effective than subscapularis transposition alone in improving function and reducing pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis.

Author: MacholdKlaus P, LandewéRobert, SmolenJosef S, StammTanja A, van der HeijdeDésirée M, VerpoortKirsten N, BrickmannKerstin, Vázquez-MelladoJanitzia, KarateevDimitri E, BreedveldFerdinand C, EmeryPaul, HuizingaThomas W J

No delay in RA development
No effect on remission

Glucocorticoids did not delay remission or the development of rheumatoid arthritis (RA). Remission was rare in the first year of very early arthritis. Glucocorticoid treatment did not influence the need to start disease-modifying antirheumatic drugs (DMARDs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Evidence for treating rheumatoid arthritis to target: results of a systematic literature search.

Author: SchoelsMonika, KnevelRachel, AletahaDaniel, BijlsmaJohannes W J, BreedveldFerdinand C, BoumpasDimitrios T, BurmesterGerd, CombeBernard, CutoloMaurizio, DougadosMaxime, EmeryPaul, van der HeijdeDesirée, HuizingaTom W J, KaldenJoachim, KeystoneEdward C, KvienTore K, Martin-MolaEmilio, MontecuccoCarlomaurizio, de WitMaarten, SmolenJosef S

Better clinical outcomes

This systematic review examined the evidence for a target-oriented approach to treating rheumatoid arthritis (RA). Seven strategic clinical trials were identified, all of which showed significantly better clinical outcomes with targeted approaches compared to routine approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

48.

[Psoriatic arthritis and etanercept].

Author: PedrazJ, DaudénE

PA treatment

Psoriatic arthritis (PA) is a chronic inflammatory condition that usually develops after skin symptoms. Early diagnosis and treatment are crucial to prevent severe joint damage. Traditional treatments include NSAIDs, DMARDs like methotrexate, sulfasalazine, or gold, and leflunomide. New treatments that target specific inflammation-causing substances (biological treatments) have been developed, including anti-TNF drugs like etanercept, infliximab, and adalimumab. This review examines the main studies on etanercept for treating PA.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

49.

Cost-effectiveness of infliximab for the treatment of active and progressive psoriatic arthritis.

Author: CumminsEwen, AsseburgChristian, PunekarYogesh Suresh, ShoreEmily, MorrisJames, BriggsAndrew, FenwickElisabeth

Cost-effective treatment

Infliximab was a cost-effective treatment option for active and progressive psoriatic arthritis. In a decision analytic model, infliximab was associated with a significant reduction in Health Assessment Questionnaire score and a cost-effectiveness ratio well within the National Institute for Health and Clinical Excellence threshold.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

[Large-joint synovectomy in the era of biological therapies].

Author: CarlH-D, RechJ

RA treatment

Since the mid-1980s, there's been a significant decline in joint-related surgeries for rheumatoid arthritis (RA), including joint replacements and procedures to preserve joints. This is due to advancements in early RA management and the development of more effective medical treatments. This review examines the current trends in orthopedic surgery for RA patients and explores the role of synovectomy, a procedure to remove inflamed joint lining, in the hips, knees, and shoulders in the era of biological RA therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

51.

Herbal therapy for treating rheumatoid arthritis.

Author: CameronMelainie, GagnierJoel J, ChrubasikSigrun

RA Symptom Relief
Adverse Events

Gamma linolenic acid (GLA) from evening primrose, borage, and blackcurrant seed oils showed potential benefits in relieving rheumatoid arthritis (RA) symptoms. Tripterygium wilfordii may reduce some symptoms but can cause side effects. More research is needed on herbal therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor: a systematic review and economic evaluation.

Author: MalottkiK, BartonP, TsourapasA, UthmanA O, LiuZ, RouthK, ConnockM, JobanputraP, MooreD, Fry-SmithA, ChenY-F

Cost-effective
Improved RA

RTX and ABT are more effective than supportive care in patients with RA who have tried conventional agents and have failed to improve after trying a first tumour necrosis factor (TNF) inhibitor. At 6 months significantly more patients treated with RTX achieved ACR 20 [relative risk (RR) = 2.85, 95% confidence interval (CI) 2.08 to 3.91] and ACR70 (RR = 12.14, 95% CI 2.96 to 49.86) compared with those treated with the placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Greater remission rates in patients with early versus long-standing disease in biologic-naive rheumatoid arthritis patients treated with abatacept: a post hoc analysis of randomized clinical trial data.

Author: YaziciY, Moniz ReedD, KlemC, RosenblattL, WuG, KremerJ M

RA treatment

The goal of rheumatoid arthritis (RA) treatment is to achieve remission in as many patients as possible. This study compares the rates of remission and treatment outcomes in patients with early-onset RA (less than 10 years) and those with long-standing RA (10 years or more) who were treated with abatacept, a biologic drug, after not responding to methotrexate (MTX).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

[Consensus on the Use of Rituximab in Rheumatoid Arthritis. A document with evidence-based recommendations. Grupo de Expertos en Rituximab. ].

Author: Martín MolaEmilio, HernándezBlanca, García-AriasMiriam, Alvaro-GraciaJosé María, BalsaAlejandro, ReinoJuan Gómez, Marenco de la FuenteJosé L, Martínez-TaboadaVíctor, IvorraJosé Andrés Román, SanmartíRaimon,

RA treatment

Recommendations for the use of rituximab in treating rheumatoid arthritis (RA) were established based on expert opinions and systematic reviews. While efficacy recommendations have a high degree of evidence, safety recommendations have a lower degree of evidence.

Consensus Development ConferenceA conference organized by the National Institutes of Health (NIH) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

55.

Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondylarthritis) and gastrointestinal or liver comorbidity.

Author: RadnerHelga, RamiroSofia, BuchbinderRachelle, LandewéRobert B M, van der HeijdeDésirée, AletahaDaniel

Pain management for arthritis
Gastrointestinal risks
Liver risks

Persistent pain due to structural damage is common in people with inflammatory arthritis despite optimal disease-modifying treatment. This review emphasizes the importance of considering comorbidities when choosing pain management strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial.

Author: BakkerMarije F, JacobsJohannes W G, WelsingPaco M J, VerstappenSuzanne M M, TekstraJanneke, TonEvelien, GeurtsMonique A W, van der WerfJacobine H, van Albada-KuipersGrietje A, Jahangier-de VeenZalima N, van der VeenMaaike J, VerhoefCatharina M, LafeberFloris P J G, BijlsmaJohannes W J,

Improved remission
Reduced disability
Reduced disease activity
Reduced joint damage
Reduced need for additional drugs
Adverse events

Adding low-dose prednisone to a methotrexate (MTX)-based treatment strategy for tight control in early rheumatoid arthritis (RA) improves patient outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor.

Author: Navarro-MillánIris, SinghJasvinder A, CurtisJeffrey R

Treatment of rheumatoid arthritis

Tocilizumab (TCZ) is a new medication for rheumatoid arthritis (RA) patients who have not responded well to other treatments, like anti-TNF therapies. It blocks a specific inflammatory protein in the body.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial.

Author: MorelandLarry W, O'DellJames R, PaulusHarold E, CurtisJeffrey R, BathonJoan M, St ClairE William, BridgesS Louis, ZhangJie, McVieTheresa, HowardGeorge, van der HeijdeDésirée, CofieldStacey S,

Treatment of early RA

This study compares two approaches to treating early rheumatoid arthritis (RA): 1. **Intensive treatment:** All patients receive a combination of medications from the start. 2. **Step-up approach:** Patients initially receive a single medication (methotrexate, MTX). If their disease activity remains high after 24 weeks, they are switched to combination therapy. The study also investigates whether combining MTX with etanercept (a type of biologic drug) is more effective than combining MTX with sulfasalazine and hydroxychloroquine (two commonly used medications).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

Bioequivalence study of a novel orodispersible tablet of meloxicam in a porous matrix after single-dose administration in healthy volunteers.

Author: RadicioniMilko, ConnollySandra, StroppoloFederico, GranataGabriele, LopreteLuca, LeurattiChiara

Bioequivalent formulations

The orodispersible tablet (ODT) and tablet formulations of meloxicam were bioequivalent in the fasting healthy volunteers enrolled.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

A non-inferiority trial of an attenuated combination strategy ('COBRA-light') compared to the original COBRA strategy: clinical results after 26 weeks.

Author: den UylDebby, ter WeeMarieke, BoersMaarten, KerstensPit, VoskuylAlexandre, NurmohamedMike, RatermanHennie, van SchaardenburgDirkjan, van DillenNancy, DijkmansBen, LemsWillem

RA treatment
Radiological progression suppression
Side effects

COBRA therapy is an effective treatment for rheumatoid arthritis (RA) but is not often used because of concerns about side effects. This study will investigate the effectiveness of a less intensive version of COBRA therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Drug therapy in undifferentiated arthritis: a systematic literature review.

Author: Wevers-de BoerK V C, HeimansL, HuizingaT W J, AllaartC F

Reduced radiological progression
Suppressed disease activity
Long-term benefit unclear

Undifferentiated arthritis (UA) is a type of arthritis that cannot be definitively diagnosed. This study reviewed the literature on the use of various drug therapies for UA. The study found that methotrexate, abatacept, and intramuscular corticosteroids were more effective than placebo at suppressing disease activity. The long-term benefits of early treatment remain unclear, and more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Therapies for active rheumatoid arthritis after methotrexate failure.

Author: O'DellJames R, MikulsTed R, TaylorThomas H, AhluwaliaVandana, BrophyMary, WarrenStuart R, LewRobert A, CannellaAmy C, KunkelGary, PhibbsCiaran S, AnisAslam H, LeathermanSarah, KeystoneEdward,

RA treatment

There are limited studies that directly compare conventional treatments (combinations of medications) with biologic drugs in rheumatoid arthritis (RA) patients whose disease isn't adequately controlled by methotrexate, a common situation in managing RA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, American Recovery and Reinvestment ActResearch and economic activity support funds provided under the American Recovery and Reinvestment Act of 2009.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

63.

Biological vs. conventional combination treatment and work loss in early rheumatoid arthritis: a randomized trial.

Author: ErikssonJonas K, NeoviusMartin, BrattJohan, PeterssonIngemar F, van VollenhovenRonald F, GeborekPierre, ErnestamSofia

RA treatment

New medications that block tumor necrosis factor (TNF) have improved treatment for rheumatoid arthritis (RA) but are expensive. These medications have shown better long-term results for joint damage compared to conventional medications after 2 years of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

64.

The mid-term outcome of total ankle arthroplasty and ankle fusion in rheumatoid arthritis: a systematic review.

Author: van HeiningenJacqueline, Vliet VlielandThea P M, van der HeideHuub J L

Clinical improvement
Improved ankle function
Implant failure
Non-union

A review of 17 observational studies on the effectiveness of arthroplasty or arthrodesis of the ankle in rheumatoid arthritis showed that both interventions demonstrate clinical improvement. While neither procedure appears to be superior to the other, the methodological quality of the studies was low, necessitating further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Safety of anti-tumor necrosis factor agents in psoriatic arthritis - an update.

Author: PalazziCarlo, D'AngeloSalvatore, LeccesePietro, PadulaAngela, OlivieriIgnazio

PsA treatment

Medications that block tumor necrosis factor (TNF) have revolutionized treatment for rheumatoid arthritis and spondyloarthritides (SpAs). For psoriatic arthritis (PsA), these medications are much more effective than conventional treatments in addressing all aspects of the disease, including spine, joints, tendons, fingers, and skin lesions. Understanding their safety is crucial for doctors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Clinical, functional, and radiographic implications of time to treatment response in patients with early rheumatoid arthritis: a posthoc analysis of the PREMIER study.

Author: KeystoneEdward C, HaraouiBoulos, GuéretteBenoît, MozaffarianNeelufar, LiuShufang, KavanaughArthur

Improved function
Reduced inflammation

This analysis examines the long-term clinical, functional, and radiographic outcomes associated with delayed responses to methotrexate (MTX) monotherapy or the combination of adalimumab (ADA) + MTX in patients with rheumatoid arthritis (RA).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Rituximab for rheumatoid arthrits treatment: a systematic review.

Author: de LemosLívia Lovato Pires, CostaJuliana de Oliveira, MachadoMarina Amaral de Ávila, AlmeidaAlessandra Maciel, BarbosaMariana Michel, KakehasiAdriana Maria, de AraújoVânia Eloísa, Guerra JúniorAugusto Afonso, AcurcioFrancisco de Assis

RA treatment

Rheumatoid arthritis (RA) is a chronic condition that causes inflammation in the joints, leading to disability. While several medications have proven effective, some patients don't respond well. Rituximab, a type of antibody medication, is used for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Failure in longterm treatment is rare in actively treated patients with rheumatoid arthritis, but may be predicted by high health assessment score at baseline and by residual disease activity at 3 and 6 months: the 5-year followup results of the randomized clinical NEO-RACo trial.

Author: RantalaihoVappu, KautiainenHannu, JärvenpääSalme, KorpelaMarkku, MalmiTimo, HannonenPekka, Kaipiainen-SeppänenOili, Yli-KerttulaTimo, MöttönenTimo, MustilaAnu, KarjalainenAnna, PaimelaLeena, UutelaToini, Leirisalo-RepoMarjatta,

RA treatment

While new treatments for rheumatoid arthritis (RA) have improved outcomes for most patients, some people still don't achieve remission, experience joint damage, and have limitations in function. This study aims to identify the factors that contribute to poor outcomes even with aggressive treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

69.

Randomised controlled trial of tumour necrosis factor inhibitors against combination intensive therapy with conventional disease-modifying antirheumatic drugs in established rheumatoid arthritis: the TACIT trial and associated systematic reviews.

Author: ScottDavid L, IbrahimFowzia, FarewellVern, O'KeeffeAidan G, MaMargaret, WalkerDavid, HeslinMargaret, PatelAnita, KingsleyGabrielle

Equivalent clinical benefits
Lower costs
Limited remission
Serious adverse events

Combination disease-modifying antirheumatic drugs (cDMARDs) were found to be as effective as tumor necrosis factor inhibitors (TNFis) in treating rheumatoid arthritis (RA), but at a lower cost. Patients who initially received cDMARDs experienced greater reductions in HAQ scores and increases in EQ-5D scores at 12 months. Both cDMARDs and TNFis resulted in similar rates of DAS28 remission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial.

Author: HenriksenMarius, ChristensenRobin, KlokkerLouise, BartholdyCecilie, BandakElisabeth, EllegaardKaren, BoesenMikael P, RiisRobert G Coumine, BartelsElse M, BliddalHenning

No additional benefit

An intra-articular injection of corticosteroid before exercise did not provide additional benefit for patients with painful osteoarthritis (OA) of the knee. Further research is needed to identify optimal and synergistic combinations of conservative treatments for OA of the knee.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial.

Author: KingsburySarah R, TharmanathanPuvan, ArdenNigel K, BatleyMichael, BirrellFraser, CocksKim, DohertyMichael, EdwardsChris J, GarroodToby, GraingerAndrew J, GreenMichael, HewittCatherine, HughesRod, MootsRobert, O'NeillTerence W, RoddyEdward, ScottDavid L, WattFiona E, TorgersonDavid J, ConaghanPhilip G

OA treatment

Osteoarthritis (OA) is a major cause of disability with limited treatment options. OA pain is often linked to inflammation of the joint lining (synovitis). Methotrexate (MTX) is a safe and effective treatment for synovitis in other inflammatory joint diseases like rheumatoid arthritis. This study proposes that MTX could be a practical and safe treatment for reducing synovitis and pain in patients with knee OA.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

72.

Balneotherapy (or spa therapy) for rheumatoid arthritis. An abridged version of Cochrane Systematic Review.

Author: VerhagenA P, Bierma-ZeinstraS M, BoersM, CardosoJ R, LambeckJ, De BieR, De VetH C

Ineffective treatment

This systematic review evaluated the benefits and harms of balneotherapy in patients with rheumatoid arthritis (RA). The overall evidence was insufficient to show that balneotherapy was more effective than no treatment, or one type of bath was more effective than another.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

Are All Biologics the Same? Optimal Treatment Strategies for Patients With Early Rheumatoid Arthritis: Systematic Review and Indirect Pairwise Meta-Analysis.

Author: AlbertDaniel A

RA treatment

A meta-analysis of six randomized controlled trials found that biologic agents in conjunction with a DMARD performed similarly in DMARD-naive RA patients. However, etanercept 50 mg appeared superior to adalimumab 40 mg, golimumab 50 mg, and infliximab 3 and 6 mg/kg at ACR20. Rituximab 1000 mg and etanercept 50 mg appeared superior to golimumab 100 mg at ACR50.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Optimisation of a treat-to-target approach in rheumatoid arthritis: strategies for the 3-month time point.

Author: AletahaDaniel, AlastiFarideh, SmolenJosef S

Improved rheumatoid arthritis

The 3-month time point is a critical decision point for rheumatoid arthritis (RA) treatment. Not achieving minor responses at 3 months makes reaching the treatment target at 6 months highly unlikely, while reaching major responses is highly predictive of reaching the treatment target.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

75.

Trial-based cost-effectiveness of abatacept for rheumatoid arthritis patients in Italy.

Author: GaultneyJ, BenucciM, IannazzoS, NappiC, SionK, SabaterF J

Lower total costs

A cost-consequence analysis assessing the cost-effectiveness of abatacept relative to adalimumab for rheumatoid arthritis (RA) in Italy found that abatacept had lower total costs and health gains based on more stringent efficacy criteria. The health economic value of abatacept compared with adalimumab depended on the choice of health outcome.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

77.

AMSSM Scientific Statement Concerning Viscosupplementation Injections for Knee Osteoarthritis: Importance for Individual Patient Outcomes.

Author: TrojianThomas H, ConcoffAndrew L, JoySusan M, HatzenbuehlerJohn R, SaulsberryWhitney J, ColemanCraig I

Knee OA treatment

Osteoarthritis (OA) of the knee causes pain and limited mobility. While treatments include injections of hyaluronic acid (HA), steroids (IAS), and placebo (IAP), this review examines the effectiveness of these treatments based on how many patients achieve a meaningful improvement in function, as defined by specific criteria, rather than just comparing average changes between groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

78.

Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study).

Author: HeimansLotte, AkdemirGülşah, BoerKirsten V C Wevers-de, Goekoop-RuitermanYvonne P, MolenaarEsmeralda T, van GroenendaelJohannes H L M, PeetersAndreas J, Steup-BeekmanGerda M, LardLeroy R, de SonnavillePeter B J, GrilletBernard A M, HuizingaTom W J, AllaartCornelia F

Damage prevention
Disease activity suppression
Drug-free remission
Remission

After 2 years remission-steered treatment in early RA and UA patients, DAS-remission and DFR percentages were relatively low. Patients who achieved early remission more often achieved (drug-free) remission after 2 years than patients who needed additional treatment steps in the randomization arms, and more UA than RA patients achieved DFR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Long-Term Outcomes of Patients With Recent-Onset Rheumatoid Arthritis After 10 Years of Tight Controlled Treatment: A Randomized Trial.

Author: MarkusseIris M, AkdemirGülsah, DirvenLinda, Goekoop-RuitermanYvonne P M, van GroenendaelJohannes H L M, HanK Huub, MolenaarT H Esmeralda, Le CessieSaskia, LemsWillem F, van der LubbePeter A H M, KerstensPit J S M, PeetersAndré J, RondayH Karel, de SonnavillePeter B J, SpeyerIrene, StijnenTheo, Ten WoldeSaskia, HuizingaTom W J, AllaartCornelia F

Drug-free remission
Functional improvement
Normalized survival
Radiographic damage prevention
Dropout rate

Initial combination therapy in patients with early rheumatoid arthritis resulted in faster clinical improvement, and targeted treatment determined long-term outcomes, with a 53% remission rate and a 14% drug-free remission rate after 10 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

80.

The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation.

Author: ShepherdJonathan, CooperKeith, HarrisPetra, PicotJoanna, RoseMicah

JIA treatment

Juvenile idiopathic arthritis (JIA) is a condition that causes joint pain, swelling, and limited movement in children. Treatment often involves medications called disease-modifying antirheumatic drugs (DMARDs) like methotrexate. Newer medications, called biologic DMARDs, are now commonly used when appropriate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Psoriasis, psoriatic arthritis, and rheumatoid arthritis: Is all inflammation the same?

Author: CoatesLaura C, FitzGeraldOliver, HelliwellPhilip S, PaulCarle

Psoriasis treatment
Psoriatic arthritis treatment
RA treatment

This review examines the causes, associated conditions, and treatment options for psoriasis, psoriatic arthritis, and rheumatoid arthritis. The goal is to better understand the similarities and differences in how these diseases are managed and to identify new targets for personalized treatments that improve outcomes and reduce side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial.

Author: LiRu, ZhaoJin-Xia, SuYin, HeJing, ChenLi-Na, GuFei, ZhaoCheng, DengXue-Rong, ZhouWei, HaoYan-Jie, XueYu, LiuHua-Xiang, ZhaoYi, ZouQing-Hua, LiuXiang-Yuan, ZhuPing, SunLing-Yun, ZhangZhuo-Li, ZouHe-Jian, LiXing-Fu, LiuYi, FangYong-Fei, KeystoneEdward, McInnesIain B, LiZhan-Guo

RA remission
Reduced RA flares

Intensive treatment with disease-modifying antirheumatic drugs can help patients with rheumatoid arthritis achieve remission. Patients who achieve remission have lower relapse rates. Leflunomide is a good option for maintenance treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

83.

Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis.

Author: HazlewoodGlen S, BarnabeCheryl, TomlinsonGeorge, MarshallDeborah, DevoeDaniel J A, BombardierClaire

Improved disease activity
Reduced radiographic progression
Increased adverse events

Methotrexate combined with other DMARDs, biologics, or tofacitinib is more effective than methotrexate alone in treating rheumatoid arthritis (RA), especially in patients who have not responded to methotrexate previously. The combination therapies were found to be well-tolerated and associated with a higher rate of ACR50 response, a measure of disease activity, compared to methotrexate alone. However, the combination therapies did not significantly improve radiographic progression. While some combinations were associated with a higher rate of adverse events, others, like triple therapy, were associated with fewer withdrawals due to adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Are gene polymorphisms related to treatment outcomes of methotrexate in patients with rheumatoid arthritis? A systematic review and meta-analysis.

Author: ChenYuehong, ZouKun, SunJianhong, YangYuan, LiuGang

Improved RA response to MTX
MTX adverse events

This study investigated the correlations between gene polymorphisms and efficacy and/or toxicity in methotrexate (MTX)-treated rheumatoid arthritis (RA) patients. The study found that polymorphisms in AMPD1 34C>T and ATIC T675C predict responsiveness. The absence of TYMS 1494 del6 and FPGS rs10106 and presence of MTHFR C677T predict adverse events in RA patients treated with MTX.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Celecoxib for rheumatoid arthritis.

Author: FidahicMahir, Jelicic KadicAntonia, RadicMislav, PuljakLivia

RA treatment

Rheumatoid arthritis is a chronic autoimmune disorder that causes inflammation in joints and tendons. There is no cure, and treatment focuses on managing pain, stiffness, and mobility to achieve remission and improve function. Celecoxib is a medication used to treat rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.

Author: HoxhaMalvina

RA treatment

Rheumatoid arthritis is a condition where the body's immune system attacks the joints, causing inflammation, pain, and damage. While steroids and NSAIDs can reduce pain and inflammation, they don't stop the damage to cartilage and bone. Treatment options include disease-modifying medications, steroids, NSAIDs, and biological agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

The clinical effectiveness and cost-effectiveness of treat-to-target strategies in rheumatoid arthritis: a systematic review and cost-effectiveness analysis.

Author: WailooAllan, HockEmma S, StevensonMatt, Martyn-St JamesMarrissa, RawdinAndrew, SimpsonEmma, WongRuth, DracupNaila, ScottDavid L, YoungAdam

Improved RA treatment

"Treat to target" (TTT) is an approach for managing rheumatoid arthritis (RA) that involves setting clear goals for treatment, such as remission or low disease activity. This approach often includes regular checkups and rapid adjustments to medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial): study protocol for a randomised controlled trial.

Author: MartinNaomi H, IbrahimFowzia, TomBrian, GallowayJames, WailooAllan, ToshJonathan, LemppHeidi, ProtheroLouise, GeorgopoulouSofia, SturtJackie, ScottDavid L,

RA treatment

Untreated rheumatoid arthritis (RA) can worsen over time, causing disability and impacting quality of life. While aggressive treatment has been shown to be effective in early and established cases, there are no standard guidelines for people with RA who have moderate disease activity. This study aims to determine if intensive treatment for these patients leads to more remissions after 12 months. The study will also examine the impact on disability, quality of life, and the cost-effectiveness of this approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

90.

Is secukinumab effective for psoriatic arthritis with insufficient response to initial treatment?

Author: Venegas-IribarrenSoledad, Andino-NavarreteRomina

Psoriatic arthritis treatment

Psoriatic arthritis is a type of arthritis with no known cause. Biological therapies, especially for severe cases, have become important for treatment. While secukinumab is a potential biological treatment option, its effectiveness and safety, especially given its high cost, are not completely understood.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Spanish

91.

Medical Care Costs Associated With Rheumatoid Arthritis in the US: A Systematic Literature Review and Meta-Analysis.

Author: HreskoAndrew, LinTzu-Chieh, SolomonDaniel H

RA treatment

Rheumatoid arthritis (RA) is a serious and costly condition with no cure. Treatment options have expanded in recent years, including the use of biologic disease-modifying antirheumatic drugs (bDMARDs). This review examines the medical costs associated with different RA treatments, as there hasn't been a comprehensive review since the introduction of these new medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Cost and Cost Effectiveness of Treatments for Psoriatic Arthritis: A Systematic Literature Review.

Author: D'AngiolellaLucia Sara, CortesiPaolo Angelo, LafranconiAlessandra, MicaleMariangela, ManganoSveva, CesanaGiancarlo, MantovaniLorenzo Giovanni

New treatments
Psoriatic arthritis treatment
Cost optimization

Psoriatic arthritis is a chronic inflammatory condition affecting joints and skin. It can lead to joint damage and is associated with other health problems. New treatments have emerged in recent years, but it's important to compare their costs and benefits to make the best use of available resources.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

93.

Do out-of-pocket costs affect medication adherence in adults with rheumatoid arthritis? A systematic review.

Author: HeidariParvaneh, CrossWendy, CrawfordKimberley

Biologic agents
RA treatment
Medication cost

People with chronic illnesses often struggle to manage their medications long-term, leading to non-adherence. While biologic medications have been a significant advancement for rheumatoid arthritis (RA), their high cost may limit their use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Is ustekinumab effective for psoriatic arthritis with insufficient response to initial treatment?

Author: Venegas-IribarrenSoledad, Andino-NavarreteRomina

Clinical improvement
Reduced adverse effects

Ustekinumab was found to lead to clinical improvement in psoriatic arthritis and is probably not associated with severe adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Spanish

95.

Cost Effectiveness of Intra-Articular Hyaluronic Acid and Disease-Modifying Drugs in Knee Osteoarthritis.

Author: SalmonJean-Hugues, RatAnne-Christine, Charlot-LambrechtIsabelle, EschardJean-Paul, JollyDamien, FautrelBruno

Symptomatic efficacy for knee OA
Heterogeneous cost-effectiveness estimates
No efficacy for disease modification

The cost-effectiveness of disease-modifying osteoarthritis drugs and intra-articular hyaluronic acid for knee osteoarthritis is uncertain, with incremental cost-effectiveness ratios ranging from cost savings to very high values.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Update of French society for rheumatology recommendations for managing rheumatoid arthritis.

Author: DaienClaire, HuaCharlotte, Gaujoux-VialaCécile, CantagrelAlain, DubremetzMadeleine, DougadosMaxime, FautrelBruno, MarietteXavier, NayralNathalie, RichezChristophe, SarauxAlain, ThibaudGérard, WendlingDaniel, GossecLaure, CombeBernard

DMARD therapy
RA treatment
Tight disease control

New guidelines for managing rheumatoid arthritis (RA) emphasize the importance of shared decision-making between patients and doctors and a comprehensive approach that includes medication and non-medication treatments. Treatment should start as early as possible and aim to achieve remission, with methotrexate being the preferred initial medication. Treatment should be adjusted based on the patient's response and tolerance. While corticosteroids may be used in the short term, they should be gradually reduced once remission is achieved. Regular checkups for other health problems are also recommended.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Intensive therapy and remissions in rheumatoid arthritis: a systematic review.

Author: HughesCatherine D, ScottDavid L, IbrahimFowzia,

RA remission

A meta-analysis of 53 studies found that intensive treatment with combination DMARDs, biologics, or JAK inhibitors increased the frequency of remission in patients with rheumatoid arthritis compared to control non-intensive strategies. This benefit was observed in both early and established rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews.

Author: ArcherRachel, HockEmma, HamiltonJean, StevensJohn, EssatMunira, PokuEdith, ClowesMark, PandorAbdullah, StevensonMatt

Prognosis assessment
RA treatment

Rheumatoid arthritis (RA) is a chronic condition that significantly impacts quality of life and is costly to manage. It's unclear which tests and assessments best predict how RA will progress and which patients will respond well to different medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study.

Author: HuangYong, LiuXiaolu, XuXinliang, LiuJunbin

CS
HA
IA therapies
KOA treatment
PRP

Knee osteoarthritis (KOA) is a painful condition with no cure. While there are various treatments for KOA, injections into the joint (intra-articular therapies) are increasingly used, including platelet-rich plasma (PRP), hyaluronic acid (HA), and corticosteroids (CS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

100.

The effects of TNF-alpha inhibitor therapy on the incidence of infection in JIA children: a meta-analysis.

Author: NagyArnold, MátraiPéter, HegyiPéter, AlizadehHussain, BajorJudit, CzopfLászló, GyöngyiZoltán, KissZoltán, MártaKatalin, SimonMária, SzilágyiÁgnes Lilla, VeresGábor, MosdósiBernadett

JIA treatment
JIA diagnosis

Juvenile Idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The diagnosis is based on symptoms of arthritis, excluding other diseases. Biologic agents are increasingly used alongside disease-modifying anti-rheumatic drugs (DMARD) in JIA treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

101.

Terpenes as possible drugs for the mitigation of arthritic symptoms - A systematic review.

Author: CarvalhoAlexandra M S, HeimfarthLuana, SantosKlécia A, GuimarãesAdriana G, PicotLaurent, AlmeidaJackson R G S, QuintansJullyana S S, Quintans-JúniorLucindo J

Alternative treatments
Arthritis treatment

Arthritis is a condition that causes joint inflammation, pain, and disability. While there are treatments, they can have side effects, and many people stop taking their medications. As a result, new treatments are being sought.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

Network meta-analysis of tofacitinib versus biologic treatments in moderate-to-severe rheumatoid arthritis patients.

Author: Camean-CastilloManuel, Gimeno-BallesterVicente, Rios-SanchezEsmeralda, Fenix-CaballeroSilvia, Vázquez-RealMiguel, Alegre-Del ReyEmilio

RA treatment
Tofacitinib

This study compared the effectiveness of different treatments for rheumatoid arthritis (RA), including biological DMARDs (disease-modifying antirheumatic drugs) used alone or with methotrexate, and tofacitinib, an oral medication that blocks certain proteins involved in inflammation. The study aims to determine which treatment options are most effective for patients with RA who don't respond well to traditional DMARDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

103.

Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial.

Author: HuangRun-Yue, PanHu-Dan, WuJia-Qi, ZhouHua, LiZhan-Guo, QiuPing, ZhouYing-Yan, ChenXiu-Min, XieZhi-Xin, XiaoYao, HuangQing-Chun, LiuLiang

MTX combination therapy
RA treatment

Combining different conventional medications to treat rheumatoid arthritis (RA) is often effective but can have significant side effects. This study emphasizes the need for a safer and more effective alternative to expensive biological treatments, focusing on methotrexate (MTX) combination therapy. The aim is to find a combination of medications that provides a high level of effectiveness with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

104.

Patient Preferences for Disease-modifying Antirheumatic Drug Treatment in Rheumatoid Arthritis: A Systematic Review.

Author: DurandCaylib, EldomaMaysoon, MarshallDeborah A, BansbackNick, HazlewoodGlen S

Disease improvement
Side effects

Patients with rheumatoid arthritis (RA) generally place a high value on treatment benefits over other treatment attributes, including serious or minor side effects, cost, or route of administration. However, patient preferences vary, highlighting the need for individualized treatment choices.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

105.

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial.

Author: GenoveseMark C, KalunianKenneth, GottenbergJacques-Eric, MozaffarianNeelufar, BartokBeatrix, MatzkiesFranziska, GaoJie, GuoYing, TassetChantal, SundyJohn S, de VlamKurt, WalkerDavid, TakeuchiTsutomu

RA response
Herpes zoster
Retinal vein occlusion

Filgotinib, a JAK1/JAK3 inhibitor, was found to be significantly more effective than placebo in achieving clinical response at week 12 in patients with active rheumatoid arthritis (RA) who had an inadequate response or intolerance to 1 or more biologic disease-modifying antirheumatic drugs (bDMARDs).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

106.

Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics Alone for Early Rheumatoid Arthritis in Adults: a Systematic Review and Network Meta-analysis.

Author: DonahueKatrina E, SchulmanElizabeth R, GartlehnerGerald, JonasBeth L, Coker-SchwimmerEmmanuel, PatelSheila V, WeberRachel Palmieri, BannCarla M, ViswanathanMeera

Improved disease control
Improved functional capacity
Improved remission

Combination therapy with tumor necrosis factor (TNF) or non-TNF biologics plus methotrexate (MTX) was more effective than MTX monotherapy in reducing disease activity and improving remission in patients with early rheumatoid arthritis (RA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

107.

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era.

Author: HsiehPing-Hsuan, WuOlivia, GeueClaudia, McIntoshEmma, McInnesIain B, SiebertStefan

Improved clinical outcomes
Reduced hospitalizations
Reduced work disability

This systematic review mapped the existing evidence concerning cost of illness of rheumatoid arthritis (RA) in the biologic era. The study found that drug costs comprised the main component of direct costs, while indirect costs, primarily associated with absenteeism and work disability, accounted for a significant proportion of total costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

Prognostic factors of good response to DMARDs in psoriatic arthritis: a narrative review.

Author: MekhailChristine, ChoukMickaël, PratiClément, WendlingDaniel, VerhoevenFrank

A review of literature on psoriatic arthritis (PsA) treatment suggests that dactylitis and axial involvement are associated with poor response to methotrexate, leflunomide is more effective in polyarticular involvement, TNF inhibitors are preferred for young men with elevated CRP, and apremilast and ustekinumab are more effective in mono and oligo articular disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Safety of repository corticotropin injection as an adjunctive therapy for the treatment of rheumatoid arthritis.

Author: FleischmannRoy, FurstDaniel E

Improved RA treatment

Disease-modifying antirheumatic drugs (DMARDs) are very helpful for rheumatoid arthritis (RA) patients, but some still don't achieve optimal results. This study focuses on the use of repository corticotropin injection (RCI) as a short-term treatment option for those with ongoing RA symptoms, even after starting DMARDs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

110.

[Is osteoarthritis an inflammatory disease after all?; prednisolone effective in osteoarthritis of the hand].

Author: LemsWillem F

OA pain relief
Prednisolone side effects

A short-term study demonstrated that prednisolone effectively reduces pain in patients with inflammatory osteoarthritis of the hand. This finding highlights the potential of anti-inflammatory drugs in managing this condition, although long-term safety concerns remain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Dutch

111.

Corticosteroids: Review of the History, the Effectiveness, and Adverse Effects in the Treatment of Joint Pain.

Author: StoneShane, MalangaGerard A, CapellaTeresa

Improved function
Reduced pain
Cartilage toxicity
Increased blood glucose
Increased infections
Reduced immune function

This narrative review summarized the research on corticosteroids for joint pain from its initial discovery to the present day. The study found that corticosteroids provide moderate short-term benefit for reducing pain and improving function, but these benefits generally last several weeks without long-term effectiveness. The study also highlighted potential adverse effects including toxicity to articular cartilage and numerous systemic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

112.

Efficacy of intra-articular corticosteroid injections in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Author: NajmAurélie, AlunnoAlessia, GwinnuttJames M, WeillCatherine, BerenbaumFrancis

Function improvement
Pain reduction

IA GC injections reduced pain and improved function early after administration compared to placebo. Other interventions seem to be more efficient in the long term, but this effect was largely driven by single studies with large effect sizes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

Intra-articular therapy with methotrexate or tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic review.

Author: SullivanMegan M, PhamMichael M, MarksLisa A, AslamFawad

IA DMARDs
RA treatment

Treating a single joint that's still inflamed in people who have otherwise well-controlled rheumatoid arthritis (RA) can be difficult. While steroid injections directly into the joint are often used, there's debate about whether other medications for RA, like DMARDs and biologics, can be used if injections don't work.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

114.

Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review.

Author: GandhiGopalsamy Rajiv, JothiGnanasekaran, MohanaThiruchenduran, VasconcelosAlan Bruno Silva, MontalvãoMonalisa Martins, HariharanGovindasamy, SridharanGurunagarajan, KumarPerumal Madan, GurgelRicardo Querioz, LiHua-Bin, ZhangJinming, GanRen-You

Medicinal plants
Natural alternative
Potential for RA treatment
RA treatment
Needs further research
Potential for interactions
Side effects
Unclear effectiveness

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can severely affect movement and quality of life. Current treatments focus on suppressing inflammation in the joints, but often have side effects. Herbal remedies are being explored as potential alternative treatments for RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis.

Author: JiangXiaofan, ZengJin, ChenFang, LiJuane

RA treatment

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints. Methotrexate (MTX) is a common treatment for RA. This study will examine research to determine how well MTX works in treating RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

116.

Undifferentiated arthritis: a changing population who did not benefit from enhanced disease-modifying anti-rheumatic drug strategies-results from a 25 year longitudinal inception cohort.

Author: VerstappenMarloes, MatthijssenXanthe M E, van der Helm-van MilAnnette H M

Improved outcomes

International guidelines recommend early initiation of disease-modifying antirheumatic drugs (DMARDs) in early arthritis, but there are no placebo-controlled trials on DMARD efficacy in contemporary undifferentiated arthritis (UA). This study explores whether enhanced treatment strategies have improved outcomes in UA patients, considering the evolving definition of UA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

117.

Arthroscopic Synovectomy of the Wrist in Patients With Rheumatoid Arthritis: A Systematic Review of the Current Literature.

Author: d'AillyPhilip N, MuldersMarjolein A M, BisoendialRadjesh J, KuijperT Martijn, CoertJ Henk, SchepNiels W L

RA pain relief
Wrist function improvement

This systematic review evaluated functional outcomes and pain following arthroscopic synovectomy of the wrist in rheumatoid arthritis (RA) patients. The procedure showed promising results in improving pain and wrist function, with low complication rates. However, more research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Randomized Clinical Trials on the Efficacy and Safety of Tocilizumab in Subjects with Rheumatoid Arthritis: A Systematic Review.

Author: SadeqAdel, ElnourAsim Ahmed, RamadanAzza, KidirIsraa Yousif, DonJudit, Al AmoodiAbdulla, Al MazroueiNadia, BarakaMohamed A, FarahFarah Hamad, AlkaabiMaisoun

RA activity
TCZ
Lipid profiles

Tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA), reducing disease activity and improving disability. TCZ may be associated with increased cholesterol levels but does not appear to increase the risk of serious adverse events.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

119.

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.

Author: OnelKaren B, HortonDaniel B, LovellDaniel J, ShenoiSusan, CuelloCarlos A, Angeles-HanSheila T, BeckerMara L, CronRandy Q, FeldmanBrian M, FergusonPolly J, GewanterHarry, GuzmanJaime, KimuraYukiko, LeeTzielan, MurphyKatherine, NigrovicPeter A, OmbrelloMichael J, RabinovichC Egla, TesherMelissa, TwiltMarinka, Klein-GitelmanMarisa, Barbar-SmileyFatima, CooperAshley M, EdelheitBarbara, Gillispie-TaylorMiriah, HaysKimberly, MannionMelissa L, PetersonRosemary, FlanaganElaine, SaadNadine, SullivanNancy, SzymanskiAnn Marie, TrachtmanRebecca, TurgunbaevMarat, VeigaKeila, TurnerAmy S, RestonJames T

Improved quality of life
Shared decision-making

This clinical practice guideline provides recommendations for the management of juvenile idiopathic arthritis (JIA), including nonpharmacologic therapies, medication monitoring, immunizations, and imaging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.

Author: OnelKaren B, HortonDaniel B, LovellDaniel J, ShenoiSusan, CuelloCarlos A, Angeles-HanSheila T, BeckerMara L, CronRandy Q, FeldmanBrian M, FergusonPolly J, GewanterHarry, GuzmanJaime, KimuraYukiko, LeeTzielan, MurphyKatherine, NigrovicPeter A, OmbrelloMichael J, RabinovichC Egla, TesherMelissa, TwiltMarinka, Klein-GitelmanMarisa, Barbar-SmileyFatima, CooperAshley M, EdelheitBarbara, Gillispie-TaylorMiriah, HaysKimberly, MannionMelissa L, PetersonRosemary, FlanaganElaine, SaadNadine, SullivanNancy, SzymanskiAnn Marie, TrachtmanRebecca, TurgunbaevMarat, VeigaKeila, TurnerAmy S, RestonJames T

JIA treatment

This study provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

121.

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.

Author: OnelKaren B, HortonDaniel B, LovellDaniel J, ShenoiSusan, CuelloCarlos A, Angeles-HanSheila T, BeckerMara L, CronRandy Q, FeldmanBrian M, FergusonPolly J, GewanterHarry, GuzmanJaime, KimuraYukiko, LeeTzielan, MurphyKatherine, NigrovicPeter A, OmbrelloMichael J, RabinovichC Egla, TesherMelissa, TwiltMarinka, Klein-GitelmanMarisa, Barbar-SmileyFatima, CooperAshley M, EdelheitBarbara, Gillispie-TaylorMiriah, HaysKimberly, MannionMelissa L, PetersonRosemary, FlanaganElaine, SaadNadine, SullivanNancy, SzymanskiAnn Marie, TrachtmanRebecca, TurgunbaevMarat, VeigaKeila, TurnerAmy S, RestonJames T

Improved quality of life
Shared decision-making

This clinical practice guideline provides recommendations for the management of juvenile idiopathic arthritis (JIA), including nonpharmacologic therapies, medication monitoring, immunizations, and imaging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

122.

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.

Author: OnelKaren B, HortonDaniel B, LovellDaniel J, ShenoiSusan, CuelloCarlos A, Angeles-HanSheila T, BeckerMara L, CronRandy Q, FeldmanBrian M, FergusonPolly J, GewanterHarry, GuzmanJaime, KimuraYukiko, LeeTzielan, MurphyKatherine, NigrovicPeter A, OmbrelloMichael J, RabinovichC Egla, TesherMelissa, TwiltMarinka, Klein-GitelmanMarisa, Barbar-SmileyFatima, CooperAshley M, EdelheitBarbara, Gillispie-TaylorMiriah, HaysKimberly, MannionMelissa L, PetersonRosemary, FlanaganElaine, SaadNadine, SullivanNancy, SzymanskiAnn Marie, TrachtmanRebecca, TurgunbaevMarat, VeigaKeila, TurnerAmy S, RestonJames T

JIA treatment

This study provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

123.

Meta-Analyses on the Effects of Disease-Modifying Antirheumatic Drugs on the Most Relevant Patient-Reported Outcome Domains in Rheumatoid Arthritis.

Author: van den DikkenbergMarijke, Luurssen-MasurelNathalie, KuijperTjallingius Martijn, KokMarc-Redwart, HazesJohanna Maria Wilhelmina, de JongPascal Hendrik Pieter, Lopes-BarretoDeirisa, Weel-KoendersAngelique Elisabeth Adriana Maria

DMARDs for rheumatoid arthritis

This review aims to assess how medications for rheumatoid arthritis (DMARDs) impact patients' quality of life, focusing on areas such as pain, fatigue, limitations in daily activities, overall well-being, and ability to work or manage daily tasks. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

124.

Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.

Author: KrijbolderDoortje I, VerstappenMarloes, van DijkBastiaan T, DakkakYousra J, BurgersLeonie E, BoerAleid C, ParkYune Jung, de Witt-LuthMarianne E, VisserKaren, KokMarc R, MolenaarEsmeralda T H, de JongPascal H P, BöhringerStefan, HuizingaTom W J, AllaartCornelia F, NiemantsverdrietEllis, van der Helm-van MilAnnette H M

RA treatment

Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires long-term treatment. Currently, treatment starts when arthritis is clearly present. This study will investigate whether starting treatment earlier, when people have joint pain but no clear arthritis, can prevent the development of arthritis or reduce the severity of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

125.

Effectiveness of ergonomic interventions on work activity limitations in adults with rheumatoid arthritis: A systematic review.

Author: JonesHeather, YoungMegan, GuytonKyndel, IdemotoEmily, FerraroAlicia, AlHereshRawan

Improved quality of life
Improved work outcomes

Rheumatoid arthritis (RA) is a major cause of disability in the US. Adjusting work environments to make them easier on the body (ergonomic interventions) can be helpful, and when used with medications, may improve work performance and overall quality of life for people with RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

126.

Looking for the best strategy to treat children with new onset juvenile idiopathic arthritis: presentation of the "comparison of STep-up and step-down therapeutic strategies in childhood ARthritiS" (STARS) trial.

Author: BurroneMarco, MazzoniMarta, NaddeiRoberta, PistorioAngela, SpeltaMaddalena, ScalaSilvia, PatroneElisa, GarroneMarco, LombardiMaria, VillaLuca, PascaleGiulia, CavannaRoberto, RupertoNicolino, RavelliAngelo, ConsolaroAlessandro,

Disease remission

This study aimed to explore the potential benefits of initiating aggressive therapy early in the course of juvenile idiopathic arthritis (JIA), taking advantage of a potential 'window of opportunity' to improve long-term outcomes and prevent cumulative joint damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

127.

Prevention of rheumatoid arthritis: A systematic literature review of preventive strategies in at-risk individuals.

Author: FrazzeiGiulia, MustersAnne, de VriesNiek, TasSander W, van VollenhovenRonald F

RA treatment

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and disability. Before RA develops, there's a preclinical stage where people with a genetic predisposition accumulate factors that increase their risk. Treating people at risk before they develop RA could potentially prevent or delay the disease and have a positive impact on their lives and society.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

128.

Points to consider for cost-effective use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases: results from an umbrella review and international Delphi study.

Author: van der TogtCéleste J T, Van den BemtBart, AletahaDaniel, AltenRieke, ChatzidionysiouKaterina, GallowayJames, IsaacJohn, MullemanDenis, VerschuerenP, VultoArnold G, WelsingPaco M J, VerhoefLise, den BroederAlfons A

Cost-effective b/tsDMARD use

A task force of experts in rheumatology, epidemiology, and pharmacology developed evidence-based points to consider for cost-effective use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in the treatment of inflammatory rheumatic diseases. These points to consider, supported by level 1 or 2 evidence, can be used in clinical practice to enhance cost-effectiveness in b/tsDMARD treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

129.

Observation of the therapeutic effect of auricular bean pressing on early knee osteoarthritis pain: A randomized controlled trial.

Author: LinYeyan, WuYongqin, ZhouXuelai, ShenBin, LvCunxian

KOA pain relief
Knee function

Auricular bean-pressing therapy effectively reduced pain, swelling, and stiffness in patients with early KOA, improving knee function and quality of life.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

130.

Estimating Patient-Specific Relative Benefit of Adding Biologics to Conventional Rheumatoid Arthritis Treatment: An Individual Participant Data Meta-Analysis.

Author: LuoYan, ChalkouKonstantina, FunadaSatoshi, SalantiGeorgia, FurukawaToshi A

Rheumatoid arthritis treatment (certolizumab)

An individual participant data meta-analysis of 3790 patients with rheumatoid arthritis (RA) found that adding certolizumab to conventional treatment was associated with a higher probability of reaching low disease activity. However, the benefit was uncertain for patients with low or high baseline expected probability, suggesting the need for further evaluation.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

131.

Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis.

Author: PugliesiAlisson, de OliveiraAmanda Borges, OliveiraAna Beatrice, XavierRicardo, da MotaLicia Maria Henrique, BertoloManoel Barros, Gonzalez-GayMiguel Angel, CiteraGustavo, de CarvalhoLuiz Sergio Fernandes

Improved RA response
Heterogeneity

Abatacept was associated with a higher chance of achieving an ACR70 response than tocilizumab in patients with rheumatoid arthritis (RA) refractory to methotrexate (MTX) or tumor necrosis factor inhibitor (TNFi) therapy.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

132.

Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial.

Author: ØstergaardMikkel, van VollenhovenRonald F, RudinAnna, HetlandMerete Lund, HeibergMarte Schrumpf, NordströmDan C, NurmohamedMichael T, GudbjornssonBjorn, ØrnbjergLykke Midtbøll, BøyesenPernille, LendKristina, Hørslev-PetersenKim, UhligTill, SokkaTuulikki, GrondalGerdur, KrabbeSimon, LindqvistJoakim, GjertssonInger, GlinatsiDaniel, KapetanovicMeliha Crnkic, AgaAnna-Birgitte, FaustiniFrancesca, ParmannePinja, LorenzenTove, GiovanniCagnotto, BackJohan, HendricksOliver, VedderDaisy, RannioTuomas, GrenholmEmma, LjosåMaud Kristine, BrodinEli, LindegaardHanne, SöderberghAnnika, RizkMilad, KastbomAlf, LarssonPer, UhrenholtLine, JustSøren Andreas, StevensDavid J, Bay LaurbjergTrine, BaklandGunnstein, OlsenInge Christoffer, HaavardsholmEspen A, LampaJon,

Improved clinical remission
Reduced radiographic progression

Abatacept and certolizumab pegol were more effective than active conventional therapy in achieving clinical remission in patients with early rheumatoid arthritis.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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