Paper Details

  1. Home
  2. Paper Details

Attention-deficit hyperactivity disorder (ADHD) as a pyridoxine-dependent condition: urinary diagnostic biomarkers.

Author: DolinaS, MalitskyS, MargalitD, RabinkovA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study analyzed pyridoxal phosphate (PLP)-dependent tryptophan (TRP) degradation in ADHD patients and found that the activity of pyridoxine-dependent enzymes was impaired. Long-term pyridoxine treatment normalized ADHD behavior without causing serious side effects.
Paper Details　
Original Abstract of the Article :
The data obtained in children with different forms of epilepsy allowed us to consider epilepsy as an inborn error of pyridoxine (vitamin B6) metabolism (Dolina et al., 2012). Mutual interconnections between ADHD and epilepsy indicate that such an approach is reasonable for ADHD. To check such an ass...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.mehy.2013.11.018

データ提供：米国国立医学図書館（NLM）

ADHD: A Pyridoxine-Dependent Condition?

We're delving into the exciting world of neurology, specifically exploring the potential link between Attention-Deficit Hyperactivity Disorder (ADHD) and vitamin B6 deficiency. This study employed a thorough analysis of pyridoxal phosphate (PLP)-dependent tryptophan (TRP) degradation pathways in ADHD patients. The researchers meticulously compared the results to those of epileptic children who often have similar metabolic disturbances. Their findings suggest that ADHD could be a pyridoxine-dependent condition, meaning vitamin B6 deficiency may play a significant role in its development.

A Common Biochemical Background for ADHD and Epilepsy?

The study's key finding, similar patterns of TRP degradation in untreated ADHD and epileptic patients, sheds light on a potential common biochemical background for both conditions. This discovery could revolutionize our understanding of these neurological disorders.

Vitamin B6: A Potential Solution for ADHD?

This study offers a glimmer of hope for individuals with ADHD. Long-term pyridoxine treatment may be a promising, pathogenetically based replacement therapy for this complex condition. The researchers observed that multi-year pyridoxine treatment effectively normalized ADHD behaviors without causing any serious side effects.

Dr.Camel's Conclusion

This study, like a shimmering oasis in the vast desert of neurology, provides promising new insights into ADHD. The findings suggest that vitamin B6 deficiency could be a major player in ADHD, opening doors for potential treatment options. While further research is needed, this study offers hope for a future where ADHD is better understood and managed.

Date :
  1. Date Completed 2014-08-04
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24321736

DOI: Digital Object Identifier

10.1016/j.mehy.2013.11.018

Related Literature

Article Analysis
・Side Effects of pyridoxine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.