A trial evaluating gradual- or immediate-switch strategies from risperidone, olanzapine, or aripiprazole to iloperidone in patients with schizophrenia.

Author: AlvaGus, BramsMatthew, CitromeLeslie, GlickIra D, HochfeldMarla, JacksonRichard, KianifardFarid, MattinglyGreg, MengXiangyi, PestreichLinda, WeidenPeter J, WinseckAdam

Paper Details 
Original Abstract of the Article :
In a 12-week randomized open-label trial, adults diagnosed with schizophrenia experiencing inadequate efficacy and/or poor tolerability on risperidone, olanzapine, or aripiprazole were randomized to switch to iloperidone either gradually (ie, down-titration of current therapy over the first 2weeks [...See full text at original site
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引用元:
https://doi.org/10.1016/j.schres.2013.11.042

データ提供:米国国立医学図書館(NLM)

Switching Antipsychotics: Gradual or Immediate? A Detailed Study on Iloperidone

Finding the right medication for [schizophrenia] is a challenging journey for patients. This research compares two strategies for switching patients from one antipsychotic to another: [gradual switching] and [immediate switching]. The study evaluates [the effectiveness and safety of switching to iloperidone] using a [randomized open-label trial] and explores [the impact of different switching strategies] on patient outcomes.

Iloperidone Shows Promise for Switching Antipsychotics

The study found that [switching to iloperidone, regardless of the method, improved patient outcomes]. The researchers observed [similar improvements in overall efficacy and safety/tolerability] between the gradual and immediate switching groups. These findings provide valuable insights into [the optimal approach to switching antipsychotics] for patients with schizophrenia.

Finding the Right Path Through Treatment

The research on iloperidone is like a patient navigating a complex desert of treatment options. It provides clear signposts indicating that [switching to iloperidone] can be a successful route to improve outcomes, regardless of whether the journey is gradual or immediate. This study offers reassurance and valuable guidance for both patients and their clinicians.

Dr.Camel's Conclusion

This research is like finding a reliable camel caravan route in the vast desert of antipsychotic treatment options. Whether you choose to trek slowly or take a direct route, iloperidone appears to be a safe and effective way to reach a destination of improved outcomes for those living with schizophrenia.

Date :
  1. Date Completed 2015-04-22
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

24529610

DOI: Digital Object Identifier

10.1016/j.schres.2013.11.042

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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