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Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial.

Author: , AndersonMaija, CelentanoDavid, ChariyalertsakSuwat, ChenYing Q, CohenMyron S, EronJoseph, EshlemanSusan H, EssexMax, GallantJoel, GambleTheresa, GodboleSheela V, GrinsztejnBeatriz, HakimJames G, HavlirDiane, HoffmanIrving, HosseinipourMina C, KumarasamyNagalingeshwaran, KumwendaJohnstone, MakhemaJoseph, MayerKenneth H, McCauleyMarybeth, MillsLisa A, Nielsen-SainesKarin, OuSan-San, PanchiaRavindre, PilottoJose H S, Piwowar-ManningEstelle, RibaudoHeather J, SanneIan, SwindellsSusan, TahaTaha E, WangLei, de MeloMarineide Gonçalves

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antiretroviral treatment for HIV-1 infection has significantly reduced AIDS-related morbidity and mortality. This study compares the effects of starting antiretroviral treatment early versus later on clinical outcomes. Previous research found that early treatment reduced HIV-1 transmission by 96%, and this study aims to investigate further benefits of early treatment.
Paper Details　
Original Abstract of the Article :
Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related morbidity and mortality and prevents sexual transmission of HIV-1. However, the best time to initiate antiretroviral treatment to reduce progression of HIV-1 infection or non-AIDS clinical events is unknown. We reported p...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/24602844

データ提供：米国国立医学図書館（NLM）

Effects of Early versus Delayed Initiation of Antiretroviral Treatment on Clinical Outcomes of HIV-1 Infection: Results from the Phase 3 HPTN 052 Randomised Controlled Trial

HIV-1 infection, a serious global health concern, has been significantly impacted by the development of antiretroviral therapy (ART). However, determining the optimal time to initiate ART remains an important question. This study explores the effects of early versus delayed initiation of ART on clinical outcomes in patients with HIV-1 infection.

The authors conducted a large-scale, phase 3, randomized controlled trial (HPTN 052) to compare the effects of early and delayed initiation of ART. The study found that early initiation of ART significantly reduced the risk of HIV-1 disease progression, non-AIDS clinical events, and mortality. These findings provide compelling evidence supporting the benefits of early ART initiation for individuals with HIV-1 infection.

Early Antiretroviral Treatment: A Powerful Strategy for Managing HIV-1 Infection

This research provides a strong argument for advocating early ART initiation in HIV-1 infection. The study demonstrates that early treatment can significantly improve clinical outcomes, leading to better long-term health and quality of life for patients. These findings encourage healthcare providers to consider early ART initiation for individuals with HIV-1 infection, potentially leading to a significant reduction in the burden of the disease.

HIV-1 Treatment: The Importance of Early Intervention

This study highlights the critical importance of early intervention in HIV-1 infection. The findings emphasize the potential for early ART initiation to dramatically improve clinical outcomes, ultimately leading to better health and well-being for individuals living with HIV-1. This research encourages continued efforts to expand access to ART and promote early treatment for individuals with HIV-1 infection, potentially contributing to a significant reduction in the global impact of the disease.

Dr. Camel's Conclusion

HIV-1 infection is like a harsh desert environment, but early ART initiation is like a life-giving oasis. This study demonstrates that early treatment can significantly improve clinical outcomes for individuals living with HIV-1, offering hope for a better future. The findings encourage a proactive approach to managing HIV-1 infection, emphasizing the importance of early intervention in combating this challenging disease.

Date :
  1. Date Completed 2014-06-09
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

24602844

DOI: Digital Object Identifier

NIHMS619296

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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