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Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily.

Author: CottonMark F, DerendorfHartmut, InnesSteve, RosenkranzBernd, SySherwin K B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A population pharmacokinetic model suggests that halving the standard pediatric stavudine dose (0.5 mg/kg BID) may maintain antiviral efficacy while significantly reducing mitochondrial toxicity.
Paper Details　
Original Abstract of the Article :
The antiviral efficacy of stavudine depends on the trough concentration of its intracellular metabolite, stavudine-triphosphate (d4T-TP), while the degree of stavudine's mitochondrial toxicity depends on its peak concentration. Rates of mitochondrial toxicity are high when stavudine is used at the c...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910857/

データ提供：米国国立医学図書館（NLM）

Reduced-Dose Stavudine for HIV-Infected Children: A Pharmacokinetic Modeling Approach

The treatment of HIV infection in children presents unique challenges, requiring careful consideration of drug dosage and potential side effects. This study explores the pharmacokinetics of stavudine, a commonly used antiretroviral drug, in HIV-infected children, focusing on the potential benefits of a reduced dose. The authors, like pharmacologists navigating the complex landscape of drug metabolism, aim to optimize treatment strategies for young patients.

Finding the Right Dose: A Pharmacokinetic Model for Pediatric Stavudine

The study presents a population pharmacokinetic model to predict intracellular stavudine triphosphate (d4T-TP) concentrations in pediatric HIV-infected patients receiving a reduced dose of stavudine. The model suggests that halving the standard pediatric dose may provide similar antiviral efficacy with significantly reduced mitochondrial toxicity. It's like finding a delicate balance in the desert of drug dosing, maximizing efficacy while minimizing harmful effects.

Optimizing Treatment for Pediatric HIV Infection

This study highlights the importance of individualized drug dosing in pediatric HIV treatment. The authors emphasize the need for pharmacokinetic modeling to optimize drug therapy, ensuring both antiviral efficacy and safety. It is like using a compass and map to navigate the complex landscape of drug dosing, ensuring that the journey is both effective and safe.

Dr. Camel's Conclusion

This study offers a promising approach to optimizing stavudine therapy for HIV-infected children. By using pharmacokinetic modeling to guide drug dosing, we can potentially achieve better treatment outcomes while minimizing potential side effects. It's a testament to the continuous pursuit of innovation in the vast desert of pediatric HIV research, striving to improve the lives of young patients.

Date :
  1. Date Completed 2014-09-22
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24295968

DOI: Digital Object Identifier

PMC3910857

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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