Naltrexone extended-release injection: an option for the management of opioid abuse.

Author: PergolizziJoseph V, RaffaRobert B, TaylorRobert

Paper Details 
Original Abstract of the Article :
The United States Food and Drug Administration (FDA) approved naltrexone, a synthetic competitive antagonist at opioid receptors, in oral form in 1984 for use in the management of opioid abuse and addiction. Because naltrexone and its major metabolite, 6-β-naltrexone, are both competitive antagonist...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846318/

データ提供:米国国立医学図書館(NLM)

Naltrexone Extended-Release Injection: A New Hope for Opioid Abuse?

The field of addiction treatment is constantly evolving, with researchers seeking new and effective ways to combat the devastating effects of opioid abuse. This study delves into the potential of naltrexone extended-release injections as a promising tool for managing opioid dependence. The authors explore the mechanisms of action of naltrexone, comparing it to the oral formulation. They highlight the advantages of the extended-release formulation, particularly its ability to improve adherence and retention rates. The authors also acknowledge potential concerns, such as liver damage and the possibility of opioid overdose if patients attempt to override the effects of naltrexone. The focus is on presenting the current knowledge regarding the safety and efficacy of this innovative treatment approach.

Naltrexone Extended-Release Injections: A Monthly Dose for Long-Term Recovery

This research sheds light on the potential benefits of extended-release naltrexone injections, suggesting a promising avenue for improving treatment outcomes for individuals struggling with opioid dependence. The monthly administration of naltrexone injections, as opposed to the daily oral regimen, could significantly enhance medication compliance, a crucial factor in achieving lasting recovery. This approach could potentially lead to higher retention rates and improved overall outcomes for patients.

Balancing the Benefits and Risks of Naltrexone Extended-Release Injections

The study underscores the importance of a careful consideration of the potential risks and benefits associated with extended-release naltrexone injections. While the extended-release formulation offers a potential solution for enhancing medication compliance, the possibility of liver damage at higher doses and the risk of opioid overdose in certain situations warrants close monitoring and careful patient management. The authors advocate for a balanced approach, weighing the benefits against the potential risks and ensuring appropriate patient selection and treatment plans.

Dr. Camel's Conclusion

This research offers a ray of hope for individuals battling opioid dependence. Naltrexone extended-release injections, with their potential for improved compliance and efficacy, could play a significant role in the future of opioid addiction treatment. However, like a desert oasis that needs careful management, the use of this drug requires a balanced and thoughtful approach to ensure its safety and efficacy for each individual.

Date :
  1. Date Completed 2014-06-24
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24474859

DOI: Digital Object Identifier

PMC3846318

SNS
PICO Info
in preparation
Languages

English

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