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Efficiency and side effects of sorafenib therapy for advanced hepatocellular carcinoma: a retrospective study by the anatolian society of medical oncology.

Author: BalakanOzan, BerkVeli, BiliciAhmet, BuyukberberSuleyman, CinkirHavva Yesil, DemirciUmut, ErdoganBulent, GumusMahmut, KaplanMehmet Ali, OflazogluUtku, OksuzogluBerna, OzdemirNuriye, OzkanMetin, OzturkTurkan, TastekinDidem, TonyaliOnder, TurkmenEsma, UnalOlcun Umit, UyeturkUmmugul, YasarNurgul

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Sorafenib, a multi-kinase inhibitor, shows significant improvements in life expectancy and quality of life for patients with inoperable and metastatic hepatocellular carcinoma (HCC). This study evaluated the efficacy and side effects of sorafenib therapy in Turkey.
Paper Details　
Original Abstract of the Article :
Inoperable and metastatic hepatocellular carcinoma (HCC) is associated with a poor prognosis and low chemotherapeutic efficiency. Sorafenib is an oral multi-kinase inhibitor exerting its effects via the RAF/ MEK/ERK pathway, vascular endothelial growth factor receptor (VEGFR) and platelet derived gr...See full text at original site
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引用元：
https://doi.org/10.7314/apjcp.2013.14.12.7367

データ提供：米国国立医学図書館（NLM）

Evaluating Sorafenib Therapy for Advanced Hepatocellular Carcinoma

This research investigates the efficacy and side effects of sorafenib therapy for advanced, inoperable, and metastatic hepatocellular carcinoma (HCC). The study utilized a retrospective analysis of patient data from the Anatolian Society of Medical Oncology in Turkey. The findings suggest that sorafenib therapy can contribute to life expectancy and quality of life for HCC patients, although it is associated with potential side effects.

Sorafenib's Impact on HCC Patient Outcomes

The study found that sorafenib therapy was associated with a significant contribution to life expectancy and quality of life for HCC patients, consistent with previous randomized studies. These findings highlight the potential benefits of sorafenib in managing advanced HCC. However, the study also revealed that sorafenib therapy was associated with certain side effects, which is a common occurrence with cancer treatments.

Understanding the Role of Sorafenib in HCC Treatment

This research underscores the importance of considering both the potential benefits and risks of sorafenib therapy for HCC patients. Healthcare providers should carefully weigh the potential advantages of sorafenib against its potential side effects when making treatment decisions for individual patients. Just as a camel adapts its pace based on the challenges of the desert terrain, healthcare professionals must carefully navigate the complexities of cancer treatment to ensure optimal outcomes for their patients.

Dr.Camel's Conclusion

This study highlights the critical need for ongoing research to develop new and more effective treatments for advanced hepatocellular carcinoma. It reminds us that the fight against cancer is a continuous journey, requiring perseverance and a commitment to improving patient outcomes. Just as a camel endures the hardships of the desert, healthcare professionals must remain dedicated to providing the best possible care for their patients.

Date :
  1. Date Completed 2015-01-06
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

24460304

DOI: Digital Object Identifier

10.7314/apjcp.2013.14.12.7367

Related Literature

Article Analysis
・Side Effects of sorafenib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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