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Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery.

Author: AbuhammadA, RyanA, SimE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Arylamine N-acetyltransferases (NATs) are polymorphic enzymes involved in drug metabolism. This article discusses their role in drug metabolism, substrate specificity, and potential implications for drug development and cancer therapy.
Paper Details　
Original Abstract of the Article :
Arylamine N-acetyltransferases (NATs) are polymorphic drug-metabolizing enzymes, acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides. The slow NAT phenotype increases susceptibility to hydralazine and isoniazid toxicity and to occupational bladder cancer. The two poly...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158862/

データ提供：米国国立医学図書館（NLM）

Unveiling the Secrets of Arylamine N-acetyltransferases: A New Frontier in Drug Discovery

The field of drug metabolism is a complex and fascinating area of study, where enzymes play a crucial role in shaping the fate of drugs within the body. This research focuses on arylamine N-acetyltransferases (NATs), a group of enzymes that are involved in the metabolism of various drugs and carcinogens. The study explores the diverse roles of NATs in drug metabolism, pharmacogenetics, and drug discovery, highlighting their significance in various aspects of medicine. The findings offer valuable insights into the intricate world of enzyme function and its implications for drug development and patient care.

NATs: A Versatile Family of Enzymes

The study emphasizes the critical roles played by NATs in drug metabolism, particularly their involvement in the detoxification of harmful substances. The research also explores the potential of NAT inhibitors as therapeutic agents, specifically in the treatment of tuberculosis. This study sheds light on the versatile nature of NAT enzymes and their potential for targeted therapeutic interventions.

A Guide Through the Labyrinth of Drug Metabolism: The Importance of Understanding NATs

This research underscores the importance of understanding the intricate workings of enzymes like NATs in drug metabolism. By gaining deeper insights into their function and interactions with various drugs, we can develop more effective and safer medications. This study is like a compass guiding us through the labyrinth of drug metabolism, helping us navigate this complex landscape with greater precision and understanding.

Dr. Camel's Conclusion

The research on arylamine N-acetyltransferases provides a valuable glimpse into the intricate world of drug metabolism. The findings highlight the importance of understanding enzyme function and its impact on drug efficacy and safety. It's like uncovering a hidden treasure in the vast desert of drug research, revealing new pathways for developing better treatments and improving patient outcomes.

Date :
  1. Date Completed 2014-12-28
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

24467436

DOI: Digital Object Identifier

PMC4158862

SNS
PICO Info
in preparation
Languages

English

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